insulin-like growth factor receptors
Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression
... of insulin receptor substrate 1 (31), al- though the functions of these effects during the Ad life cycle are not ...the growth and morphological properties of normal epithelial ...
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Cellular distribution of insulin degrading enzyme gene expression Comparison with insulin and insulin like growth factor receptors
... both insulin and IGFs and has been proposed to play a role in signal termination after binding of these peptides to their ...with insulin receptor (IR) and IGF-I receptor (IGFR) gene expression in serial ...
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G protein coupled and tyrosine kinase receptors: evidence that activation of the insulin like growth factor I receptor is required for thrombin induced mitogenesis of rat aortic smooth muscle cells
... I receptors (and thus recep- tor availability) may play a key role in maintaining an active IGF I–IGF I receptor signaling ...I receptors on VSMC (40, 41) and their mitogenic effects are blocked by anti–IGF ...
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A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action
... IGFBP-4 proteolysis is dependent on the presence of IGF [42] and IGF1 was included in these assays (Methods section and see below). Fig. 2a shows that intact 28 kDa IGFBP-4 was proteolysed following incubation with ...
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Human insulin like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant
... Hybrid receptors were studied in GC rat pituitary cells overexpressing either wild-type 950Tyr (WT) human insulin-like growth factor I (IGF-I) receptors or mutant human IGF-I ...
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The Role of Insulin-Like Growth Factor 2 and Its Receptors in Human Tumors
... suppressed growth of mammary ...secreted insulin-like sub- stance stimulated glucose uptake by rat epididymal adipose cells and competed with radiolabeled in- sulin for binding to these ...of ...
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Insulin like growth factors and insulin like growth factor binding proteins in mammary gland function
... The insulin-like growth factors (IGF)-I and -II are single- chain polypeptides that share 62% homology in their amino acid ...two receptors for IGFs exist, the primary signalling receptor ...
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Building Muscle: The Role of Insulin-Like Growth Factor Binding Protein-6 and Insulin-Like Growth Factors in the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle
... the insulin receptor ...hybrid receptors (HR-A and HR-B) with the IGF- 1R, which bind to both IGFs with variable affinities ...to insulin, it can bind to IR-A ...the growth, differentiation, ...
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Hypoglycemic effect of insulin like growth factor 1 in mice lacking insulin receptors
... I insulin-like growth factor can mimic some of insulin’s effects on fuel metabolism ...of insulin receptor–defi- cient mice generated by targeted inactivation of the insulin ...
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Changes in pain and insulin like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides
... A tendency to correlation was noted between baseline IGF-1 and the decrease of pain in response to exercise. However, this positive tendency disappeared when age was accounted for, and population studies show that IGF-1 ...
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Intrauterine Growth Restriction: A Perspective for Pakistan
... According to M de Onis, IUGR is a major public health problem worldwide, which contributes to closing the intergenerational cycle of poverty, disease and malnutrition 8 , A prevalence of IUGR in access of 20% has been ...
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Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies
... oxide, growth factors, or in- flammatory cells such as leucocytes, monocytes, or macrophages/microglia are implicated in the control of angiogenesis and/or play a detrimental role in the devel- oping vasculature ...
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THE INSULIN-LIKE GROWTH FACTORS.pdf
... lation associates with cellular proteins such as phosphatidylinositol 3' kinase, most likely through src-homology 2 (SH2) domains (20a). The phosphoprotein pp175 is also an endogenous substrate for the IGF-I and ...
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Insulin like growth factor type 1 deficiency in a Moroccan patient with de novo inverted duplication 9p24p12 and developmental delay: a case report
... normal delivery; she was admitted for genetic evaluation because of psychomotor delay and failure to thrive. Her birth weight was 2500 g (3rd centile), length was 46 cm (3rd centile), and head circumference was 32 cm ...
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Combined sprint and resistance training abrogates age differences in somatotropic hormones
... Because GH naturally declines with age, there has been increasing interest in the role of GH as an anti-aging factor, and some evidence suggests GH administration increases fatty acid oxi- dation, protein ...
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Children With Idiopathic Short Stature Are Poor Eaters and Have Decreased Body Mass Index
... delayed growth and pubertal development; how- ever, in a strict sense, the diagnosis cannot be made before the time of puberty, when a delay in sexual maturation becomes ...
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Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood
... In this prospective cohort study in Taiwan, we found that maternal H. pylori infection per se did not promote SGA in neonates. We showed that SGA was most likely caused by other H. pylori -induced pathologies and ...
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Growth Hormone Increases Breast Milk Volumes in Mothers of Preterm Infants
... Maternal milk production and plasma concentrations of insulin-like growth factor-i (IGF-i), insulin-like growth factor binding protein-3 (IGFBP-3), and growth hormone (GH) were determine[r] ...
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Muscle growth and flesh quality of farmed Atlantic halibut (Hippoglossus hippoglossus) in relation to season of harvest
... of growth (Rowlerson et ...1998). Growth of the fast muscle involves the hypertrophy of the embryonic fibres until around 150 degree days (10 mm LS) after which additional myotubes are formed (Galloway et ...
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Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer
... Statistical analyses were performed using Statistical Pack- age for the Social Sciences version 17 software (SPSS Inc., Chicago, IL, USA). Two-samples mean comparison was analyzed by t-test. Multiple-sample mean ...
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