Interferon regulatory factor 3 (IRF-3)
Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... added interferon (IFN), a cytokine which is normally synthesized by cells as a reaction to virus ...transcription factor interferon regulatory factor 3 (IRF-3), ...
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Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
... transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus-induced apoptosis following activation via retinoic acid inducible gene I and ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is ...that IRF-3 is involved in the transcriptional ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... I interferon (IFN) response requires the coordinated activation of the latent transcription factors NF- B, interferon regulatory factor 3 (IRF-3), and ATF-2, which in ...
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Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... of interferon (IFN)-stimulated genes ...activate interferon-regulatory factor 3 (IRF3), as well as nuclear factor B (NF- B), which transactivate a subset of ISGs, ...
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HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
... 1 interferon response to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject of conflicting ...
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Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprout- ing formation and ...
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Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection
... of interferon regulatory factor 3 (IRF3), a key transcription factor of the MyD88-independent type I interferon (IFN) production ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... The NSP1 zinc finger is important but not sufficient to mediate binding to IRF-3. NSP1 shows considerable diver- gence in amino acid sequence among different rotavirus strains (23). The N-terminal 230 amino ...
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HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3
... to IRF-3 and NF-B, and this served as an internal control for transfection ...the IRF-3 expression levels remained unchanged in the presence of WITO Vpu ...an IRF-3-independent ...
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Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
... FIG. 2. Effect on delNS1 virus-induced nuclear accumulation of hIRF-3 in HEC-1b cells by transient transfection of influenza virus NS1 proteins. (A) Coverslips coated with HEC-1b cells were transfected with a ...
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Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures
... negative IRF-3) contain the human EF-1␣ promoter for constitutive expression (30, 51) and were generously provided by Takashi Fujita (Kyoto University, Kyoto, ...removing IRF-3 from ...
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Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication
... factors IRF-3 and IRF-7 work in concert to initiate unique and overlapping antiviral responses to restrict MNV replication in ...vivo. IRF-3 and IRF-7 restrict MNV replication in ...
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Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis
... 4 Interferon regulatory factor 3 supports Th17 cell differentiation and ...naive interferon regulatory factor – knockout (KO, irf3 −/− ) and wild-type (WT) mice were ...
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Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein
... The SeV V protein is essential for efficient virus growth in mouse lungs and for viral pathogenicity. The V protein counteracts in- nate immunity, and the immunity is exerted through activation of IRF3 (23). In the ...
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Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer
... proteins were expressed with an N-terminal 6 ⫻ His tag. The nucleotide sequence of the gene was optimized for expression in Escherichia coli. The individual domains of IRF3 were designed on the basis of the sequence ...
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Differential Modification of Interferon Regulatory Factor 3 following Virus Particle Entry
... following two-dimensional gel electrophoresis, a phosphospe- cific IRF3 antibody was used. Extracts from fibroblasts infected with NDV and the related paramyxovirus SeV were compared since we routinely observe enhanced ...
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Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
... A second class of cytosolic DNA sensors is represented by the absent in melanoma 2 protein (AIM2). Several laboratories iden- tified Aim2 as a DNA sensor that anchors formation of an AIM2- dependent inflammasome complex ...
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Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
... Interferon regulatory factor 1 (IRF-1), IRF-3, and IRF-7 have been tested as genetic adjuvants for influenza virus hemagglutinin (HA) and nucleoprotein vaccine ...with ...
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Differential Regulation of Interferon Regulatory Factor (IRF)-7 and IRF-9 Gene Expression in the Central Nervous System during Viral Infection
... of IRF-2 (33), IRF-3 (5), and IRF-9 (14) genes by a wide variety of cell types, while IRF-5 (10) and IRF-7 (6) genes are expressed predominantly by he- matopoietic ...the ...
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