Interferon stimulated gene
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection
... CH25H is a 233-amino-acid protein that catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (4). CH25H mRNA expression is induced following infection by reovirus, consistent with the prior identification of the ...
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90K, an interferon stimulated gene product, reduces the infectivity of HIV 1
... Background: In response to viral infections, interferons induce the transcription of several hundred genes in mammalian cells. Specific antiviral functions, however, have only been attributed to a few of them. ...
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DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture
... of interferon (IFN) efficiently inhibit hepatitis C virus (HCV) replication in vitro and in ...alter interferon-stimulated gene (ISG) induction after IFN treatment but inhibited HCV ...
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Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages
... ABSTRACT Viruses manipulate the complex interferon and interferon-stimulated gene (ISG) system in different ways. We have previously shown that HIV inhibits type I and III interferons in its ...
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Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway
... Interferon-stimulated gene 15 (ISG15) is a cytokine secreted from monocytes and lymphocytes upon infection or the treatment of Type I interferon (IFN-α/β) ...
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Interferon-stimulated gene 15 in hepatitis B-related liver diseases
... of Interferon-stimulated gene 15 (ISG15) polymorphisms, ISG15 serum levels and expression with HBV-related liver ...the gene were screened for polymorphisms in 766 HBV-infected patients and in ...
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The Epstein-Barr Virus SM Protein Induces STAT1 and Interferon-Stimulated Gene Expression
... times after SM induction. As shown in Fig. 6A, SM expression led to an increase in STAT1 mRNA levels. The increase began relatively soon after SM expression but increased significantly after 32 h, consistent with ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
... vIRF1 expression decreases total cellular ISG15 conjugation to proteins. We demonstrated that vIRF1 associates with the ISG15 E3 ligase HERC5; however, the functional significance of this interaction remained unclear. To ...
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Δγ134.5 Herpes Simplex Viruses Encoding Human Cytomegalovirus IRS1 or TRS1 Induce Interferon Regulatory Factor 3 Phosphorylation and an Interferon-Stimulated Gene Response
... Suppression of PKR activity does not restore wild-type HSV virulence, and C134 is aneurovirulent (27, 36). It is possible that induction of IRF3-mediated antiviral gene expression compen- sates for PKR evasion in ...
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Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3
... I interferon (IFN), represented by IFN- ␣ and IFN-  ...IFN-stimulated gene (ISG) proteins, which act as antivirals. The IFIT (interferon-induced proteins with tetratricopeptide repeats) ...
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Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
... reporter gene expression was not dependent upon gene expression from other genome segments, and under these conditions, ISG20 could not mediate indirect inhibition by targeting another genome ...
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IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10
... IRAV associates with P bodies, as evidenced by interactions with P body-associated proteins (MOV10 and UPF1) and colocalization with P body markers (DCP1a, XRN1, and DDX6). P bodies are discrete cytoplasmic structures ...
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Screening of Medicinal Plants: Rheum emodi Induces Interferon Stimulated Gene 56 (IFIT1), a Antiviral Protein
... ISG56 is a cytoplasmic protein which expression is upregulated more than 10 fold during viral infection. It belongs to a group of proteins called IFIT genes family protein. Recent studies have also shown that by ...
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Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo
... alpha/beta interferon (IFN- ␣ /  ) system acting as an important component of this ...containing interferon-stimulated response elements (9, ...of interferon-stimulated genes (ISGs) ...
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Characterization of the Elements and Proteins Responsible for Interferon-Stimulated Gene Induction by Human Cytomegalovirus
... of interferon- stimulated genes (ISGs) in a viral envelope-cell membrane fusion-dependent ...two interferon response elements, the interferon-stimulated response element (ISRE) and the ...
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The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses
... Restriction of alphaviruses by Ifitm proteins in cell culture. Al- though expression of IFITM genes inhibits infection of several different genera of viruses (7–16), their antiviral activities against alphaviruses have ...
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Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon Stimulated Gene Responses
... ChIP-PCR. ChIP analysis was performed using the EpiTect ChIP OneDay kit (Qiagen). Briefly, infected Calu3 cells were cross-linked, har- vested, and frozen at ⫺ 80°C. Cells were then lysed and chromatin sheared via ...
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The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis
... The interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several different enveloped vi- ruses in cell culture by virtue of their ability to restrict entry and fusion from late ...
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Type I interferonopathies in pediatric rheumatology
... IRF: interferon regulatory factors; ISG15: interferon-stimulated gene 15; JAK: Janus kinase; JASL: Japanese autoinflammatory syndrome with lipodystrophy; JMP: joint contractures, muscle ...
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Targeting tumor-associated macrophages to combat pancreatic cancer
... Ang-2, angiopoietin-2; CSC, cancer stem cells; EMT, epithelial-mesenchymal transition; FGF, fibroblast growth factor; ISG-15, interferon-stimulated gene 15; MDSC, myeloid-derived suppres[r] ...
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