interferon-production
A study on the control of interferon production in lymphoblastoid cells
... on interferon production after induction of HFF cells but had no effect on the WI-26 ...deoxycytidine, interferon titres were not increased in the WI-26 ...on interferon production in ...
223
Inverse relationship between constitutive gamma interferon production and human T-cell lymphoma/leukemia virus expression in cultured T lymphocytes.
... DISCUSSION This study is the first to show an inverse relationship between HTLV and constitutive -y-immune interferon production simultaneously assayed in cultured mature leukemic T-cell[r] ...
7
Type 1 Interferon Induction of Natural Killer Cell Gamma Interferon Production for Defense during Lymphocytic Choriomeningitis Virus Infection
... gamma interferon (IFN- ␥ ) in part because they basally express high levels of the signal transducer and activator of transcription 4 ...The production of type 1 IFNs, both IFN-␣ and IFN-, was shown to be ...
10
The regulation of type I interferon production by paramyxoviruses
... the production of PAMPs, (ii) inhib- iting specifi c cellular components in the type I IFN induc- tion cascade (with mda-5 being a near universal target for all members of the Paramyxovirinae subfamily), and (iii) ...
10
Early Production of Type I Interferon during West Nile Virus Infection: Role for Lymphoid Tissues in IRF3-Independent Interferon Production
... the production of high levels of IFN. IFN production was dependent on the replicative capacity of VLPs, since mice inoculated with UV-inactivated VLPs did not produce ...
9
Immune specific gamma interferon production correlates with lymphocyte blastogenesis
... Gamma interferon IFN--y production, measured by a new commercially available radioimmunoassay, and lymphocyte blastogenesis were investigated in human peripheral lymphocyte cultures from[r] ...
5
Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells
... Activation of the TLR7/9-dependent signaling pathway induces production of IFN- ␣ , which in turn activates transcription of the IRF7 gene, one of the IFN-stimulated genes, via the JAK-STAT pathway. This ...
15
Interferon Production and Inhibition of Host Synthesis in Cells Infected with Vesicular Stomatitis Virus
... Influence of multiplicity of infection on production of interferon in chick embryo cell cultures infected with S2 VS V or L1 VS V Multiplicity of infection 100 10 1 0.1 0.01 Interferon t[r] ...
9
Glucose concentration affects recombinant interferon a-2b production in Escherichia coli using thermo-induction system
... the production of interferon α-2b in both shake flask and in ...protein production and acetate ...biomass production and enhances acetate accumulation in ...maximal interferon ...
5
Priming: a Nonantiviral Function of Interferon
... Interferon production in normal and interferon-treated human embryonic lung cells and LLC-MK2 rhesus monkey kidney cells infected with MM virus, mengovirus, or poliovirus type II Interfe[r] ...
10
Interferon and Host Resistance to Rauscher Virus-induced Leukemia
... These data demonstrate an association between interferon production by the host and the observed relative resistance of the CD-1 strain of adult mice to the subsequent malignant transfor[r] ...
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Comparison of Type I Interferon Expression in Adult and Neonatal Mice during Respiratory Viral Infection
... I interferon expression in 2- day neonatal and six-to-eight-weeks adult mice infected by Sendai virus (SeV), a single- stranded RNA virus of the family ...I interferon mRNA is present in higher levels in ...
10
Production of human lymphoblastoid interferon by Namalva cells
... This paper describes the optimal growth and induction conditions of Namalva cultures and the kinetics of interferon production in cultures with cell densities of 1 x 106 to 10 x 106 cell[r] ...
8
Inducible Expression of Human Gamma Interferon
... proteins production antagonism, is one of the basic drawback in recombinant proteins ...like interferon which we intended to clone and express, inhibit host cells’ ...IFN-γ production during growing ...
6
Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon Inducing RNAs
... Negative-strand RNAs of alphaviruses lack a 5= cap structure and exist as double- stranded RNA (dsRNA) duplexes (called replicative forms) with positive-strand RNAs (25). These properties make them PAMP RNAs that are ...
15
STAT4 Is Required for Antibacterial Defense but Enhances Mortality during Polymicrobial Sepsis
... yielding production of gamma interferon (IFN- ␥), development of the T helper type 1 response, and increased natural killer cell cytotoxicity (25, ...
5
Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice
... protein production (11, ...the production of IFN given that it was serially passaged in CPT-Tert cells (sheep cells that do not to produce IFN upon viral ...IFN production by SBV maps mainly to the ...
11
Original Article The synergetic effects of interferon-γ and lipopolysaccharide on the phenotype, proliferation, and cytokine production of mouse bone marrow mesenchymal stem cells
... STAT1 and NF-κB pathways are critical for cyto- kine production. Furthermore, p-STAT1, STAT1, p-p65, and p65 were detected by Western blot. As shown in Figure 5, IFN-γ induces the phos- phorylation of STAT1, but ...
7
Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... an interferon response, STATs are ini- tially phosphorylated and IFNα signaling is initiated and re- solved quickly, but during chronic inflammation STATs lose their phosphorylation status even in the presence of ...
10
Human Immunodeficiency Virus Type 1 gp120 and Other Activation Stimuli Are Highly Effective in Triggering Alpha Interferon and CC Chemokine Production in Circulating Plasmacytoid but Not Myeloid Dendritic Cells
... It is widely recognized that the expression of IFN- ␣ /  genes is a transient response (regulated at the transcriptional level) of most cell types to viruses or other IFN inducers (15). The nature of the IFN produced ...
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