Interferon stimulated gene 15
Interferon-stimulated gene 15 in hepatitis B-related liver diseases
... of Interferon-stimulated gene 15 (ISG15) polymorphisms, ISG15 serum levels and expression with HBV-related liver ...the gene were screened for polymorphisms in 766 HBV-infected patients ...
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Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits the Antiviral Function of Interferon-Stimulated Gene 15
... I interferon (alpha/beta interferon [IFN- ␣ /  ]) stimulates the expression of interferon-stimulated gene 15 (ISG15), which encodes a ubiquitin-like protein, ...of ...
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Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway
... Interferon-stimulated gene 15 (ISG15) is an important cytokine that has been reported in carcinogenesis. However, we found that ISG15 and de-ISGylase USP18 were induced by several anti-cancer ...
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Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant Hepatitis
... Coronaviruses express a deubiquitinating protein, the papain-like protease-2 (PLP2), that removes both ubiquitin and the ubiq- uitin-like interferon (IFN)-stimulated gene 15 (ISG15) protein ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway
... cellular interferon regulatory factors (IRFs), known as viral IRFs (vIRFs), participate in evasion of the host interferon (IFN) ...feron-stimulated gene 15 (ISG15) E3 ligase, HERC5, in ...
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Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo
... alpha/beta interferon (IFN- ␣ /  ) system acting as an important component of this ...containing interferon-stimulated response elements (9, ...of interferon-stimulated genes (ISGs) ...
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Type I interferonopathies in pediatric rheumatology
... IRF: interferon regulatory factors; ISG15: interferon-stimulated gene 15; JAK: Janus kinase; JASL: Japanese autoinflammatory syndrome with lipodystrophy; JMP: joint contractures, muscle ...
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Targeting tumor-associated macrophages to combat pancreatic cancer
... Ang-2, angiopoietin-2; CSC, cancer stem cells; EMT, epithelial-mesenchymal transition; FGF, fibroblast growth factor; ISG-15, interferon-stimulated gene 15; MDSC, myeloid-derived suppres[r] ...
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Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages
... plasm stimulated second-phase ISG expression via the RNA sensor RIGI or the DNA sensor cGAS (22), and possibly IFI16 (23), we knocked down MAVS (the RIGI adaptor) and STING (the cGAS/IFI16 adaptor) 3 days prior to ...
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Cytomegalovirus InducesInterferon-Stimulated Gene Expression and Is Attenuated by Interferon in the Developing Brain
... As CMV is a particularly damaging virus for the developing brain, we next asked whether less-mature embryonic brain cells show any sign of protection from mCMV infection after IFN treatment. Here we used cells from ...
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Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3
... least 15 h of infection; (ii) it did not react with purified PIV3 virions (data not shown); and (iii) it did not react with un- infected cell extracts or extracts made at early stages of infection ...
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The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses
... mortality following IAV infection (19–21). However, some stud- ies have questioned the significance of this truncated IFITM3 al- lele in the susceptibility to IAV and other viral infections (22, 23). The mechanisms by ...
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Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
... ISG20 has specific antibunyaviral activity. Many divergent viruses are classed as bunyaviruses (1, 2). To further investigate the antiviral spectra of the selected ISGs against bunyaviruses, we screened the ability of ...
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Characterization of the Elements and Proteins Responsible for Interferon-Stimulated Gene Induction by Human Cytomegalovirus
... It is important to identify the VRS-binding proteins, because they are candidate proteins responsible for the induction of ISGs after HCMV-infection. The results from this study sug- gest that it is unlikely that the ...
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Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species
... the interferon type I (IFN-I) response has been shown to rely on posttranslational modification by ubiquitin (Ub) and Ub-like interferon-stimulated gene product 15 (ISG15) to stabilize, ...
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Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells
... The ability of RSV to influence the expression of cell surface receptors may provide an important clue to the cellular biology of viral infection. Through this mechanism, a virally infected cell may have a cellular ...
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DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture
... IFN-␥-induced gene expression as well as the inhibition of HCV replication upon DDX60L expression sug- gested that DDX60L acts as a direct effector protein inhibiting HCV replication, although we did not find a ...
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Pegylated leptin antagonist with strong orexigenic activity in mice is not effective in chickens
... were stimulated with human leptin and with interferon αA (IFNA2), both activating the reporter gene through the cLEPR or an endogenous IFNR, respectively (Hen et ...reporter gene in the ...
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25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection
... ABSTRACT Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus rep- lication and dissemination. ...
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Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems
... In our experimental system, ex vivo stimulation for 4 h of whole blood from healthy donors with rhIFNα was sufficient to induce relatively high levels of expres- sion of all six ISGs tested. The magnitude of relative ...
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