Insulin Release
The gastrointestinal stimulus to insulin release: I Secretin
... of insulin release after oral stimuli, and that a rapid sequence of humoral events takes place, gastrin releasing secretin and secretin releasing ...secretin release would be augmented by a local ...
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Insulin release is glucose anomeric specific in the human
... greater insulin release than did ...greater insulin release than the beta-glucose anomer in human subjects at low but not at high doses intravenously and that this response is not apparently ...
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Epigenetic programming of glucose regulated insulin release
... plasma insulin and a poor insulin response after ...restored insulin secretory competence in 3aRCY- -KO β ...immature, insulin- expressing cells derived from pluripotent cells revealed higher ...
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Pulsatile insulin release from mouse islets occurs in the absence of stimulated entry of Ca2+
... insulin release. The reports of cyclic variations of circulating insulin in the fasting state made it important to explore whether insulin release is also pulsatile in the absence of ...
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Calcium release channel RyR2 regulates insulin release and glucose homeostasis
... The release of C-peptide in response to glucose was significantly decreased in CPVT mice compared with WT littermates (Supplemental Figure 3A), whereas plasma glucagon levels (Figure 1M) and gluconeo- genic ...
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Adrenalectomy reduces neuropeptide Y–induced insulin release and NPY receptor expression in the rat ventromedial hypothalamus
... plasma insulin levels compared with vehicle (P < 0.05), and insulin remained elevat- ed for 90 minutes (Figure ...on insulin release to a level that was not significant- ly different from ...
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Cholinergic Modification of Glucose Induced Biphasic Insulin Release in Vitro
... An in vitro system for perifusion of rat pancreatic islets has been utilized to define the effects of cholinergic agents on the dynamics of insulin release. In the absence of glucose the effects of either ...
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The gastrointestinal stimulus to insulin release: II A dual action of secretin
... It has been previously demonstrated that secretin is released very rapidly after oral glucose and postulated that it acts as an early trigger to insulin release. This effect would not explain the magnitude ...
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Interactions of acetylcholine and epinephrine on the dynamics of insulin release in vitro
... of insulin release, an effect dependent upon the concentration of epinephrine and of ...of insulin release (5 X 10(-4) mug/ml) and that needed to overcome inhibition of the second phase (5 X ...
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Multiboronic acid conjugated chitosan scaffolds with glucose selectivity to insulin release
... for insulin release; deionised water was used to investigate the natural diffusion of insulin from the nanoparticles; representative blood fructose concentration (diabetic) was used to investigate ...
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Virus induced alterations in insulin release in hamster islets of Langerhans
... glucose-stimulated insulin release and glucose intolerance of shorter duration ...in insulin release, we examined insulin secretion in response to several test agents in isolated ...
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A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man
... epinephrine, whereas both propranolol and Butoxamine blocked lipolysis, tachycardia, and widened pulse pressure. These findings are consistent with an alpha receptor blocking action for phentolamine and beta receptor ...
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Effects of chronic dexamethasone administration on hyperglycemia and insulin release in goats
... of insulin to glucagon in Dex-treated rats ...glucose, insulin and the insulin to glucagon ratio, which might be explained by an increase in the hepatic glycogen output resulting from the stimu- ...
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Early postprandial Insulin secretion: Its relation to Insulin sensitivity
... phase insulin secre- tion during oral glucose tolerance test [OGTT] in Type 2 Diabetes Mellitus (DM) is attributed to glucose ...of insulin resistance in impaired insulin release secondary to ...
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Pattern of insulin delivery after intravenous glucose injection in man and its relation to plasma glucose disappearance
... Plasma insulin concentrations after pulse intravenous injection of glucose show an early rise, which declines towards the prestimulation level ...measured insulin disappearance from the plasma of 17 healthy ...
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Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta cell function
... in insulin content, as compared to islets cultured at ...higher insulin response to glucose than those of the two other ...of insulin release in the presence of low glucose, and a failure to ...
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Insulin Secretion and Metabolism during the Perinatal Period in the Rat: EVIDENCE FOR A PLACENTAL ROLE IN FETAL HYPERINSULINEMIA
... Pancreatic insulin secretory capacity was estimated by measuring (a) the insulin release of isolated islets incubated in the presence of ...the insulin content of the same islets, and (c) the ...
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THE EFFECT OF QUERCETIN ON BLOOD GLUCOSE LEVELS OF NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC (TYPE I & TYPE II) RATS
... mg/kg intraperitoneally. It shows the anti- hyperglycemic activity of quercetin. From the results mentioned above, we can conclude that quercetin probably shows its effect either by the insulinomimetic activity or ...
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Release of insulin produced by the choroid plexis is regulated by serotonergic signaling
... of insulin production in the brain, we first carried out fluorescent in situ hybridization (FISH) for insulin expression across slices of whole mouse ...of insulin mRNA, but also of the pro- tein ...
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Synthesis and release of proinsulin and insulin by isolated rat islets of Langerhans
... Release of newly synthesized proinsulin and insulin occurred under the following conditions: (a) incubation for greater than 60 min; (b) glucose concentrations above 5.3 mmoles/liter; (c) incubation with 5 ...
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