Interferon Regulatory Factor
Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as well ...
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Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300
... the interferon regulatory factor (IRF) ...the interferon-mediated transcriptional activation of the interferon-stimulated gene 15 (ISG 15) promoter, and the role of vIRF-1 in viral ...
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<p>Transcription factor E2F1 positively regulates interferon regulatory factor 5 expression in non-small cell lung cancer</p>
... IRF5, Interferon regulatory factor 5; E2F1, E2F transcrip- tion factor 1; NSCLC, Non-small cell lung cancer; LC, lung cancer; IRF, interferon regulatory factors; HCV, Hepatitis C ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is ...an interferon-stimulated response element in the TRAIL ...
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Differential Modification of Interferon Regulatory Factor 3 following Virus Particle Entry
... particular, interferon regulatory factor 3 (IRF3) has been shown to be essential for the induction of an antiviral ...robust interferon-stimulated gene (ISG) and antiviral state induction and ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... The rotavirus nonstructural protein NSP1 is the least conserved protein in the rotavirus genome, and its function in the replication cycle is not known. We employed NSP1 as bait in the yeast two-hybrid interaction trap ...
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Interferon Regulatory Factor 7 Is Associated with Epstein-Barr Virus-Transformed Central Nervous System Lymphoma and Has Oncogenic Properties
... Interferon regulatory factor 7 (IRF-7) is implicated in the regulation of Epstein-Barr virus (EBV) latency. EBV transforms primary B cells, and the major EBV oncoprotein, latent membrane protein 1 ...
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Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
... transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus-induced apoptosis following activation via retinoic acid inducible gene I and interferon promoter- ...
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Interferon Regulatory Factor 1 Restricts Gammaherpesvirus Replication in Primary Immune Cells
... Interferon regulatory factor 1 (IRF-1) is a transcription factor that regulates innate and adaptive immune responses and func- tions as a tumor ...
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The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Associates with Interferon Regulatory Factor 7 and Consequently Inhibits Beta Interferon Promoter Activity
... 8 NOTES The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 bICP0 Associates with Interferon Regulatory Factor 7 and Consequently Inhibits Beta Interferon Promoter Activity䌤 Kazi[r] ...
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Arenavirus Nucleoprotein Targets Interferon Regulatory Factor-Activating Kinase IKKε
... Arenaviruses perturb innate antiviral defense by blocking induction of type I interferon (IFN) production. Accordingly, the are- navirus nucleoprotein (NP) was shown to block activation and nuclear translocation ...
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Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia
... the interferon regulatory factor family, acts as an essential transcription factor for differentiation and mat- uration of BM-derived MPs in the myeloid lineage as well as for B cell ...
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HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
... 1 interferon response to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject of conflicting ...
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Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer
... Interferon regulatory factor 3 (IRF3) is a transcription factor involved in the activation of type I alpha/beta interferon (IFN- ␣ /  ) in response to viral ...of interferon ...
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Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection
... pathology. Interferon regulatory factor 1 (IRF-1) is a tumor suppressor that is also involved in the regulation of innate and adaptive im- mune ...I interferon (IFN) and IRF-1 cooperate to ...
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Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts
... with interferon regulatory factor 3 (IRF-3) and that regions in the C-terminal domain of NSP1 were important for mediating this interaction ...
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Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures
... negative regulatory factors with the gene regulatory region ...Positive regulatory domain III (PRDIII) contains an interferon regulatory factor (IRF)-bind- ing element that can ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... Virus infection of mammalian cells prompts the innate im- mune system to mount a first line of defense. Infected cells synthesize and secrete alpha/beta interferons (IFN- ␣ /  ), which cause neighboring cells to express ...
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Original Article Regulatory effect of interferon regulatory factor-1 on lymphatic enhancing factor 1
... Abstract: Interferon regulatory factor (IRF)-1 is one important transcriptional factor and exerts critical roles in anti-vi- rus and ...enhancing factor (LEF)-1 is widely expressed in ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... I interferon (IFN) response requires the coordinated activation of the latent transcription factors NF- B, interferon regulatory factor 3 (IRF-3), and ATF-2, which in turn activate ...
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