interferon gene stimulated 15
Interferon-stimulated gene 15 in hepatitis B-related liver diseases
... of Interferon-stimulated gene 15 (ISG15) polymorphisms, ISG15 serum levels and expression with HBV-related liver ...the gene were screened for polymorphisms in 766 HBV-infected patients ...
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Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits the Antiviral Function of Interferon-Stimulated Gene 15
... I interferon (alpha/beta interferon [IFN- ␣ /  ]) stimulates the expression of interferon-stimulated gene 15 (ISG15), which encodes a ubiquitin-like protein, ...of ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
... vIRF1 expression decreases total cellular ISG15 conjugation to proteins. We demonstrated that vIRF1 associates with the ISG15 E3 ligase HERC5; however, the functional significance of this interaction remained unclear. To ...
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Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway
... on gene expression associated with their anti-cancer activity, DNA microarray analyses were performed in OCI-AML2, a typical acute myelogenous leukemia cell ...
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Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant Hepatitis
... or UbcH8), and an E3 ligase (Herc5, estrogen-responsive finger protein [EFP], or HHARI) (11). Over 160 proteins have been identified as targets of ISG15, including proteins involved in pro- cesses such as protein ...
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Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages
... plasm stimulated second-phase ISG expression via the RNA sensor RIGI or the DNA sensor cGAS (22), and possibly IFI16 (23), we knocked down MAVS (the RIGI adaptor) and STING (the cGAS/IFI16 adaptor) 3 days prior to ...
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Cytomegalovirus InducesInterferon-Stimulated Gene Expression and Is Attenuated by Interferon in the Developing Brain
... As CMV is a particularly damaging virus for the developing brain, we next asked whether less-mature embryonic brain cells show any sign of protection from mCMV infection after IFN treatment. Here we used cells from ...
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Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3
... least 15 h of infection; (ii) it did not react with purified PIV3 virions (data not shown); and (iii) it did not react with un- infected cell extracts or extracts made at early stages of infection ...
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The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses
... mortality following IAV infection (19–21). However, some stud- ies have questioned the significance of this truncated IFITM3 al- lele in the susceptibility to IAV and other viral infections (22, 23). The mechanisms by ...
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Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
... ISG20 has specific antibunyaviral activity. Many divergent viruses are classed as bunyaviruses (1, 2). To further investigate the antiviral spectra of the selected ISGs against bunyaviruses, we screened the ability of ...
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Characterization of the Elements and Proteins Responsible for Interferon-Stimulated Gene Induction by Human Cytomegalovirus
... It is important to identify the VRS-binding proteins, because they are candidate proteins responsible for the induction of ISGs after HCMV-infection. The results from this study sug- gest that it is unlikely that the ...
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Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species
... the interferon type I (IFN-I) response has been shown to rely on posttranslational modification by ubiquitin (Ub) and Ub-like interferon-stimulated gene product 15 (ISG15) to stabilize, ...
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Targeting tumor-associated macrophages to combat pancreatic cancer
... Ang-2, angiopoietin-2; CSC, cancer stem cells; EMT, epithelial-mesenchymal transition; FGF, fibroblast growth factor; ISG-15, interferon-stimulated gene 15; MDSC, myeloid-derived suppres[r] ...
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Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo
... 100-fold) following IFN stimulation (4, 7, 19, 20). It is ex- pressed in a variety of cell types at low levels and induced within 6 h of stimulation with IFN- ␣ /  , and to a lesser degree by IFN- ␥ (26). ISG15 has two ...
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Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells
... The ability of RSV to influence the expression of cell surface receptors may provide an important clue to the cellular biology of viral infection. Through this mechanism, a virally infected cell may have a cellular ...
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DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture
... DDX60L acts independently from DDX60 and restricts HCV RNA replication in Huh-7 cells. DDX60L is a member of the large family of DExD/H box helicases, but no distinct function has been assigned to it so far. The sequence ...
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Type I interferonopathies in pediatric rheumatology
... IRF: interferon regulatory factors; ISG15: interferon-stimulated gene 15; JAK: Janus kinase; JASL: Japanese autoinflammatory syndrome with lipodystrophy; JMP: joint contractures, muscle ...
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25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection
... Similar to results with enveloped viruses, 25HC-mediated restriction of reovirus requires pretreatment of cells for at least 2 h prior to virus adsorption (12) (Fig. 5). This suggests that 25HC does not exert its effects ...
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The Epstein-Barr Virus SM Protein Induces STAT1 and Interferon-Stimulated Gene Expression
... RNA analysis. RNA was isolated with RNAzol B (Teltest, Friendswood, Tex.), and Northern blotting was performed as previously described (51, 52). To isolate nuclear and cytoplasmic RNA fractions, cells were first lysed in ...
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Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems
... In our experimental system, ex vivo stimulation for 4 h of whole blood from healthy donors with rhIFNα was sufficient to induce relatively high levels of expres- sion of all six ISGs tested. The magnitude of relative ...
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