Interferon regulatory factor-1 (IRF-1)
Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection
... pathology. Interferon regulatory factor 1 (IRF-1) is a tumor suppressor that is also involved in the regulation of innate and adaptive im- mune ...I interferon (IFN) and ...
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Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene ( IRF1 )
... activated interferon regulatory factor 1 gene ( IRF1 ) and IRF1 transcription are altered by 5 ’ -deoxy-5 ’ -methyl-thioadenosine (MTA) ...with interferon (IFN)g for 30 ...transcription ...
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Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... general starvation and other cellular stresses [8]. By inhibiting the tumor vasculature, bevacizumab, and other antiangiogenic agents may cause nutrient deprivation and oxygen stress in the tumor microenvironment, both ...
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Interferon Regulatory Factor 1 Restricts Gammaherpesvirus Replication in Primary Immune Cells
... in IRF-1-deficient and -profi- cient MHV68-infected primary ...macrophages. IRF-1 can induce expression of IFN-, a member of an extensive family of cytokines that engage a unique type I IFN ...
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Original Article Regulatory effect of interferon regulatory factor-1 on lymphatic enhancing factor 1
... ence. IRF-1 siRNA or negative control sequenc- es were mixed with liposome in 200 μl serum- free medium for 15-min room temperature ...with IRF-1 siRNA or controlled dilutions for 30-min room ...
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Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300
... like IRF-2, behaves as an ...cellular IRF, since it binds to oligonucleotide corresponding to the NF-B ...the IRF family have been shown to play an essential role in the regulated expression of IFN ...
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Suppression of Growth by All-trans Retinoic Acid Requires Prolonged Induction of Interferon Regulatory Factor 1 in Cervical Squamous Carcinoma (SiHa) Cells
... Induction of IRF-1 mRNA and the consequent growth in- hibition in cervical squamous carcinoma cells by ATRA have been demonstrated (7). Clinically, retinoids reversed or sup- pressed low-grade or moderate- ...
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Modulation of Mitochondrial Antiviral Signaling by Human Herpesvirus 8 Interferon Regulatory Factor 1
... with 1 g/ml of recombinant GFP or GFP-fused vIRF-1 expanded PD (aa 1 to 153)-GFP proteins and immunoblotted with anti-GFP ...calculating 1 ⫺ (B max ⫺ B/B max ⫺ B min ), where B is absorbance ...
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Absence of Interferon Regulatory Factor 1 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice
... Although a strong positive correlation of IRF1 with oxidized low-density lipoprotein (ox-LDL) in mammalian atherosclerotic lesions has been suggested previously [12], little information is available concerning the ...
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Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
... Interferon regulatory factor 1 (IRF-1), IRF-3, and IRF-7 have been tested as genetic adjuvants for influenza virus hemagglutinin (HA) and nucleoprotein vaccine ...
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Interferon-Regulated Pathways That Control Hepatitis B Virus Replication in Transgenic Mice
... the interferon (IFN)-inducible genes, those for the IFN regulatory factor 1 (IRF-1), RNase L, and double- stranded RNA-activated protein kinase (PKR) systems are some of the best ...
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Human Herpesvirus 8 Encodes an Interferon Regulatory Factor (IRF) Homolog That Represses IRF-1-Mediated Transcription
... an IRF-1 binding site, but ISGF-3g requires additional flank- ing base pairs to bind ...(gamma interferon-activated factor) (30) that bind the gamma-activated sequence ...to IRF binding ...
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Chimeric oncogenic interferon regulatory factor 2 (IRF 2): Degradation products are biologically active
... that IRF-2 is oncogenic in nature. IRF-2 causes cancer when abnormally over expressed or ...that IRF-2 gene is point mutated lead to inactivation of this gene product ...that IRF-2 exerts its ...
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Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication
... in IRF-3 ⫺/⫺ ⫻ IRF-7 ⫺/⫺ macrophages, we observed IFN-␣4 and IFN-  mRNA induction in IRF-3 ⫺/⫺ ⫻ IRF-7 ⫺/⫺ dendritic cells, especially at later time ...examined, IRF-3 ⫺/⫺ ⫻ ...
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Interferon Regulatory Factor 7 Is Associated with Epstein-Barr Virus-Transformed Central Nervous System Lymphoma and Has Oncogenic Properties
... of IRF-7 are associated with EBV immortalization of ...of IRF-7 is induced during cell ...of IRF-7 in primary and recently EBV-immortalized B ...Fig. 1, a low level of IRF-7 was ...
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Differential Regulation of Interferon Regulatory Factor (IRF)-7 and IRF-9 Gene Expression in the Central Nervous System during Viral Infection
... each IRF with unique functions. For example, IRF-2 has an inhibitory domain that represses the transcriptional activation of other IRFs such as ...IRF-1. IRF-5 is localized primarily to ...
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Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
... transcription factor that plays a role in innate and adaptive immune responses through its ability to regulate the pro- duction of cytokines, receptors necessary for immune recogni- tion, and proteins ...
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Type I interferonopathies in pediatric rheumatology
... IRF: interferon regulatory factors; ISG15: interferon-stimulated gene 15; JAK: Janus kinase; JASL: Japanese autoinflammatory syndrome with lipodystrophy; JMP: joint contractures, muscle ...
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Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3
... KCl, 1 mM EDTA, 1 mM dithio- threitol, ...7.5), 1 mM EDTA, 50 mM NaCl, 2 mM dithiothreitol, 5% glycerol, ...After 1 h at 100 V, the gel was transferred to nylon (Pierce) ...
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Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells
... IFIT3: Interferon induced protein with tetratricopeptide repeats 3; IFN: Interferon; IL1B: Interleukin 1 beta; IL6: Interleukin 6; IRF3: Interferon regulatory factor 3; ISRE: ...
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