Interferon response factor-1 (IRF-1)
Human Herpesvirus 8 Encodes an Interferon Regulatory Factor (IRF) Homolog That Represses IRF-1-Mediated Transcription
... IFN-stimulated response elements (ISREs) via the ISGF-3g (p48) component (22, ...an IRF-1 binding site, but ISGF-3g requires additional flank- ing base pairs to bind ...(gamma ...
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Interferon Regulatory Factor-1 Regulates the Autophagic Response in LPS-Stimulated Macrophages through Nitric Oxide
... complex 1 (mTORC1) activa- tion, which mainly inhibits autophagy ...whether IRF-1- dependent NO signaling has other ef- fects on regulators of autophagy was not examined in this study and certainly ...
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Differential Regulation of Interferon Regulatory Factor (IRF)-7 and IRF-9 Gene Expression in the Central Nervous System during Viral Infection
... IFN-stimulated response element ...each IRF with unique functions. For example, IRF-2 has an inhibitory domain that represses the transcriptional activation of other IRFs such as ...
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Nuclear IRF-1 expression as a mechanism to assess “Capability” to express PD-L1 and response to PD-1 therapy in metastatic melanoma
... transcription factor interferon regulatory factor-1 (IRF-1) as a possible marker for this ...capability. IRF-1 lies immediately upstream of PD-L1 in the IFN γ ...
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Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma.
... the interferon regulatory factor (IRF) family may regulate EBNA-1 transcription by targeting an essential cis- regulatory element of Qp, ...activator IRF-1 and the closely ...
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Gamma Interferon-Induced Interferon Regulatory Factor 1-Dependent Antiviral Response Inhibits Vaccinia Virus Replication in Mouse but Not Human Fibroblasts
... ␥ response (22, 55, ...the factor responsible for inhibiting VACV replication is induced only by IFN- ␥ and independent of type I ...with IRF-E consensus sites that bind preferen- tially IRFs ...in ...
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Interferons and IRF-1 Induce Expression of the Survival Motor Neuron (SMN) Genes
... The effect of treatment with IFNs on SMNc ex- pression was examined using primary cultures of fibroblasts from skin biopsies of type-I (the most severe form) and type-II (the intermedi- ate form) patients. Immunoblotting ...
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HIV 1 Tat Recruits HDM2 E3 Ligase To Target IRF 1 for Ubiquitination and Proteasomal Degradation
... transcription factor interferon regulatory factor 1 ...decreased IRF-1 protein ...accelerate IRF-1 proteasome-mediated degradation, resulting in a quenching of ...
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The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Induces Degradation of Interferon Response Factor 3 and, Consequently, Inhibits Beta Interferon Promoter Activity
... that are necessary for activating a minimal HSV-1 thymidine kinase promoter (58). The transposon mutants used for this study express similar levels of bICP0 protein in transfected cells (58). wt bICP0 or each ...
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Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice
... Figure 1 and 1 show that induction of EAE leads to increased IRF7 gene ...its response elements, as well as with previous stu- dies [7,8,16], we found expression of IRF7 mRNA by Th1 and Th17 CD4+ T ...
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Chimeric oncogenic interferon regulatory factor 2 (IRF 2): Degradation products are biologically active
... that IRF-2 is involved in immu- nomodulation, hematopoietic differentiation, cell cy- cle regulation and ...murine IRF-2 as GST (Glutathione-S-Transferase)- IRF-2 fusion protein in ...combinant ...
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Innate immune responses induced by lipopolysaccharide and lipoteichoic acid in primary goat mammary epithelial cells
... inflammatory response induced by Toll-like receptors in primary goat MEC ...(PTGS2), interferon induced protein with tetratricopeptide repeats 3 (IFIT3), interferon regulatory factor 3 (IRF3), ...
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Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection
... IFN response in ...of IRF-7 in regulating host defense responses, we infected wild- type and IRF-7 ⫺/⫺ bone marrow-derived CD11c ⫹ mDC with WNV and assayed viral replication and IFN production ...in ...
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Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro
... (RIG- 1), melanoma differentiation-associated protein-5 (MDA- 5) and interferon gamma-inducible protein 16 (IFI-16) are all examples of TLR-independent activators of the type-1 IFN response ...
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Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation
... (Fig 1, A, and see the Methods section in this article’s Online Repository for clinical de- ...(Fig 1, B). Total CD4 1 cell, CD8 1 T-cell, B-cells, and NK cell counts were normal, and T-cell ...
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Mycobacterium avium infection induces the resistance of the interferon-γ response in mouse spleen cells at late stages of infection
... DBA/ 1, and BALB/c mice with Mycobacterium avium ...that interferon regulatory factor-2 was up-regulated and induced megakaryopoiesis in hematopoietic stem/progeni- tor cells in an inflammation ...
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Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection
... G ammaherpesviruses are ubiquitous pathogens that establish lifelong infection in a majority of the adult population and are associated with cancer (1–3). Similar to replication of other viruses, replication of ...
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HIV-1 Vpu Does Not Degrade Interferon Regulatory Factor 3
... on IRF-3 expression levels strongly argues against Vpu-mediated degradation of ...than IRF-3-dependent ...on IRF-3 expression were sparse in the studies of Doehle and cowork- ers, and the effects of ...
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Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
... the IRF family [23, ...and interferon, IRF1 acts as a transcriptional activator of specific IFN- stimulated genes that mediate diverse functions including cellular responses to inflammation, programmed cell ...
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Whole blood expression profiling from the TREAT trial: insights for the pathogenesis of polyarticular juvenile idiopathic arthritis
... We used the Ingenuity Pathway Analysis (IPA) software (Ingenuity Systems®, Redwood City, CA, USA; IPA Summer Release, June, 2015) for network analysis, with differentially expressed (DE) genes as input following the ...
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