Insulin receptor gene
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance
... the insulin receptor gene from three patients with genetic syndromes associated with extreme insulin ...patients, insulin resistance was caused by decreased insulin binding to ...
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Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene
... the gene encoding the human pituitary specific transcription factor Pit-1/GHF-1 resulted in combined deficiencies of growth hormone and prolactin ...the insulin receptor ...the insulin ...
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Glucocorticoid regulation of insulin receptor gene transcription in IM 9 cultured lymphocytes
... state insulin receptor mRNA levels and over the same range of dexamethasone ...on insulin receptor gene transcription, and demonstrate that the insulin receptor ...
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Insulin Receptor Gene Mutations in Iranian Patients with Type II Diabetes Mellitus
... We searched in the literature for each of the mutations found in the present study; however, no similar mutations have been reported in type II diabetes patients. Therefore, it is possible that these mutations could be ...
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Insulin Resistance in Pregnancy Is Correlated with Decreased Insulin Receptor Gene Expression in Omental Adipose: Insulin Sensitivity and Adipose Tissue Gene Expression in Normal Pregnancy
... of insulin sensitivity to gene expression in omental and subcuta- neous adipose tissue of non-obese, non-diabetic pregnant ...Microarray gene pro- filing was performed on subcutaneous and omental ...
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Relationship between polymorphism of insulin receptor gene, and adiponectin gene with PCOS
... the insulin-signaling pathway, gonadotropin secretion and chronic inflammation have been investigated to ascertain the gene possibly involved in susceptibility to PCOS, but results have been contraversial ...
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Rabson Mendenhall Syndrome caused by a novel missense mutation
... Rabson Mendenhall syndrome (RMS) is a rare auto- somal recessive disorder characterized by severe insulin resistance due to mutations in insulin receptor gene (INSR gene). It is ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... reduced insulin sensitivity. Likewise, the IRS1 gene contains polymorphisms located at codon 972 (BstNI) which has been associated with type 2 diabetes mellitus and insulin ...IRS-1 gene is ...
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Mitochondrial dysfunction in patients with primary congenital insulin resistance
... the insulin receptor gene may confidently be assumed to produce congenital, severe insulin resistance, and co-inheritance of a primary mitochondrial defect in all the unrelated patients ...
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Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle A potential mechanism for insulin resistance in the polycystic ovary syndrome
... the receptor since no insulin receptor gene mutations were identified, immunoprecipitation before autophosphorylation corrected the phosphorylation defect and control insulin receptors ...
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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle
... and insulin resistance in skeletal muscle are two major factors in the pathogenesis of type 2 ...the insulin receptor gene (MIRKO) are normo- glycemic but have increased fat ...examined ...
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Hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of the spontaneously obese diabetic rhesus monkey
... human insulin receptor has two isoforms derived from alternative splicing of exon 11 of the insulin receptor ...binds insulin with twofold lower affinity than the type A (lacking exon ...
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Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects
... in gene and miRNA expression leading to the acquisition and persistence of ...of gene expression to levels equivalent to the negative control in cells stably expressing phospho- incompetent mutants (Figure ...
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Abnormal regulation of ribosomal protein S6 kinase by insulin in skeletal muscle of insulin resistant humans
... for insulin resistance, we investigated the influence of insulin on ribosomal protein S6 kinase activities in skeletal muscle of insulin-sensitive and insulin- resistant nondiabetic Pima ...
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Construction of a polycystic ovarian syndrome (PCOS) pathway based on the interactions of PCOS-related proteins retrieved from bibliomic data
... obesity, insulin resistance, hyperandrogenism, elevated luteinizing hormone (LH) concentrations, increased risk of type 2 diabetes mellitus, cardiovascular events and menstrual irregularities ...[3]. ...
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Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... that insulin, insulin analogs, and glucagon-like peptide-1 receptor (GLP-1R) agonists might contribute to increased risk of some types of ...although insulin receptor, ...
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Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease
... the gene expression via efficient binding to their target mRNAs. Gene polymorphisms either in the miRNA target site or in the miRNAs can disrupt this binding which can contribute to the development of ...
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Leptin and the leptin receptor : Molecular and genetic studies
... leptin receptor iso form ...leptin receptor were present in endometrial cells in ...leptin receptor were identified in endometrial epithelial and stromal cells in culture; the long isoform was only ...
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The insulin receptor and the molecular mechanism of insulin action
... This was further validated by the cDNA cloning, which indicated that the intracellular domain of the a-subunit of the insulin receptor is highly homologous with several other tyrosine pr[r] ...
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RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass
... of insulin was blunted (Figure ...improving insulin receptor ...to insulin, chronic insulin exposure plus OPG-Fc increased Glut-1, Glut-4, and Fabp4 gene expression versus ...
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