interferon-dependent antiviral genes
Expression of interferon induced antiviral genes is delayed in a STAT1 knockout mouse model of Crimean Congo hemorrhagic fever
... many interferon-induced genes associated with the antiviral re- sponse, but that this response is delayed compared to in- fection of WT ...is dependent on STAT2, since mice lacking both STAT1 ...
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Innate STAT1-Dependent Genomic Response of Neurons to the Antiviral Cytokine Alpha Interferon
... as antiviral proteins, IFNs- ␣ /  are now known to be pleiotropic and plurifunctional molecules with antiproliferative and im- mune-regulatory properties (32, 41), which has led to their widespread therapeutic ...
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Interferon Regulatory Factor 3 Is Necessary for Induction of Antiviral Genes during Human Cytomegalovirus Infection
... Our demonstration that IRF3 is essential for IFN-indepen- dent ISG induction by HCMV in HFs implies that the lack of IRF3 activation or binding observed by others may have had a technical basis, since ...
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Interferon-stimulated genes—essential antiviral effectors implicated in resistance to Theiler’s virus-induced demyelinating disease
... 1001 genes in the spinal ...critical genes of the type I IFN pathway employing conventional statistical methods as described [41, 43, ...Most genes were significantly up-regulated by TMEV infection ...
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A Short Hairpin RNA Screen of Interferon Stimulated Genes Identifies a Novel Negative Regulator of the Cellular Antiviral Response
... fold, P ⬍ 0.001), and this effect was not observed in DKO MEFs (Fig. 6C). Consistent with this, we observed increased ISG (Ifi44, Irf1, and Rsad2) expression in Ascc3-silenced WT but not Irf3 ⫺/⫺ ⫻ Irf7 ⫺/⫺ DKO MEFs ...
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Membrane Perturbation Elicits an IRF3-Dependent, Interferon-Independent Antiviral Response
... 84 genes within four major functional groups (IFNs, IFN receptors, IFN regulatory factors, and ...ISGs). Genes whose expression was upregulated more than a factor of 2 relative to that of the LF2000 control ...
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Antiviral Activity of Salmonid Gamma Interferon against Infectious Pancreatic Necrosis Virus and Salmonid Alphavirus and Its Dependency on Type I Interferon
... the antiviral activity and gene induction properties of interferon gamma (IFN- ␥ ) compared to type I IFN (IFNa1) in Atlantic ...potent antiviral activity against salmonid alphavirus 3 (SAV3) ...
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Identification of Alpha Interferon-Induced Genes Associated with Antiviral Activity in Daudi Cells and Characterization of IFIT3 as a Novel Antiviral Gene
... HSH2D was not previously reported as being upregulated by type I IFN. It is a protein that was found to protect the WEHI- 231 B-cell line from undergoing apoptosis in response to B-cell antigen receptor complex (BCR) ...
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hsp70 and a Novel Axis of Type I Interferon-Dependent Antiviral Immunity in the Measles Virus-Infected Brain
... of interferon-stimulated genes has an additive inhibitory effect on viral replication, such that the individual fold changes underestimate the cumulative level of host protection ...IFN-stimulated ...
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Topoisomerase II Inhibitors Induce DNA Damage Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion
... I interferon (IFN) responses at multiple levels ...of antiviral genes that can be expressed as a direct result of RLR signaling and independently of IFN ...
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Connexin Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses
... in antiviral responses to many DNA ...of interferon genes (STING) in infected ...amplifying antiviral re- sponses, significantly protecting uninfected epithelial cells against viral ...
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Gamma Interferon-Induced Interferon Regulatory Factor 1-Dependent Antiviral Response Inhibits Vaccinia Virus Replication in Mouse but Not Human Fibroblasts
... IFN-induced genes contain both ISRE and GAS consensus elements in their ...the antiviral potency of IFN- ␥ is reduced drastically but incompletely in IRF-1-deficient cells ...
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Topoisomerase 1 Inhibition Promotes Cyclic GMP AMP Synthase Dependent Antiviral Responses
... of antiviral genes in these ...I interferon (IFN) by SV40T MEFs while having only a modest impact on cell proliferation ...the antiviral protein viperin (encoded by Rsad2) after 24 h ...
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Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway
... ABSTRACT Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which poses a serious threat to the global pig industry. Interferons (IFNs) and IFN-stimulated genes (ISGs) play a ...
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Salmonella Suppresses the TRIF Dependent Type I Interferon Response in Macrophages
... I interferon (IFN) production, inflammasome signaling, and signaling of reti- noic acid-inducible gene I (RIG-I)-like helicase receptors (RLRs) ...(alpha interferon [IFN-␣] subtypes, IFN-  , and IFN- ) ...
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Interferon Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency
... for genes of interest were then normalized to those of US28-R129A cells and then normalized to either the relative amounts of actin or STAT1 as described in the figure ...
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“Self” and “Nonself” Manipulation of Interferon Defense during Persistent Infection: Bovine Viral Diarrhea Virus Resists Alpha/Beta Interferon without Blocking Antiviral Activity against Unrelated Viruses Replicating in Its Host Cells
... an antiviral state similar to that achieved in BVDV-uninfected ...the antiviral activity of IFN remained intact in ncp BVDV-infected cells although these cells were refractory to IFN induction in response ...
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Statistical and methodological concerns about the beneficial effect of neuraminidase inhibitors on mortality
... NAI antiviral use and mortality (median NOS score 6; range ...NAI antiviral treatment, none reported results significantly against NAI antiviral treatment and 28 did not find significant associations ...
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RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity
... the interferon-stimulated gene (ISG) promoter, whereas the wild-type (WT) control cells were not ...RIG-I dependent, we generated RIG-I knockout (RIG-I KO) U937-DC-SIGN cells using clustered regularly ...
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Interferon Induced Protein 44 Interacts with Cellular FK506 Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication
... IFN- ␣ treatment and IAV infection induces the expression of IFI44. In a previous transcriptomic analysis, we found that IFI44 was induced in IAV-infected cells (25). IFI44 has been previously described as an ISG (16, ...
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