interferon regulatory factor 7
Interferon Regulatory Factor 7 Is Negatively Regulated by the Epstein-Barr Virus Immediate-Early Gene, BZLF-1
... activates interferon regulatory factor 7 (IRF-7), which is essential for production of alpha/beta interferons (IFN- ␣ /  ) and upregulates expression of ...
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The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Associates with Interferon Regulatory Factor 7 and Consequently Inhibits Beta Interferon Promoter Activity
... 8 NOTES The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 bICP0 Associates with Interferon Regulatory Factor 7 and Consequently Inhibits Beta Interferon Promoter Activity䌤 Kazi[r] ...
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Interferon Regulatory Factor 7 Mediates Activation of Tap-2 by Epstein-Barr Virus Latent Membrane Protein 1
... Transporter associated with antigen processing 2 (Tap-2) is responsible for ATP-dependent transport of peptides from the cytosol to the endoplasmic reticulum, where peptides bind to newly synthesized human leukocyte ...
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ORF45 of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Phosphorylation of Interferon Regulatory Factor 7 by IKKε and TBK1 as an Alternative Substrate
... of interferon regulatory factor 7 (IRF7), a crucial regulator of type I interferon gene expression, by blocking its virus-induced phosphorylation and nuclear ...
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Intracellular Signaling Molecules Activated by Epstein-Barr Virus for Induction of Interferon Regulatory Factor 7
... of interferon regulatory factor 7 (IRF-7) and activates IRF-7 protein by phosphorylation and nuclear ...necrosis factor receptor-associated factors (TRAFs) is needed to ...
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Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice
... Fluorescence microscopy was used to localize infiltrating cells in the CNS. CD3+ T cells were increased in num- ber and more diffusely dispersed in white matter in the spinal cord of IRF7-deficient mice with EAE, ...
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Interferon Regulatory Factor 7 Is Induced by Epstein-Barr Virus Latent Membrane Protein 1
... Interestingly, in type II latency, LMP-1 expression and an active Qp can coexist (for a review, see reference 43). One possible explanation is that LMP-1 in type II cells cannot induce IRF-7 and thus fails to ...
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Role of Interferon Regulatory Factor 7 in T Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection
... I nduction of type I interferons (IFNs) is not only essential for host innate immunity against viral pathogens but also critically in- volved in the development of virus-specific adaptive immune re- sponses, in ...
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Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3
... dominant-negative factor of both IRF3 and IRF7 and inhibits the virus-mediated transcriptional ac- tivity of the IFN promoter, showing conflicting conclusions of their ...
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Classical Swine Fever Virus Npro Limits Type I Interferon Induction in Plasmacytoid Dendritic Cells by Interacting with Interferon Regulatory Factor 7
... Innate immune activation following viral infection is depen- dent on recognition by pattern recognition receptors (PRRs) and on the production of alpha/beta interferon (IFN- ␣ /  ) (32, 38). Toll-like receptors ...
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Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling
... IRF-3 and IRF-7 are responsible for the production of type I IFN after virus sensing through a well-described biphasic ap- proach (28). While activated IRF-3 is thought to regulate the early phase of the innate ...
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Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro
... necrosis factor alpha (TNFα) regulates in vitro Aβ production and processing by trig- gering alterations in beta-site APP cleavage enzyme-1 (BACE-1) activity ...type-1 interferon alpha receptor-1 ...
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3C Protease of Enterovirus D68 Inhibits Cellular Defense Mediated by Interferon Regulatory Factor 7
... Although actively replicated in infected cells, EV-D68 induced little expression of endogenous type I IFN, ISGs, and chemokines. This is quite different from Sendai virus, which stimulated robust antiviral immunity in ...
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Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses
... E nterovirus 71 (EV71) is a positive-stranded RNA virus, which encodes a large polyprotein approximately 2,200 amino acids (aa). This precursor is processed into structural (VP1, VP2, VP3, and VP4) and nonstructural ...
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Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
... Interferon regulatory factor 1 (IRF-1), IRF-3, and IRF-7 have been tested as genetic adjuvants for influenza virus hemagglutinin (HA) and nucleoprotein vaccine ...
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Inhibition of Beta Interferon Induction by Severe Acute Respiratory Syndrome Coronavirus Suggests a Two-Step Model for Activation of Interferon Regulatory Factor 3
... (4, 7), dominant-negative interference with IRF function by viral homologues (38, 43, 73), binding to IRF-3 (51), or sequestration of the coactivator CBP ...
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Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia
... Microglia, the resident mononuclear phagocyte (MP) sys- tem of the CNS, play principal roles in the innate immune response to tissue damage and invasion of foreign organ- isms, and also in initiation and modulation of ...
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Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target
... similar to electrophoretic mobility shift assays but use an en- zyme-linked immunosorbent assay-based format. We prepared nuclear extracts from HT-29 cells that were either untreated or SeV infected. Extracts were ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... investigation. NSP1 has a calculated molecular weight of ap- proximately 54,000 and is the least conserved protein encoded by the rotavirus genome when NSP1s of different strains are compared (23, 34). The N terminus ...
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Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor
... important regulatory step unique to the response to IFN treatment is the activation of a transcriptional factor that recognizes a conserved cis-act- ing DNA element located within the regulatory ...
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