insulin-like growth factor 2
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer
... The insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) plays essential roles in embryogenesis and ...and growth, invasion, and chemo-resistance, associating with a ...
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The Role of Insulin-Like Growth Factor 2 and Its Receptors in Human Tumors
... insulator that prevents binding of enhancers to pro- moter regions in the IGF-2 gene. Thus, enhancer re- gions distal to H19 gene would have free access to the IGF-2 gene promoter leading to IGF-2 ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... of growth hormone could also contribute to the disappointing activity of this class of ...to insulin resistance secondary to high levels of growth hormone, a compensatory reaction to IGF-1R ...
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Insulin like growth factor type 1 deficiency in a Moroccan patient with de novo inverted duplication 9p24p12 and developmental delay: a case report
... a 2-year-old Moroccan girl with a de novo duplication of 9p24 to ...an insulin-like growth factor type 1 ...an insulin-like growth factor binding protein ...
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<p>Downregulated level of insulin in COPD patients during AE; role beyond glucose control?</p>
... necrosis factor-alpha were the most frequently studied biomarkers. 2 In our previous studies, we found that levels of serum insulin-like growth factor binding protein 7 (IGFBP7) ...
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Combined sprint and resistance training abrogates age differences in somatotropic hormones
... serum growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in re- sponse to a combined sprint ...
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Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies
... phase 2 is needed to develop new therapeutic ...prematurity, growth restriction is in addition to hyperoxia, an established risk-factor for ROP development [10, ...(weight, insulin-like ...
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Human conditions of insulin like growth factor I (IGF I) deficiency
... [56,290]; 2) Angiogenesis, because IGF-I is known to exert signifi- cant pro-angiogenic effects, inducing proliferation of microvascular endothelial cells in culture through HIF-1α and VEGF [291]; 3) Endothelial ...
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A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action
... Although we show that IGFBP-4 concentrations are not altered following osteogenic di ff erentiation of hDPCs, it is well established that the activity of IGFBP-4 in fi broblast and osteoblast cultures can be modified by ...
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Short-Term Growth Hormone Treatment in Girls With Turner Syndrome Decreases Fat Mass and Insulin Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
... for 2 months and stud- ied at the end of each ...GH, insulin-like growth factor I (IGF-I), IGF binding proteins (IGFBPs), insulin, glucose, and lipolytic and gluconeogenic ...
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Ovine placental lactogen and insulin like growth factor I : a study of their biological actions and potential to enhance animal production : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand
... alter growth rate. Although newborn lambs are reported to exhibit adult-like binding of GH to hepatic receptors (Gluckman et ...Chapters 2 and 3) in which GH treatment had a stimulatory effect on ...
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New developments in the treatment of HER2-positive breast cancer
... Figure 2 Mechanisms of resistance to trastuzumab: (1) epitope masking, such that a cell surface molecule (MUC4) hides the epitope to which trastuzumab binds, preventing recognition and binding of human epidermal ...
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Adult growth hormone deficiency treatment with a combination of growth hormone and insulin like growth factor 1 resulting in elevated sustainable insulin like growth factor 1 and insulin like growth factor binding protein 3 plasma levels: a case report
... A 45-year-old Caucasian woman with early ovarian fail- ure of two years duration came to our clinic. She was diagnosed with AGHD with a IGF-1 plasma level of 126 ng/mL. At entrance to our program she was on Human ...
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The Role of Insulin like Growth Factor-1 (IGF-1) in the Diagnosis of Colorectal Carcinoma. A Case Control Study
... pituitary growth hormone exerts its growth effect through an intermediate class of growth promoting peptides named ...termed insulin like growth factor (IGF) IGF-1 and ...
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PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients
... literature [8,14,17]. Similar to others [16,31], we ob- served an association with low tumor grade and negative HER2 status. Although others did not observe a signifi- cant association between PIK3CA mutations and tumor ...
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Utilizing network pharmacology to explore the underlying mechanism of Radix Salviae in diabetic retinopathy
... endothelial growth factor; TCM: Traditional Chinese Medicine; OB: oral bioavailability; DL: drug‑likeness; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; PPI: protein–protein interaction; ...
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Insulin like growth factors and insulin like growth factor binding proteins in mammary gland function
... The insulin-like growth factors (IGF)-I and -II are single- chain polypeptides that share 62% homology in their amino acid ...I insulin-like growth factor receptor ...
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Towards the development of a reliable protocol for mesenchymal stem cell cardiomyogenesis
... (BMP-2/4), insulin-like growth factor (IGF-1) and fibroblast growth factor (FGF- 2) in combination is a potent inducer of MSC ...
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Building Muscle: The Role of Insulin-Like Growth Factor Binding Protein-6 and Insulin-Like Growth Factors in the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle
... The IGF family plays a central role in muscle development, differentiation, growth, and regeneration (14-16, 30, 31). IGFBPs are the carriers for IGFs in the circulation (7), protecting them from degradation (6, ...
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Insulin-like Growth Factor Binding Proteins.pdf
... muscle cells secrete a serine protease for insulin like growth insulin-like growth factor binding proteins 1 and 3 on. factor binding protein-2[r] ...
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