Interleukin-1 Receptor
Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns
... [11–14]. Interleukin-1 receptor antagonist (IL-1Ra) has already demonstrated a protective perinatal efficacy on several organs, especially the brain, exposed to inflammation induced by bacterial ...
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Production of interleukin 1 receptor antagonist by human articular chondrocytes
... Interleukin-1 receptor antagonist (IL-1Ra) is a natural IL-1 inhibitor possessing anti-inflammatory properties. IL-1Ra is produced as different isoforms, one secreted (sIL-1Ra) and three ...
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Role of polymorphisms of toll like receptor (TLR) 4, TLR9, toll interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
... extracellular receptor modules and initiating inflammatory signalling pathways through an intracellular domain ...(IFN)-γ, interleukin (IL)-12 and tumour ne- crosis factor (TNF) that should favour the ...
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Inhibition of Osteoarthritis in Rats by Electroporation with Interleukin 1 Receptor Antagonist
... efficacy. Interleukin-1 (IL-1) is the major cytokine involved in the pathology of OA [19] ...of interleukin-1 receptor antagonist (IL-1Ra), a specific inhibitor that binds to the ...
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Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure
... The research subjects included in this study were divided into 15 patients per group. Inclusion criteria were as follows: having status epilepticus, febrile seizure, or febrile and permission from the subject’s parents ...
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Interleukin 1 receptor antagonist in normal and psoriatic epidermis
... antagonist (IL-1ra) and IL-1 alpha were present in overlapping peaks. Further fractionation of the normal epidermal cytosol by anion exchange chromatography separated these two molecules, revealing the IL-1 ...
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Role of Interleukin 1 Alpha (IL 1α) and Interleukin 1 Receptor Antagonist (IL 1RA) in Pathogenesis of Juvenile Idiopathic Arthritis and Adult Onset Rheumatoid Arthritis of Iraqi Patients
... occurring receptor antagonist for IL-1) showed no significant variation between JIA or RA patients and controls, and distributing the patients according to disease activity or severity did not change such ...
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Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist
... IL-1RI receptor domains, whereas the Ilantide sequence motif includes only two residues from the binding site that is involved in the interaction with the Ig3 domain (see Figure ...
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Targeting interleukin-1 receptor-associated kinase 1 for human hepatocellular carcinoma
... The pathogenesis of HCC is complex and diverse, in- volving different signal pathways, such as Wnt [33, 34], MAPK [30, 35, 36] and PI3K/AKT [31]. Recent studies also showed that inflammation signal pathways were closely ...
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Oligonucleotides antisense to the interleukin 1 receptor mRNA block the effects of interleukin 1 in cultured murine and human fibroblasts and in mice
... Phosphodiester and phosphorothioate oligodeoxynucleotides (18 mers) were constructed antisense to sequences of the recently cloned murine and human IL-1 receptors. Murine antisense oligonucleotides inhibited ...
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MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling
... Prior to recent breakthroughs, it was believed that the majority of DNAs were transcribed to mRNAs and then translated into proteins. The remaining RNAs not coding for protein were either ribosomal RNAs, transfer RNAs, ...
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Intracellular Function of Interleukin-1 Receptor Antagonist in Ischemic Cardiomyocytes
... Figure 1. Expression of IL-1Ra in hearts explanted from patients with end stage ischemic heart disease. (a) Immunofluorescence co- staining for IL-1Ra and PECAM-1. Several cardiomyocytes show positive ...
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Interleukin 1 receptor antagonist A new member of the interleukin 1 family
... This review has summarized recent information derived from many laboratories on the discovery, characteristics, and properties of a new member of the IL-1 family, IL-1 receptor antagonist. In ...
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The inhibitory activity of human interleukin 1 receptor antagonist is enhanced by type II interleukin 1 soluble receptor and hindered by type I interleukin 1 soluble receptor
... monocytes/macrophages. At the inflammatory site, IL-1 is a potent inducer of the production of prostaglandin E2 (PGE2) and metalloproteinases on fibroblast-like cells, thus triggering tissue damage. The biological ...
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Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
... As it is well known that the synaptic localisation of receptors and ion channels, together with their protein- protein interactions, are modulated in response to var- ious stimuli, and that they undergo dynamic changes ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... I interleukin-1 (IL-1) receptor (IL-1RI) signaling complex using immunoprecipitation and tandem mass ...to interleukin-1 receptor-associated kinase ...IL-1 ...
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The relationship between TRAF6 and tumors
... factor receptor; TRAFs: Tumor necrosis factor receptor- related factors; TNFSF: Tumor necrosis factor superfamily; TLR/ILR: Toll-like/ interleukin-1 receptor; TRAF6: Tumor necrosis ...
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Early lactate clearance is associated with biomarkers of inflammation, coagulation, apoptosis, organ dysfunction and mortality in severe sepsis and septic shock
... (interleukin-1 receptor antagonist, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor-alpha, intercellular adhesion molecule-1, high mobility group box- ...
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Skin Targeting Approaches in Cosmetics
... Factor Receptor (EGFr), interleukin-1 receptor (IL- 1r), Tumor Necrosis Factor Receptor (TNF), Plate- let-Derived Growth Factor Receptor (PDGFr) and Platelet-Activating Factor ...
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IL 1ra delivered from poly(lactic co glycolic acid) microspheres attenuates IL 1β mediated degradation of nucleus pulposus in vitro
... degeneration. Interleukin-1 receptor antagonist (IL-1ra) is an endogenous inhibitor of IL-1b in vivo, where it acts by competitively blocking the bind- ing of IL-1b to IL-1 receptors on ...
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