Interferon-β
Cost analysis of glatiramer acetate versus interferon-β for relapsing-remitting multiple sclerosis in patients with spasticity: the Escala study
... during interferon-β vary from ...to interferon-β [32, ...with interferon (15,589€), and the combined treatment with both interferon and glatiramer acetate (21,539€) ...the ...
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Erratum to: Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB
... adapter-inducing interferon- β (TRIF) deficiency attenuates microglial inflammatory factor ...showing interferon (IFN)- β mRNA expressed in the control, and at 12, 24, and 36 hours in WT and ...
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Prolactin in combination with interferon-β reduces disease severity in an animal model of multiple sclerosis
... murine interferon- β resulted in (days 9 to 17 group) or trended towards (days 9 to 33 group), a greater amelioration of clinical signs of EAE, compared to either treatment alone or to vehicle ...with ...
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Variability in detection and quantification of interferon β-1b–induced neutralizing antibodies
... A number of CPE assays have been developed using a variety of cell lines and viruses to determine the titer of an IFN sample. The addition of neutralizing antibodies to the interferon allows the titer of ...
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Long-term Outcome of Schilder Disease Treated With Interferon-β
... response of tumefactive lesions to corticosteroid is not satisfactory. Intravenous immunoglobulins have also been used more or less successfully as a rescue therapy. 2,21 There have been scarce data regarding DMT for ...
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In vitro inhibition of monkeypox virus production and spread by Interferon β
... RESEARCH Open Access In vitro inhibition of monkeypox virus production and spread by Interferon b Sara C Johnston1*, Kenny L Lin1, John H Connor3, Gordon Ruthel2, Arthur Goff1 and Lisa E Hensley1 Abst[.] ...
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Interferon β attenuates lung inflammation following experimental subarachnoid hemorrhage
... IFN: interferon; MIP: macrophage inflammatory protein; MPO: myeloperoxidase; MV: mechanical ventilation; NPE: neurogenic pulmonary oedema; RT: reverse transcriptase; SAH: subarachnoid hemorrhage; VCAM: vascular ...
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Arthritis suppression by NADPH activation operates through an interferon-β pathway
... Ifn β was increased after injection with ...Ifn β in DA rats at day 10 after treatment with phytol, RNA samples produced from all four separate experiments was analyzed for Ifn α and Ifn β expression ...
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Superior MRI outcomes with alemtuzumab compared with subcutaneous interferon β-1a in MS
... After 2 years, the benefits of alemtuzumab vs SC IFN- b -1a were even more appar- ent, with significantly better outcomes emerging both in treatment-naive patients and in those with an i[r] ...
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An Anti-Inflammatory Azaphenothiazine Inhibits Interferon β Expression and CXCL10 Production In KERTr Cells
... Hitherto, our studies have shown that the azaphenothiazine derivative, DQT, exerts an immunosuppressive effect in in vivo models of delayed-type hypersensitivity to ovalbumin, carrageenan-induced footpad inflammation [9] ...
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Interferon β for treatment of rheumatoid arthritis?
... IFNs are a family of naturally secreted proteins with immunomodulatory functions. They enhance the ability of macrophages to destroy tumour cells, viruses and bacte- ria. The IFNs are divided into two types. Type 1 IFNs ...
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Promyelocytic leukemia protein isoform II promotes transcription factor recruitment to activate interferon β and interferon responsive gene expression
... Depletion of PML-II reduces IFN-  expression. In order to in- vestigate the function of PML-II in interferon expression, we first established conditions for transient knockdown of PML-II using previously ...
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Pathogenic Effects of IFIT2 and Interferon β during Fatal Systemic Candida albicans Infection
... Pathogenic Effects of IFIT2 and Interferon � during Fatal Systemic Candida albicans Infection Marcin Stawowczyk,a Shamoon Naseem,a Valeria Montoya,a Darren P Baker,b* James Konopka,a Nancy C Reicha aD[.] ...
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Schweninger, Christian (2012): Die Rolle von zytosolischer DNA in der Pathogenese des Diabetes mellitus Typ 1. Dissertation, LMU München: Medizinische Fakultät
... 81 die mRNA-Expression des TLR3-Gens ließ sich durch diese Stimulantien etwas anheben, während sich die der TLR7- und TLR9-Gene kaum haben beeinflussen lassen. Diese Erkenntnisse könnten wieder ein Hinweis darauf sein, ...
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Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: an open-label two-arm trial
... as interferon gamma (IFN γ) and interleukin (IL)-17 by CD4 + T cells [22], which promote the disruption of blood–brain barrier in- tegrity, allowing egress of activated T cells into the central nervous system ...
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Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis
... These findings suggest that double-stranded RNAs are gen- erated in SARS-CoV-infected macrophages. Double-stranded RNA is a potent inducer of IFN-  , triggering cell signaling pathways such as those mediated through ...
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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... an interferon response, STATs are ini- tially phosphorylated and IFNα signaling is initiated and re- solved quickly, but during chronic inflammation STATs lose their phosphorylation status even in the presence of ...
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Neutralizing antibodies and fatigue as predictors of low response to interferon-beta treatment in patients with multiple sclerosis
... administration as opposed to intramuscular administra- tion [8,13,14], the dose treatment [7,11] and the different follow-up durations. Moreover, a positive NAb status may be reversible over time [12,13,15]. The origin ...
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The clinical potential of blood-proteomics in multiple sclerosis
... In the first case, the differentially expressed proteins were: Rho-GDI2, Rab GDIβ (Rab2) and Cofilin 1. In the second case, the differentially expressed proteins were: Cortactin and the Fibrinogen β Chain ...
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The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention
... once activated – namely a phagocytic phenotype (innate activation) or the aforementioned antigen-presenting phenotype (adaptive activation) that is seen post TBI. When challenged with certain pathogen-associated mo- ...
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