Interferon regulatory factor 3 (IRF3)
Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... of interferon (IFN)-stimulated genes ...activate interferon-regulatory factor 3 (IRF3), as well as nuclear factor B (NF- B), which transactivate a subset of ISGs, ...
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Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection
... of interferon regulatory factor 3 (IRF3), a key transcription factor of the MyD88-independent type I interferon (IFN) production ...that IRF3-deficient mice ...
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HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
... 1 interferon response to viral infection by degradation of the interferon regulatory factor 3 (IRF3) has been subject of conflicting ...of IRF3 in primary CD4 ⴙ T cells ...
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Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprout- ing formation and ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is ...an interferon-stimulated response element in the TRAIL ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... Virus infection of mammalian cells prompts the innate im- mune system to mount a first line of defense. Infected cells synthesize and secrete alpha/beta interferons (IFN- ␣ /  ), which cause neighboring cells to express ...
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Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts
... with interferon regulatory factor 3 (IRF-3) and that regions in the C-terminal domain of NSP1 were important for mediating this interaction ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... I interferon (IFN) response requires the coordinated activation of the latent transcription factors NF- B, interferon regulatory factor 3 (IRF-3), and ATF-2, which in turn ...
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Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
... transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus-induced apoptosis following activation via retinoic acid inducible gene I and interferon ...
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Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein
... native IRF3 was observed (Fig. 5). IRF3 accumulated in the nucleus of some uninfected cells ...of IRF3 was probably a low transfection efficiency of ...of IRF3 was not observed, and some cells ...
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Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer
... alpha/beta interferon (IFN- ␣ /  ) sig- naling in immune cells (1, ...the interferon regulatory factors (IRFs) (3–5). IRF3 is expressed constitutively in various cell ...cells, ...
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Differential Modification of Interferon Regulatory Factor 3 following Virus Particle Entry
... cific IRF3 antibody was ...enhanced IRF3 phosphorylation following SeV infection of fibroblasts relative to NDV infection, despite induction of similar antiviral responses ...of IRF3 were readily ...
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... (Table 3), whereas other microar- ray studies demonstrated that the ISGs listed in Table 3 were upregulated in response to IFN-␣ and/or IFN- (8, 9, ...
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Varicella-Zoster Virus Immediate-Early Protein 62 Blocks Interferon Regulatory Factor 3 (IRF3) Phosphorylation at Key Serine Residues: a Novel Mechanism of IRF3 Inhibition among Herpesviruses
... human IRF3-5D and green fluorescent protein (GFP)-IRF3, TBK1, and HA-TRAF3 were kindly provided by Adolfo Garcia-Sastre (Mount Sinai School of Medicine), David Baltimore (California Institute of ...
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Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
... an IRF3/IFN- response following DNA transfection or HSV1 infection ...the IRF3/IFN pathway in the RAW ...to IRF3 activation, can also form with ASC to generate a RIG-I-dependent inflam- masome ...
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Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures
... IRF-3 overexpression can induce IFN-  in the absence of viral infection. IRF-3 overexpression induced IFN- in the absence of viral infection in both L929 cells and primary car- diac myocyte cultures (Fig. ...
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Structural and functional characterization of MERS coronavirus papain-like protease
... deubiquitinate interferon regulatory factor 3 (IRF3), which can prevent its nuclear translocation and suppress production of inter- feron β ...
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Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis
... 4 Interferon regulatory factor 3 supports Th17 cell differentiation and ...naive interferon regulatory factor – knockout (KO, irf3 −/− ) and wild-type (WT) mice ...
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Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein
... Expression plasmids. pCAGGS-NS1(SAM) and pCAGGS-NS1-R38AK41A (SAM) contain the open reading frame of NS1 from wild-type influenza A (PR8) virus in an expression vector containing a chicken -actin promotor (pCAGGS) (26). ...
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Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation
... and interferon regulatory factor 3 (IRF3) ...transcription factor IRF3 [57]. Moreover, transforming growth factor β-activated kinase 1 (TAK1)-mediated phos- ...
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