Interferon regulatorY FACTOR-3
Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts
... with interferon regulatory factor 3 (IRF-3) and that regions in the C-terminal domain of NSP1 were important for mediating this interaction ...
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Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprout- ing formation and ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is ...an interferon-stimulated response element in the TRAIL ...
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Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer
... ylation at site I may also be important for IRF3 activation (41). We thus generated IRF3-5E/E, in which all five Ser/Thr residues in site II were mutated to Glu (S394E, S396E, S400E, T402E, and S403E) with an additional ...
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Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication
... Human noroviruses (HuNoV) are the major cause of epidemic, nonbacterial gastroenteritis in the world. The short course of HuNoV-induced symptoms has implicated innate immunity in control of norovirus (NoV) infection. ...
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... Cell culture, transfection, and luciferase assays. rtTA-Neo and rtTA–IRF-3 5D Jurkat cells (16) were grown in RPMI 1640 medium containing 10% heat- inactivated calf serum, glutamine, antibiotics, 2.5 g of ...
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HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
... 1 interferon response to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject of conflicting ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... added interferon (IFN), a cytokine which is normally synthesized by cells as a reaction to virus ...transcription factor interferon regulatory factor 3 (IRF-3), which is ...
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Differential Modification of Interferon Regulatory Factor 3 following Virus Particle Entry
... two-step model of IRF3 activation. First, Sarkar et al. observed that following poly(I:C)-mediated phosphorylation, dimeriza- tion, and nuclear translocation of IRF3, a second posttransla- tional modification on IRF3 via ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... I interferon (IFN) response requires the coordinated activation of the latent transcription factors NF- B, interferon regulatory factor 3 (IRF-3), and ATF-2, which in turn ...
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Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
... transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus-induced apoptosis following activation via retinoic acid inducible gene I and interferon ...
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Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
... FIG. 2. Effect on delNS1 virus-induced nuclear accumulation of hIRF-3 in HEC-1b cells by transient transfection of influenza virus NS1 proteins. (A) Coverslips coated with HEC-1b cells were transfected with a ...
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Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer
... (20–22). Interferon regulatory factor 3 (IRF-3) acts as a direct transducer of virus-mediated signaling, and together with IRF-7 controls transcriptional activation of alpha/beta IFN ...
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A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection
... I interferon (IFN) signaling ...potentiate interferon regulatory factor 3 (IRF3) phosphorylation and translocation to the nucleus, the in- duction of IFN-responsive genes, and the ...
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Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway
... translation factor EF-1 ␦ were found to be phosphorylated by BGLF4 at Cdk1 target sites (2, 38, 39, 72, ...cessivity factor BMRF1 at the viral DNA replication compart- ment in virus-replicating cells and ...
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Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
... A second class of cytosolic DNA sensors is represented by the absent in melanoma 2 protein (AIM2). Several laboratories iden- tified Aim2 as a DNA sensor that anchors formation of an AIM2- dependent inflammasome complex ...
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Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection
... of interferon regulatory factor 3 (IRF3), a key transcription factor of the MyD88-independent type I interferon (IFN) production ...
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LGP2 Downregulates Interferon Production during Infection with Seasonal Human Influenza A Viruses That Activate Interferon Regulatory Factor 3
... the interferon regulatory factor 3 (IRF3) and NF-B transcription factors and the activation of interferon (IFN) transcription (6, 11, 16, ...
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Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein
... The V protein of Sendai virus (SeV) suppresses innate immunity, resulting in enhancement of viral growth in mouse lungs and viral pathogenicity. The innate immunity restricted by the V protein is induced through ...
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Interferon Regulatory Factor 3 Is Necessary for Induction of Antiviral Genes during Human Cytomegalovirus Infection
... Viral infection activates interferon regulatory factor 3 (IRF3), a cofactor for the induction of interferon- stimulated genes (ISGs). The role of IRF3 in the activation of ISGs by human ...
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