insulin signaling
Manipulating insulin signaling to enhance mosquito reproduction
... IIS signaling in the ovary could lead to the secretion of additional 20-hydroxyecdysone, which in turn signals vitellogenesis in the fat body ...increased insulin signaling in the fat body may ...
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Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding
... whole-body insulin sensitivity, suggesting that either IMCL is not asso- ciated with insulin sensitivity, the duration of the study was not sufficient to see an effect, or the type or source of myocellular ...
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Insulin signaling promotes germline proliferation in C elegans
... elegans, insulin/IGF-like receptor (IIR) signaling has been implicated in fertility, but the basis for the fertility defect had not been previously ...IIR signaling is required for robust larval ...
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Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway in Drosophila
... How might Tsl function in the PG to regulate systemic insulin signaling? Because Tsl is a secreted protein, this could be explained if Tsl is secreted from the PG into the hemolymph. We therefore asked if ...
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Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
... impair insulin signaling by increasing serine phosphorylation of IRS-1 (and possibly other IRS proteins) (127, 128, ...inhibits insulin receptor tyrosine kinase activity, which leads to impaired ...
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Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
... resistance, and fatty liver disease. Here we have dissected mechanisms underlying this association using mice fed either chow or HFD with or without fructose- or glucose-supplemented water. In chow-fed mice, there was no ...
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Exercise modulates postreceptor insulin signaling and glucose transport in muscle specific insulin receptor knockout mice
... by insulin stimulation in vitro (8–13, 15, ...Alternatively, insulin may bind to recep- tors other than the IR, leading to activation of alterna- tive signaling molecules that promote glucose trans- ...
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Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice
... of insulin lowers blood glucose levels and inhibits endogenous glucose production (GP) within ...minutes. Insulin exerts its potent effects on hepatic glucose fluxes via direct and indirect mechanisms ...
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Leptin regulation of Hsp60 impacts hypothalamic insulin signaling
... and insulin resistance (8, 9), but it has not been shown that mitochondrial dysfunction in the brain causes insulin ...induces insulin resistance in the hypothalamus, indicating that mitochondrial ...
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Turning down insulin signaling
... an insulin receptor ...obese, insulin-resistant humans and ...the insulin resist- ance in animals, a finding that has yet to be replicated in diabetic humans (20, ...of insulin ...
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EFFECT OF TROXERUTIN ON CARDIAC INSULIN SIGNALING IN HIGH FAT, HIGH FRUCTOSE DIET - INDUCED INSULIN RESISTANT MICE
... impaired insulin signaling through reduced IRS-I tyrosine ...cardiac insulin signaling by augmenting insulin-stimulated IRS–PI3K–Akt pathway in the heart of HFFD-fed ...of ...
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Seven-Up Is a Novel Regulator of Insulin Signaling
... body insulin signaling, affecting immune gene expression and lipid ...promote signaling downstream of the dInR especially in the face of chronic HS ...and insulin signaling conditions, ...
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Increased CD36 protein as a response to defective insulin signaling in macrophages
... in insulin signaling in mouse macrophages increase oxLDL bind- ing and CD36 protein ...high-dose insulin on insulin receptor β-subunit (far left) and CD36 protein expression (middle panels), ...
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Myotubularin-related protein 7 inhibits insulin signaling in colorectal cancer
... of insulin signaling in human CRC ...RTK signaling in KRAS-WT and KRAS-mutated cells, and there was no correlation between MTMR7 loss and KRAS-mutations in CRC ...
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Insulin signaling modulates border cell movement in Drosophila oogenesis
... oogenesis, Insulin signaling (InS) allows the transition from the pre-vitellogenic to vitellogenic phase and modulates mitotic-to-endocycle transition of follicle cells (Jouandin et ...Drosophila ...
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Impact of acute heat treatment on autophagy and insulin signaling in C2C12 myotubes
... Heat treatment can provide many benefits to skeletal muscle, such as reduced oxidative stress, improved insulin signaling, and increased mitochondrial biogenesis [11, 12]. Heating of C2C12 skeletal muscle ...
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Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
... and insulin resistance, and/or in the protection from β cell failure ...of insulin action (10–13) and that these complex interactions play a pivotal role in common forms of insulin resistance ...
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MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling
... Our findings demonstrate that the regulatory circuit defined in the cell studies is operative in vivo. Following administration of an HFD to mice, a structural homolog of SBI-477, SBI-993, reduced TAG levels in muscle ...
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Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
... BD, Insulin signaling: inositol phosphates get into the Akt, ...IRS, insulin receptor substrate; PI3-K, class IA phosphatidylinositol 3-kinase; PIP2, phosphatidylinositol (4,5)-bisphosphate; PIP3, ...
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Insulin Signaling in Microdomains of the Plasma Membrane
... on signaling. For example, the rapid termination of insulin signaling by phosphatases or retrophosphorylation pathways could play a key role in delineating the downstream effects of the hormone, ...
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