interleukin-11
Siegmund, Annette (2008): Interleukin-11 - analog zu Interleukin-6 - ein direkter Modulator der Nebennierenrinde: In vitro Versuche mit Interleukin-11 und Interleukin-6 an der murinen Nebennierenrinde und der adrenokortikalen Tumorzelle Y-1. Dissertation, LMU München: Medizinische Fakultät
... humane Interleukin-11 wurde erstmals 1990 als eine weitere Aktivität - neben dem bekannten Interleukin-6 - im Medium einer durch IL-1 stimulierten Knochenmarkszelllinie von Primaten, PU-34, von Paul ...
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Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infection
... Interleukin-11 (IL-11), a well-known anti-inflammatory factor, provides protection from intestinal epithelium damage caused by physical or chemical factors. However, little is known of the role of ...
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Regulated overexpression of interleukin 11 in the lung Use to dissociate development dependent and independent phenotypes
... Standard overexpression transgenic approaches are limited in their ability to model waxing and waning diseases and frequently superimpose development-dependent and -inde- pendent phenotypic manifestations. We used the ...
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Interleukin-11 Promotes the Progress of Gastric Carcinoma via Abnormally Expressed Versican
... Versican, a ubiquitous component of the extracellular matrix (ECM), accumulates both in tumor stroma and cancer cells and is highly regulated by various cytokines. The aberrant expression of versican and its isoforms is ...
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Interleukin 11: a new cytokine critical for osteoclast development
... however, does not influence osteoclastogenesis in the estrogen-replete state, suggesting that other cytokines might be responsible for osteoclast development under physiologic circumstances. We report here that ...
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Interleukin 11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions
... IL- 11 are probably best explained by the combination of reduced levels of proinflammatory cytokines in skin and the presence of fewer T cells, especially those with- in the ...
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Results of a phase I/II randomized, masked, placebo controlled trial of recombinant human interleukin 11 (rhIL 11) in the treatment of subjects with active rheumatoid arthritis
... The mechanism of action of rhIL-11 in the treatment of active RA most likely results from the ability of rhIL-11 to reduce levels of TNF- α , IL-1 β , and IL-12 p40. The anti- inflammatory activity of ...
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MTERFD1 promotes cell growth and irradiation resistance in colorectal cancer by upregulating interleukin-6 and interleukin-11
... To verify the correlation between IL-6 and IL-11 and MTERFD1, the IL-6 and IL-11 protein levels in the culture supernatants were assayed via ELISA in the MTERFD1-OE and MTERFD1-KD cells. Overexpression of ...
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Detection of receptors for interleukin 6, interleukin 11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells
... Besides previously recognized (or suspected, in the case of OSMRb) a and b subunits for this cytokine receptor family, we have detected a heretofore unrecognized form of gp130, with a very small, if any, response to IL-6 ...
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Interleukin 11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness
... we measured the IL-11 levels in pediatric nasal aspirates that had been sent to our Clinical Virology Laboratory for stan- dard clinical evaluations. These studies demonstrated that, in contrast to controls, ...
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Evaluating the Effect of Oprelvekin on Cardiac Repolarization in Subjects with Chemotherapy-Induced Thrombocytopenia: An Observational Chart Review of a Phase 2 Clinical Trial in Laredo, Texas Soriano RA *1 and Gonzalez M 2
... This study tested for the cardiac effects of Oprelvekin, recombinant human interleukin-11, a thrombopoietic growth factor, in patients afflicted with chemotherapy-induced thrombocytopenia (platelet ...
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Original Article Morphoproteomics provides support for TGF-β pathway signaling in the osteoclastogenesis and immune dysregulation of osteolytic Langerhans cell histiocytosis
... Because of these existing data that support both clonal and dysmaturation/immune dys- regulation-associated processes in the etio- pathogenesis of osteolytic LCH, we decided to focus on defining the factors common to its ...
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Determination of Changes in Blood Biomarker Levels in Antipsychotic Polypharmacy and Aripiprazole Monotherapy in Patients With Long-term Schizophrenia
... of Interleukin 2 (IL-2), Interleukin 6 (IL-6), Interleukin-1 Receptor Antagonist (IL-1RA), and Brain-derived Neurotrophic Factor (BDNF) biomarkers were compared in antipsychotic polypharmacy and 6 ...
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Anti interleukin 13 and anti interleukin 4 agents versus placebo, anti interleukin 5 or anti immunoglobulin E agents, for children and adults with asthma
... cytokines interleukin-4, -5, and -13 play a central role in the pathophysiology (de Groot ...targeting interleukin-4, -5, and -13, have been developed; the evidence around anti-interleukin-5 ...
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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview
... intracellular events, whereas IL-1β act as an extracellular protein. It has been reported that the levels of IL-1α, IL-1β and also IL-1/IL-receptor antagonist (RA, anti in- flammatory cytokine) have been increased in ...
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Simvastatin nanoparticles attenuated intestinal ischemia/reperfusion injury by downregulating BMP4/COX-2 pathway in rats
... of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α, and nitric oxide (NO) were checked, and the dry/wet intestine ratios, superoxide dismutase activity, ...
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Immunotherapy of brain metastases: breaking a “dogma”
... IL: Interleukin; IL-10: Interleukin-10; IL-1 β : Interleukin-1 β ; IL- 23: Interleukin-23; IL-6: Interleukin-6; IL-8: Interleukin-8; Ir: Immune-related; iRANO: Immunotherapy ...
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Anti inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti inflammatory cyclooxygenase 2 (COX 2) pathway
... MGDG and DGDG (mono- and digalactosyldiacylgly- cerol galactolipids with a high content of polyunsatu- rated fatty acids, mainly omega-3 s) are the most widespread non-phosphorous polar lipids in the bio- sphere and ...
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Vasoactive intestinal peptide ameliorates renal injury in a pristane-induced lupus mouse model by modulating Th17/Treg balance
... affects the regulation strategies of both the innate and adaptive immune systems [21, 22]. Therefore, it has emerged as a potential candidate for the treatment of various autoimmune and inflammatory diseases; VIP has ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... and systemic effects of which bridge the innate and adaptive immune systems (1). There are two active IL-1 molecules: IL-1 ␣ and IL-1  with similar three-dimensional structures (2, 3) that induce similar biological ...
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