Integrase strand transfer inhibitors
Effect of HIV-1 Integrase Resistance Mutations When Introduced into SIVmac239 on Susceptibility to Integrase Strand Transfer Inhibitors
... to integrase strand transfer inhibitors (INSTIs) have been ...various integrase (IN) mutations that had been selected with HIV under drug pressure with raltegravir (RAL), elvitegravir ...
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Mutations Located outside the Integrase Gene Can Confer Resistance to HIV 1 Integrase Strand Transfer Inhibitors
... the integrase strand transfer inhibitors raltegravir and elvite- gravir is often due to well-identified mutations in the integrase ...the integrase gene but highlighted the ...
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Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239
... (HIV) integrase (IN) strand transfer inhibitors (INSTIs) and that the same IN drug resistance mutations result in similar pheno- types in both ...characteristics strand transfer, ...
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Prevalence of resistance to integrase strand transfer inhibitors (INSTIs) among untreated HIV 1 infected patients in Morocco
... to INIs. Despite the limited size of the study population, these results are in good agreement with the current situation of HIV in Morocco as reported in the national report on AIDS [1]. The high prevalence of subtype B ...
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Altered Viral Fitness and Drug Susceptibility in HIV-1 Carrying Mutations That Confer Resistance to Nonnucleoside Reverse Transcriptase and Integrase Strand Transfer Inhibitors
... Nonnucleoside reverse transcriptase (RT) inhibitors (NNRTI) and integrase (IN) strand transfer inhibitors (INSTI) are key com- ponents of antiretroviral regimens. To explore potential ...
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Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
... Integrase inhibitors are emerging anti-human immunodeficiency virus (HIV) drugs, and multiple retrovi- ruses and transposable elements were evaluated here for susceptibilities to raltegravir (RAL) and ...
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The Combination of the R263K and T66I Resistance Substitutions in HIV-1 Integrase Is Incompatible with High-Level Viral Replication and the Development of High-Level Drug Resistance
... of integrase strand transfer inhibitors (INSTIs), which are the most potent antiretroviral drugs (ARVs) to date and include ralte- gravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) ...
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Clinical effectiveness of dolutegravir in the treatment of HIV/AIDS
... that integrase inhibitors (INTs, also known as integrase strand transfer inhibitors or INSTIs) represent a relatively new class of antiretroviral drugs to treat HIV-1 ...
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Switch rates, time to switch, and switch patterns of antiretroviral therapy in people living with human immunodeficiency virus in Japan, in a hospital claim database
... transcriptase inhibitors (NRTIs) as backbone plus a third drug (the anchor drug) from the other classes, including non-nucleoside reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), ...
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Viral fitness cost prevents HIV 1 from evading dolutegravir drug pressure
... that integrase strand transfer inhibitors can be used to treat HIV-1 ...first-generation integrase inhibitors are susceptible to the emergence of resistance mutations that impair ...
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In vitro activity of dolutegravir against wild type and integrase inhibitor resistant HIV 2
... that integrase strand transfer inhibitors (INSTI) might be particularly useful for HIV-2 ...potent inhibitors of HIV-2 replication in culture [14-18], and case reports and small case ...
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HIV drug resistance against strand transfer integrase inhibitors
... Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from ...
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Lack of integrase inhibitors associated resistance mutations among HIV 1C isolates
... countries integrase strand transfer inhibitors have been shown to lead to virological sup- pression in both treatment naïve patient as well as treat- ment-experienced individuals with ...
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Inhibitors of the integrase–transportin SR2 interaction block HIV nuclear import
... IN inhibitors have been approved for clinical use (raltegravir, elvitegravir and dolutegravir), all belonging to a class of catalytic site inhibitors known as integrase strand transfer ...
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Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitroand provide a rationale to redesign antiretroviral treatment for feline AIDS
... Amino acid sequence alignment of the lentiviral integrase catalytic core domain (IN CCD). Amino acid sequences were aligned with BioEdit and alignments manually edited to eliminate gaps. FIV-Fca, FIV-Oma, and ...
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Resistance Mutations in Human Immunodeficiency Virus Type 1 Integrase Selected with Elvitegravir Confer Reduced Susceptibility to a Wide Range of Integrase Inhibitors
... that strand transfer inhibitors bind close to the flexible loop and that inhibitor binding impedes loop mobility and hence catalytic activity ...for strand transfer inhibitor binding ...
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Emerging role of integrase inhibitors in the management of treatment-experienced patients with HIV infection
... Abstract: Integrase is an essential HIV-1-specifi c enzyme that is an active target for antiretroviral drug ...inhibits strand transfer, one of the three steps of HIV integration into the host DNA, ...
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Allosteric Integrase Inhibitors Reveal a Role for Integrase During HIV-1 Maturation
... IN inhibitors (239). INSTIs inhibit vDNA strand transfer activity by binding to the intasome nucleoprotein complex at the enzyme active site and displacing the terminal deoxyadenylate residue of ...
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Raltegravir, elvitegravir, and metoogravir: the birth of "me too" HIV 1 integrase inhibitors
... as strand transfer ...the strand transfer step calls for a tetrameric IN ...IN inhibitors have been avidly sought over the last ten years as a supplement to HAART and a novel angle of ...
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Patterns of resistance development with integrase inhibitors in HIV
... only integrase (IN) inhibitor approved for use in HIV therapy, has recently been ...IN strand transfer ...IN strand transfer inhibitors ...
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