insulin signalling
Growth control through regulation of insulin signalling by nutrition activated steroid hormone in Drosophila
... as signalling pathways, with external cues, such as nutritional status, is paramount for an orderly progression of development and ...involves insulin and steroid signalling, but the underlying ...
13
Macrophage-derived factors impair insulin signalling pathway in human adipose cells: role of IL-1β
... the insulin signalling molecules in human ...in insulin-stimulated phosphorylation of IRS-1(Ser612) in all groups (Figure ...on insulin-stimulated phosphorylation of ...of insulin on ...
293
Methionine restriction improves renal insulin signalling in aged kidneys.
... For insulin signalling experiments, male mice only were ...or insulin (10 mU/g body weight) was administered after 5 hour fast, and mice sacrificed by cervical dislocation after 10 ...
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The effects of intravenous, glucose versus saline on ovarian follicles and their levels of some mediators of insulin signalling
... The effect of glucose on ovarian follicles appears to be dependent on the stage of development of the follicles. In the population of small follicles the effect of glucose was to stimulate their growth a conclusion that ...
14
miR-449a regulates insulin signalling by targeting the Notch ligand, Jag1 in skeletal muscle cells
... Notch signalling pathway in cellular metabolic pathways and correlation to obesity, insulin resistance and ...and insulin resistant mouse models [23, 33] and inhibition of this pathway in the liver ...
10
High-fat diet feeding alters metabolic response to fasting/non fasting conditions. Effect on caveolin expression and insulin signalling
... blood insulin increment caused by food intake did not sub- stantially modify the situation (Table 1), and the drop in IR or IRS-2 expression was also less pronounced (Figure ...altered insulin response that ...
10
Enhancement of insulin signalling in adipose tissue by malarial extracts
... the insulin signalling pathways to look ...which insulin stimulates ACC (see section ...by insulin is known to be inhibited by wortmannin, suggesting that this enzyme is downstream of ...of ...
254
Short-and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue
... investigating insulin signalling cascade protein phosphorylation, and in order to activate the insulin signalling cascade, media was spiked with human insulin ...
7
Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway
... Our previous researches have reported that mulberry leaf is able to down-regulate the expression of TLR2 and TLR4 in pancreas of KKAy [10], that the main compo- nents of water extracts of mulberry leaf (WEM) have been ...
12
Insulin signalling in mushroom body neurons regulates feeding behaviour in Drosophila larvae
... of insulin signalling disrupts the development and/or maintenance of mushroom body ...which insulin signalling was inhibited by targeted expression of PI3K(DN) and FOXO using the same GAL4 ...
7
A temporal switch in the insulin signalling pathway that regulates hepatic IGF binding protein 1 gene expression
... which insulin-signalling pathways will regulate it (Hall & Granner 1999, Patel et ...while insulin represses, PEPCK, G6Pase and IGF-binding protein-1 (IGFBP1) gene transcription, with the effects ...
11
Disruption of insulin signalling affects the neuroendocrine stress reaction in Drosophila females
... The insulin/insulin-like growth factor signalling pathway has also recently been found to be involved in the regulation of various processes, including stress ...and insulin signalling ...
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Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans
... We [28,55,56] and others [57] found repeatedly that impairment of IIS signalling resulted in much higher standing levels of ATP than normal. This finding is most surprising as it seems to violate common ...
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Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans
... Lowering insulin-IGF-1-like signalling (IIS) activates FOXO transcription factors (TF) to extend life span across species. To study the dynamics of FOXO chromatin occupancy under this condition in C. ...
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Evidence of insulin dependent signalling mechanisms produced by Citrus sinensis (L ) Osbeck fruit peel in an insulin resistant diabetic animal model
... the insulin signalling pathway (Sharma et ...stimulate insulin signalling with possible applicability to T2DM, resulting in a growing number of patents (Singh and Mahajan, 2013; Salimifar et ...
48
An In Silico Comparative and Pathway Analysis of Targeted Genes of Diabetic Retinopathy: A Prognostic Approach towards Diabetic Retinopathy
... the Insulin signalling pathway, MAPK signalling, TGF-beta signalling and neurotrophin signalling pathway respectively were selected as genes linked to ...
11
Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs daily breakfast consumption in lean and obese adults
... and insulin-stimulated Akt activation and tissue glucose uptake rates were also ...and insulin signalling genes (ACADM and IRS2) were up-regulated with FAST versus BFAST (ACADM: ...and ...
14
Investigation of Pancreatic -Cell Insulin Receptor Regulation of Investigation of Pancreatic -Cell Insulin Receptor Regulation of -Cell Growth, Function, and Survival Via a Temporal Conditional Knockout
... glucose-stimulated insulin secretion. To elucidate the role of insulin signalling in mature β-cells, several β-cell-specific Ir knockout studies using the rat insulin promoter have been ...
119
Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes
... and insulin concentrations were almost missing, drawing attention to the biological importance of genetically determined path- ways that contribute to the development of ...in insulin action and lipid ...
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Reconstruction of the insulin like signalling pathway of Haemonchus contortus
... which combine to precisely regulate the insulin signalling pathway response (i.e., downstream gene expression) to the complex set of environmental cues experienced by this free-living nematode [70]. It is ...
10