Interferon regulatory factor 8
Tumor-associated macrophage expression of interferon regulatory Factor-8 (IRF8) is a predictor of progression and patient survival in renal cell carcinoma
... Tumor-associated macrophages have been well-characterized in solid malignancies, including renal cell carcinoma and generally correlate with poor prognosis. However, the molecular mechanisms which govern intratumoral ...
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Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia
... Microglia, the resident mononuclear phagocyte (MP) sys- tem of the CNS, play principal roles in the innate immune response to tissue damage and invasion of foreign organ- isms, and also in initiation and modulation of ...
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Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation
... The novel IRF8 variants, affecting conserved residues, were functionally defective in vitro. R83, which is in the DNA- binding domain of the protein, forms hydrogen bonds with the guanine of the GAAA core. 40,41 R83 ...
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Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes
... The response of cells to virus infection includes activation of IRF-3, which cooperates with other transcriptional activators to induce IFN-␣/ genes via the ISRE enhancer (18, 26, 45). Secretion of newly synthesized ...
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<p>Transcription factor E2F1 positively regulates interferon regulatory factor 5 expression in non-small cell lung cancer</p>
... transcription factor family plays an impor- tant role in cell proliferation, differentiation and ...transcription factor family is known to be composed of 8 genes, E2F1 to E2F8, which are usually ...
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Interferon Regulatory Factor 7 Is Associated with Epstein-Barr Virus-Transformed Central Nervous System Lymphoma and Has Oncogenic Properties
... Expression and activation of IRF-7 are associated with EBV immortalization of lymphocytes. EBV efficiently immortalizes and transforms primary B lymphocytes into continually grow- ing LCLs in vitro. LMP-1 is required for ...
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Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling
... The key role played by IRF-E in IFN-␣-mediated BST-2 induc- tion suggests that IFN regulatory factors (IRFs) might be involved in BST2 transcriptional induction by type I IFN. IRFs constitute a family of nine ...
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Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection
... FIG 5 IRF-1 and type I IFN receptor facilitate induction of antiviral ISGs in MHV68-infected macrophages. Primary macrophages were derived from bone marrow of mice with the indicated genotypes. (A) Differentiated macro- ...
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Modulation of Human Herpesvirus 8/Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator Transactivation by Interferon Regulatory Factor 7
... negative regulatory factors that inactivate RTA transactivation could serve to limit the extent of lytic replication or may even lead to the abortion of lytic replication ...of interferon and IRF-7, ORF 50 ...
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Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer
... T he hallmark of the innate immune response against viruses is the activation of type I alpha/beta interferon (IFN- ␣ /  ) sig- naling in immune cells (1, 2). IFN- ␣ /  synthesis is triggered by several of the ...
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HIV Vpu Interferes with NF-κB Activity but Not with Interferon Regulatory Factor 3
... To examine a possible role of Vpu in the context of a spreading HIV infection, primary CD4 ⫹ T lymphocytes from two healthy donors were infected with a CCR5-tropic HIV Renilla Luc virus (containing the V3 loop region of ...
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Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor
... important regulatory step unique to the response to IFN treatment is the activation of a transcriptional factor that recognizes a conserved cis-act- ing DNA element located within the regulatory ...
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Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor
... Inhibition of p53-mediated upregulation of p21 and Bax protein by vIRF. Cell cycle inhibitor p21 and proapoptotic Bax have been identified as targets for p53-mediated transcrip- tional activation (11, 32). To further ...
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Interferon Regulatory Factor 3 Is a Cellular Partner of Rotavirus NSP1
... We identified IRF-3 as a cellular partner of NSP1. IRF-3 is a 427-amino-acid transcription factor that is constitutively ex- pressed in all cell types (4). IRF-3 resides latently in the cyto- plasm, and upon ...
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Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts
... Here, we have investigated the ability of infectious and non- infectious rotavirus preparations to activate DCs and to induce type I IFN. We show that MEFs respond to RRV infection by rapid NF- B activation, suggesting ...
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Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... RV14 infection fails to induce interferon-  mRNA synthesis or activation of the Jak/STAT pathway. Viral infection results in activation of the type I interferon response via the produc- tion of IFN-  . ...
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Latently Expressed Human Herpesvirus 8-Encoded Interferon Regulatory Factor 2 Inhibits Double-Stranded RNA-Activated Protein Kinase
... Distinct transcription regulation of vIRF-2 and K11 ORFs in BCBL-1 cells. We have previously shown by Northern blot- ting and RT-PCR analysis that the vIRF-2 ORF (designated K11.1) is constitutively expressed in ...
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Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures
... Enteroviruses (including coxsackieviruses) are the most fre- quently identified viruses associated with human myocarditis (17, 46); however, many other virus families have been impli- cated as well (19, 24, 39, 49). ...
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Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... Cells were lysed in an ice-cold lysis buffer containing 50 mM Tris-Cl, pH 7.5, 100 mM NaCl, 1 mM EDTA, 1% TritonX-100, 1 mM PMSF, 1 μg/ml leupeptin, and 1 μg/ml pepstain A. The protein concentration in the supernatant ...
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Rhesus Cytomegalovirus Particles Prevent Activation of Interferon Regulatory Factor 3
... Rhesus fibroblasts display an innate immune response to HCMV but not to RhCMV. Expression profiling by DNA mi- croarrays revealed previously that HCMV infection of human fibroblasts triggered massive changes in the ...
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