Insulin Secretion
PATHOPHYSIOLOGY OF INSULIN SECRETION
... exogenous insulin lowers the plasma glucose level, reducing the drive and allowing the residual B cells to recover and to regain partial function ...exogenous insulin is once again instituted, the presence ...
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On the mechanism of impaired insulin secretion in chronic renal failure
... It has been suggested that a sustained rise in resting levels of cytosolic calcium [Ca2+]i of pancreatic islets is responsible for impaired insulin secretion in chronic renal failure (CRF). Evidence for ...
8
Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion
... islet insulin secretion during pregnancy were assessed in this ...Total insulin secretion was measured after 90-min incubations of 10 islets in buffered medium containing ...islet ...
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Insight into Insulin Secretion from Transcriptome and Genetic Analysis of Insulin-Producing Cells of Drosophila
... reach secretion sites, the mechanism of which is largely un- ...for insulin secretion in vivo, we sequenced messenger RNA (mRNA) purified from IPCs and identified IPC-enriched gene ...
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Studies of Immunoreaetive Insulin Secretion in NZO Mice in Vivo
... N Z 0 mice therefore exhibit certain characteristics of insulin secretion which are comparable to those seen in human obese diabetics. Later phase insulin release a[r] ...
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Stimulation of insulin secretion by infusion of free fatty acids
... The results indicate that under certain conditions elevated FFA levels may be a potent stimulus of insulin secretion. This response is modified under other conditions such as during chylomicron removal ...
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A physiologic role for somatostatin 28 as a regulator of insulin secretion
... on insulin secretion of "physiologic" infusions of S-28 and (b) measuring insulin responses during elevated nutrient-stimulated endogenous S-28 ...min. Insulin responses during S-28 ...
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Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin
... endogenous insulin se- ...dogenous insulin secretion were likely to be diagnosed younger and have lower BMI, consistent with a greater proportion having type 1 diabetes, but had similar HbA1c ...
7
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B
... stimulated insulin secretion ...GLP-1–potentiated insulin se- ...potentiated insulin release by z ...baseline insulin release (glucose 1.6 mM), similar to the magnitude of ...
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Dynamics of insulin secretion and the clinical implications for obesity and diabetes
... Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal ...of insulin secretion can be studied at different levels: the single β ...
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A Possible Role for the Adenylcyclase System in Insulin Secretion
... stimulated insulin secretion in vitro; oxytocin and vasopressin, which do not stimulate lipolysis in adipose tissue, were ...of insulin secretion could not be detected when glucose was absent ...
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Inhibition of In Vivo Insulin Secretion by Prostaglandin E1
... Circulating insulin decreased significantly during PGE 1 infusion were significantly less than control ...of insulin secretion was again seen. Inhibition of insulin secretion could not ...
7
Foxa2 regulates multiple pathways of insulin secretion
... of insulin secretion by pancreatic β cells is perturbed in several diseases, including adult-onset (type 2) diabetes and persistent hyperinsulinemic hypoglycemia of infancy ...excessive insulin ...
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The effect of unhealthy β-cells on insulin secretion in pancreatic islets
... for insulin release (Figure ...the insulin secretion is built around a fast central oscillator [10,38,39] consisting of the plasma membrane potential V and the fraction n of open delayed rectifying ...
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Targeting development of incretin producing cells increases insulin secretion
... and insulin responses to an OGTT, and the glucose tolerance in HFD-fed mice improved after DBZ ...early insulin peak was particularly noticeable in HFD-fed mice treated with DBZ (Figure ...of insulin ...
8
Induction of insulin secretion in engineered liver cells by nitric oxide
... stimulates insulin secretion in various non-beta cell lines incubated with the human insulin adenovirus To determine whether the stimulatory effect of L-arginine on insulin secretion is ...
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Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT T15 cells
... of insulin gene expression in the beta cell may also involve Ca2+-signaling pathways and FK506 has been associated with insulin-requiring diabetes mellitus during clinical ...human insulin gene ...
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The role of c-Kit and insulin receptor tyrosine kinases in beta cell function and insulin secretion
... stimulate insulin release. There is little consensus on the role of insulin-stimulated insulin secretion since multiple studies have presented both stimulatory and inhibitory roles (summarized ...
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Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action
... -NMMA–induced insulin resistance is coincident with the on- set of hypertension (14), and thus, one could speculate that in- sulin resistance is etiologically related to hypertension in this ...that insulin ...
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Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non insulin dependent diabetes mellitus
... were insulin resistant and had a delayed insulin and C-peptide response during oral glucose tolerance tests compared with ...first-phase insulin response and a decreased maximal insulin ...
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