Insulin detemir
The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus
... complications. Insulin therapy often results in weight gain and does not always ensure adequate glycemic ...that insulin detemir is an efficient long‑acting insulin with a weight sparing ...of ...
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Lower risk of hypoglycaemia and greater odds for weight loss with initiation of insulin detemir compared with insulin glargine in Turkish patients with type 2 diabetes mellitus: local results of a multinational observational study
... either insulin detemir or insulin glargine within the previous 3 months could be enrolled in the study at the discretion of the in- ...receiving insulin treatment for more than 3 months were ...
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The role of insulin detemir in overweight type 2 diabetes management
... of insulin therapy in the management of type 2 diabetes requires the use of an effective insulin formulation that is both safe and acceptable to patients and physicians ...long-acting insulin ...
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An update on the treatment of type 1 and type 2 diabetes mellitus: focus on insulin detemir, a long-acting human insulin analog
... and detemir on EEG measures and food intake in 15 healthy men during 2 hyperinsulinemic euglycemic clamps that included an insulin bolus injection (human insulin, detemir) followed by a steady ...
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Insulin detemir for the treatment of obese patients with type 2 diabetes
... with insulin detemir versus other insulins is that it facilitates the actions of central nervous system mechanisms associated with ...satiety. Insulin detemir may be more effective than ...
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Once-Weekly Exenatide Versus Once- or Twice-Daily Insulin Detemir: Randomized, open-label, clinical trial of efficacy and safety in patients with type 2 diabetes treated with metformin alone or in combination with sulfonylureas
... of detemir was not strictly enforced and patients reduced the dosage if hypoglycemia occurred, leading to a mean titrated dose of detemir at end point ...of detemir used in other trials of type 2 ...
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Analog insulin detemir for patients with type 1 and type 2 diabetes: a review
... of insulin detemir is accomplished by attaching a 14-carbon fatty acid chain (myristic acid) to the lysine residue at position B29 such that each monomer bears a myristic acid side ...of insulin ...
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Two-way crossover comparison of insulin glargine and insulin detemir in basal-bolus therapy using continuous glucose monitoring
... of insulin glargine was compared with those of insulin detemir using ...with insulin glargine than with insulin ...that insulin glargine has a greater glucose-lowering effect ...
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Initiation of once daily insulin detemir is not associated with weight gain in patients with type 2 diabetes mellitus: results from an observational study
... lin detemir, independent of changes in concomitant OHA therapy, remain to be elucidated, but various pos- sibilities have been suggested ...with insulin detemir compared with traditional human ...
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Design and rationale of a large, international, prospective cohort study to evaluate the occurrence of malformations and perinatal/neonatal death using insulin detemir in pregnant women with diabetes in comparison with other long acting insulins
... of insulin detemir during pregnancy, and to monitor the health status of resulting infants (exposed in utero) up to 1 year of ...with insulin detemir, compared with other basal insulin ...
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Original Article Comparative research on insulin detemir combined with repaglinide and insulin aspart 30 in treating aged type 2 diabetes mellitus
... the insulin detemir combined with repaglinide in treating elderly T2DM patients that OAD therapy is failure has more advantages, such as good hypoglycemic lipid regulating effect, low blood glucose ...
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Insulin detemir in a twice daily insulin regimen versus a three times daily insulin regimen in the treatment of type 1 diabetes in children: A pilot randomized controlled trial
... usual insulin regimen (intermediate acting insulin and rapid acting analogue at breakfast, rapid acting analogue at dinner and inter- mediate acting insulin at ...acting insulin was ...
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<p>Cost-Effectiveness of Insulin Glargine and Insulin Detemir in the Basal Regimen for Naïve Insulin Patients with Type 2 Diabetes Mellitus (T2DM) in Malaysia</p>
... The initial objective of UKPDS was to determine the effect of intensive glycemia control on the incidence of complication and the study design was similar to the randomized clinical trial. 36 Even though the sample might ...
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From insulin detemir to glargine: Effect on glycemic control and psychological wellbeing in patients with diabetes mellitus type 2 in daily practice
... (basal) insulin-analogues could possibly improve PRO, particularly with regards to quality of life ...daily insulin glargine and once to twice or twice daily insulin detemir have previously ...
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Iowa medicaid 2: lapse of glycemic control on abrupt transition from insulin glargine to insulin detemir in type 2 diabetes mellitus
... from insulin glargine to insulin detemir from 08/06 until 03/07 was ...ceiving insulin glargine were included in the study be- cause the primary aim of the study was to assess com- parative ...
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Tolerability, safety and adherence to treatment with insulin detemir injection in the treatment of type 2 diabetes
... human insulin to form insulin analogs can compromise binding properties, and also the metabolic and mitogenic potencies associated with endogenous human insulin, since this peptide hormone also has ...
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Critical appraisal of the safety and efficacy of insulin detemir in glycemic control and cardiovascular risk management in diabetics
... Abstract: Insulin detemir is an analog of human insulin designed to provide a long duration of basal insulin ...of insulin detemir molecules and in part from reversible albumin ...
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Evaluating the cost-effectiveness of insulin detemir versus neutral protamine Hagedorn insulin in patients with type 1 or type 2 diabetes in the UK using a short-term modeling approach
... PSA yielded similar outcomes to the deterministic base-case analyses with incremental quality-adjusted life expectancy of 0.101 QALYs (standard deviation [SD] 0.038 QALYs) and incremental costs of GBP 59 (SD GBP 45) in ...
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Insulin analogues dosing and costs - comparing real-life daily doses of insulin detemir and insulin glargine in type 2 diabetes patients
... Dose comparisons were strictly performed for the same treatment algorithm (once daily dosing of DET or GLAR) in accordance with the aim of the study (as it otherwise would include off-label use of GLAR). Patients with ...
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Characterisation of insulin analogues therapeutically available to patients
... dosage insulin and its analogues were ...(glargine, detemir, ...dimer, detemir was a multi-hexameric system, degludec was a dodecamer (di-hexamer) and glulisine was present as a ...
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