interferon signaling
Tumor Interferon Signaling Initiates And Sustains A Multigenic Resistance Program To Immune Checkpoint Blockade
... this interferon driven resistance mechanism primarily occurs in ICB resistant tumors and not in ICB responsive ...II interferon signaling allows tumors to acquire STAT1-related epigenomic changes and ...
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Suppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin
... suppress interferon signaling, including viral non- coding RNAs that target the host immune response and the ability of cells to respond to interferon (reviewed in reference ...in interferon ...
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Andes and Prospect Hill Hantaviruses Differ in Early Induction of Interferon although Both Can Downregulate Interferon Signaling
... initial interferon induction by these two viruses or, in addition, that signaling through the Jak/Stat pathway is blocked by ANDV ...in interferon in- duction, both ANDV and PHV were found to inhibit ...
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Marburg Virus VP40 Antagonizes Interferon Signaling in a Species-Specific Manner
... Expression of VP40 alone is able to drive the formation of VLPs that bud from the cell membrane. Filoviral VP40s have well-characterized late domains important for the budding process: ZEBOV VP40 possesses two late ...
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Long-Distance Interferon Signaling within the Brain Blocks Virus Spread
... The strong upregulation of ISGs we observed raises the ques- tion of the cellular source of IFN production. We and others have previously shown that glia, microglia, and neurons can participate in IFN signaling ...
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Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection
... the signaling pathways activated by the different type I IFNs, which may be related to their levels of ...differential signaling affects the immune response and the outcome of infection (51, ...downstream ...
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Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses
... Cleavage between NS4A and NS4B is required for IFN an- tagonism. We previously reported that expression of DEN-2 NS4A inhibits IFN- ␣ /  signaling and that coexpression of NS4A and NS4B results in enhanced ...
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Dengue Virus Inhibits Alpha Interferon Signaling by Reducing STAT2 Expression
... Alpha/beta interferon (IFN- ␣ /  ) is a key mediator of innate antiviral responses but has little effect on the established replication of dengue viruses, which are mosquito-borne flaviviruses of immense global ...
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Annexin V Incorporated into Influenza Virus Particles Inhibits Gamma Interferon Signaling and Promotes Viral Replication
... Packaged A5 inhibits IFN-␥ receptor signaling. A5 associates with the IFN- ␥ receptor and downregulates its signaling (16). We therefore investigated whether A5 incorporated into IAV particles (A/WSN/33 ...
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Porcine Epidemic Diarrhea Virus Infection Inhibits Interferon Signaling by Targeted Degradation of STAT1
... STAT1 plays a critical role in the control of PEDV replica- tion. Given that STAT1 degradation is induced by PEDV infec- tion, and since the degradation of STAT1 has been shown to con- tribute to the blockage of IFN ...
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Type I Interferon Signaling Prevents Hepatitis B Virus-Specific T Cell Responses by Reducing Antigen Expression
... IFN-I signaling negatively regulated HBV- specific CD8 ⫹ T cell responses by reducing antigen ...IFN-I signaling, and HBV-specific CD8 ⫹ T cell responses ...
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Ebolavirus VP24 Binding to Karyopherins Is Required for Inhibition of Interferon Signaling
... alpha/beta interferon (IFN- ␣ /  ) and cellular responses to IFN- ␣ /  / ␥ (7, 8, 10, 11, ...of interferon regulatory factors by blocking inter- feron regulatory factor 3 (IRF-3) kinases IKKepsilon and ...
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Inhibition of Interferon Signaling by the Kaposi's Sarcoma-Associated Herpesvirus Full-Length Viral Interferon Regulatory Factor 2 Protein
... vIRF-2 protein inhibits IRF-1-induced ISRE signaling. IFN- ␣ or IFN- treatment of cells induces formation of the ISGF-3 transcription complex that activates ISRE-containing promoters. IRF-1 can also ...
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Virus-Activated Interferon Regulatory Factor 7 Upregulates Expression of the Interferon-Regulated BST2 Gene Independently of Interferon Signaling
... The key role played by IRF-E in IFN-␣-mediated BST-2 induc- tion suggests that IFN regulatory factors (IRFs) might be involved in BST2 transcriptional induction by type I IFN. IRFs constitute a family of nine ...
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Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1
... Western blotting. Total cellular proteins were prepared using radio- immunoprecipitation assay (RIPA) buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 1 mM EDTA, 1% Triton X-100, 0.1% SDS, 1⫻ Roche protease inhibitor ...
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Differential Induction of Apoptosis, Interferon Signaling, and Phagocytosis in Macrophages Infected with a Panel of Attenuated and Nonattenuated Poxviruses
... beta interferon (IFN-) mRNA expression was ob- served in macrophages after infection with the attenuated strain MVA and to a lesser degree with NYVAC but not with other non- attenuated ...
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Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons
... I interferon (IFN) and are crucial to controlling HSV-1 ...antiviral signaling in TG neurons produce an unorthodox autophagic ...antiviral signaling, the presence of viral genome, and the absence of ...
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Inhibition of Alpha Interferon Signaling by Hepatitis B Virus
... We have previously shown that hepatitis C virus, a member of the Flaviviridae family, induces the upregulation of PP2Ac in vivo (liver biopsy studies of HCV transgenic mice) and in vitro (tetracycline-regulated HCV ...
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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... downstream signaling is new ...alternative signaling mechanisms as outlined in ...I interferon signaling in IBC not only sheds light on the molecular underpinnings of the disease but also ...
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Age-associated mRNA expression changes in bovine endometrial cells in vitro
... between endometrial cells obtained from young and aged cows. These findings indicated that the influence of IFNT is almost the same between endometrial cells ob- tained from young and aged cows. Gierek et al. [50] re- ...
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