Integrin-linked kinase
Integrin linked kinase: both Jekyll and Hyde in rhabdomyosarcoma
... that integrin-linked kinase (ILK) acts as a tumor suppressor in ERMS and as a proto-oncogene in ARMS, and that the opposing functions of this enzyme are dependent on the JNK1 signaling pathway (see ...
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Integrin linked kinase regulates p38 MAPK dependent cell cycle arrest in ureteric bud development
... The integrin-linked kinase (ILK), pinch and parvin ternary complex connects the cytoplasmic tails of 1 integrins to the actin ...protein kinase (MAPK) in vivo and in ...the kinase ...
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JNK1 determines the oncogenic or tumor suppressive activity of the integrin linked kinase in human rhabdomyosarcoma
... Akt-regulated transcription factor forkhead in rhabdomyosarco- ma (FKHR; also referred to as forkhead box O1A). These transloca- tions occur in frame, yielding chimeric transcription factors that are poor prognostic ...
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Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis
... Background: Neural crest defects lead to congenital heart disease involving outflow tract malformation. Integrin-linked-kinase (ILK) plays important roles in multiple cellular processes and ...
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Role for integrin linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
... that integrin-linked kinase (ILK) plays an important role in medi- ating tubular EMT induced by ...dominant-negative, kinase-dead form of ILK largely abrogated TGF-β1–initiated tubular cell ...
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Interaction of Infectious Spleen and Kidney Necrosis Virus ORF119L with PINCH Leads to Dominant-Negative Inhibition of Integrin-Linked Kinase and Cardiovascular Defects in Zebrafish
... Infectious spleen and kidney necrosis virus (ISKNV) is the type species of the Megalocytivirus genus, Iridoviridae family, causing a severe systemic disease with high mortality in mandarin fish (Siniperca chuatsi) in ...
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Cooperative signaling between Wnt1 and integrin linked kinase induces accelerated breast tumor development
... pathways. Integrin-linked kinase (ILK)-mediated signaling is one such ...of integrin receptors and is involved in oncogenesis through the induction of antiapoptotic pathways and cell-cycle ...
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Involvement of integrin-linked kinase in capillary/tube-like network formation of human vascular endothelial cells
... The integrin-linked kinase (ILK) is a serine/threonine protein kinase that was initially identified as the integrin β1-tail-binding protein ...protein kinase catalytic domains ...
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El-Aouni, Chiraz (2006): In Vivo modulation of integrin linked kinase using transgenic mice. Dissertation, LMU München: Fakultät für Biologie
... α3β1 integrin appear unable to assemble mature foot processes, and form instead, flattened cytoplasmic projections from the podocyte cell body to the GBM (Kreidberg et ...this integrin are essential for ...
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Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization
... Integrin linked kinase (ILK) is a ubiquitously expressed scaffold protein that functions as a central component and mediator of cell- extracellular matrix (ECM) interactions (Novak et ...β1 ...
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Original Article Echistatin prevents posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway
... pathways. Integrin linked kinase (ILK) is a serine-threonine kinase and localized at the cell-matrix interface ...lular integrin signals to intracellular signaling ...multiple ...
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Grashoff, Carsten (2007): The role of integrin-linked kinase in vivo and in vitro. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... these integrin-binding proteins is Integrin-linked kinase (ILK) which directly interacts with β1 and β3 ...the integrin adhesion sites and stimulates downstream signalling cascades ...
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Renal Integrin-Linked Kinase Depletion Induces Kidney cGMP-Axis Upregulation: Consequences on Basal and Acutely Damaged Renal Function
... pathologies. Integrin-linked kinase (ILK), a major scaffold protein between the extracellular matrix and intracellular signaling pathways, may modulate the expression and functionality of the ...
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A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial- mesenchymal transition in cancer cells
... and integrin-linked kinase (ILK) that might underlie the ability of cancer cells to maintain high levels of HIF-1α expression and to promote EMT under hypoxic ...
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Radovanac, Korana (2012): Regulation of integrin-linked kinase (ILK) stability. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... signals. Integrin-linked kinase (ILK) is a central constituent of 1 and 3 integrin ...and kinase-like domain, and it forms an obligatory trimeric protein complex with two other focal ...
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Lange, Anika (2010): Genetic analysis of the catalytic activity of Integrin-linked kinase (ILK) in vivo. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... is integrin-linked kinase (ILK), which is recruited to β1 and β3 integrin-mediated adhesion ...and kinase domain and has been shown to directly bind the cytoplasmic parts of these ...
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Unschuld, Paul Gerson (2003): Expressionsanalyse der Integrin Linked Kinase (ILK) bei Schädigung der glomerulären Filtrationsbarriere. Dissertation, LMU München: Medizinische Fakultät
... Signaltransduktionsmolekül Integrin-linked Kinase (ILK), das an Zell-Matrix Kontakten be- teiligt ist ...dieser Kinase an der Regulation von Prozessen auf zellulärer Ebene im ...
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Mechanical signals control SOX 9, VEGF, and c Mycexpression and cell proliferation during inflammation via integrin linked kinase, B Raf, and ERK1/2 dependent signaling in articular chondrocytes
... receptor kinase 1/2; FBS: fetal bovine serum; FLAG: polypeptide protein sequence DYKDDDDK; GDP: guanosine diphosphate; GST: glutathione-S-transferase; GTP: guanosine triphosphate; HRP: horseradish peroxidase; ...
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Modulation of integrin-linked kinase (ILK) expression in human oesophageal squamous cell carcinoma cell lines by the EGF and TGFβ1 growth factors
... While the cellular expression of ILK in HOSCCs is compa- rable to that of other cell types, particularly noteworthy is that ILK expression in HOSCCs appears to be dependent on the receptor recycling of both the EGF and ...
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Calycosin 7 O β D glucoside promotes oxidative stress induced cytoskeleton reorganization through integrin linked kinase signaling pathway in vascular endothelial cells
... serine/threonine kinase Akt/protein kinase B are involved in the signaling cascade to mediate cell migration ...mon kinase PI3K, the two pathways adjust and regulate mutually and demonstrate ...
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