Interferon regulatory factor 3
HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
... 1 interferon response to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject of conflicting ...
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Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection
... of interferon regulatory factor 3 (IRF3), a key transcription factor of the MyD88-independent type I interferon (IFN) production ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is ...an interferon-stimulated response element in the TRAIL ...
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Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... of interferon (IFN)-stimulated genes ...activate interferon-regulatory factor 3 (IRF3), as well as nuclear factor B (NF- B), which transactivate a subset of ISGs, ...
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Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprout- ing formation and ...
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Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts
... with interferon regulatory factor 3 (IRF-3) and that regions in the C-terminal domain of NSP1 were important for mediating this interaction ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... Virus infection of mammalian cells prompts the innate im- mune system to mount a first line of defense. Infected cells synthesize and secrete alpha/beta interferons (IFN- ␣ /  ), which cause neighboring cells to express ...
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Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
... transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus-induced apoptosis following activation via retinoic acid inducible gene I and interferon ...
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LGP2 Downregulates Interferon Production during Infection with Seasonal Human Influenza A Viruses That Activate Interferon Regulatory Factor 3
... the interferon regulatory factor 3 (IRF3) and NF-B transcription factors and the activation of interferon (IFN) transcription (6, 11, 16, ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... I interferon (IFN) response requires the coordinated activation of the latent transcription factors NF- B, interferon regulatory factor 3 (IRF-3), and ATF-2, which in turn ...
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Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
... Expression plasmids. pCAGGS-NS1(SAM) and pCAGGS-NS1-R38AK41A (SAM) contain the open reading frame of NS1 from wild-type influenza A (PR8) virus in an expression vector containing a chicken -actin promotor (pCAGGS) (26). ...
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Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication
... transcription factor(s) remain unknown; a signif- icant decrease in IFN- ␣ 4 and IFN-  mRNA induction during MNV infection was not observed in macrophages lacking IRF-1 compared to wild-type controls ...
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Differential Modification of Interferon Regulatory Factor 3 following Virus Particle Entry
... by regulatory sequences in their promoters and requires transcrip- tion factors such as IFN regulatory factor 3 (IRF3), NF- B, and AP-1 ...
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Identification of the Rabies Virus Alpha/Beta Interferon Antagonist: Phosphoprotein P Interferes with Phosphorylation of Interferon Regulatory Factor 3
... alpha/beta interferon (IFN)-competent cells, sug- gesting the existence of viral mechanisms preventing IFN gene ...IFN regulatory factor 3 ...
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Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
... A second class of cytosolic DNA sensors is represented by the absent in melanoma 2 protein (AIM2). Several laboratories iden- tified Aim2 as a DNA sensor that anchors formation of an AIM2- dependent inflammasome complex ...
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... ISG15. In comparison with other microarray studies with her- pes simplex virus (HSV)-, HCMV-, and human papillomavirus type 16 (HPV16)-infected cells, a striking overlap in the profile of activated genes was observed, ...
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Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer
... T he hallmark of the innate immune response against viruses is the activation of type I alpha/beta interferon (IFN- ␣ /  ) sig- naling in immune cells (1, 2). IFN- ␣ /  synthesis is triggered by several of the ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... Deletion mutant ⌬326 is missing the N-terminal 326 amino acids. This mutant was constructed by PCR amplification with the negative-sense primer described above and with the posi- tive-sense primer ...
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HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3
... HIV-1 WITO Vpu (or an empty vector as control) and con- structs containing the firefly and Gaussia luciferases (in a 5:1 ratio) under the control of the IFN- and pTAL promoters, respectively. We used the WITO vpu for ...
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Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures
... IRF-3 overexpression can induce IFN-  in the absence of viral infection. IRF-3 overexpression induced IFN- in the absence of viral infection in both L929 cells and primary car- diac myocyte cultures (Fig. ...
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