Interleukin-17A (IL-17A)
Association between Interleukin-32 and Interleukin-17A Single Nucleotide Polymorphisms and Serum Levels with Polycystic Ovary Syndrome
... inflammation. Interleukin-17A (IL-17A) and Interleukin-32 (IL-32) are two members of the pro- inflammatory cytokines which act as significant components of the immune system ...
9
Heterogeneous expression pattern of interleukin 17A (IL 17A), IL 17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti IL 17 therapy?
... the IL-17A antibody, we used a rabbit polyclonal IL-17A antibody (Insight Biotechnology, Wembley, UK) to investigate colocalisation with MCT, CD31 and ...anti- IL-17F antibodies showed ...
10
Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A
... human IL-17A (R&D Systems, Minneapolis, MN, USA), and splenic B-cells were isolated to generate a fragment antigen-binding (Fab)-expressing phage display library using standard DNA ...
12
Interleukin-17A as a Biomarker for Bovine Tuberculosis
... produced IL-17A in response to ...PPD-specific IL-17 mRNA responses at 60 and 90 days after experimental ...increased IL-17A and IL-22 expression within tuberculous granulomas ...
13
Mechanistic rationales for targeting interleukin 17A in spondyloarthritis
... the IL-17A pathway plays a predominant role in the promotion of osteoclasto- genesis in patients with SpA, and levels of circulating Th17 cells observed in the peripheral blood are much higher and more ...
9
Impact of tobacco smoking on cytokine signaling via interleukin-17A in the peripheral airways
... via IL-17A protein in the peripheral airways, whereas the impact of COPD per se remains ...the IL-17A-mediated control of antibacterial activity originating from ...
8
Elevated serum levels of interleukin-17A in children with autism
... that IL-17A is upregu- lated and involved in the pathogenesis of various autoimmune inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis ...addition, ...
6
The relationship between asymptomatic organ damage, and serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Interleukin-17A (IL-17A) levels in non-diabetic hypertensive patients
... 2005 interleukin-17 (IL-17) was known as a cytokine produced only by T helper 17 [11], but more recent stud- ies have shown that it can be produced by macrophages, dendritic cells, natural killer cells, ...
9
Intraocular Levels of Interleukin 17A (IL-17A) and IL-10 as Respective Determinant Markers of Toxoplasmosis and Viral Uveitis
... uveitis). Interleukin 1  (IL-1  ) levels were markedly increased in viral uveitis, as were IL-10 levels, whereas IL-17A levels were augmented in toxoplasmic ...
7
Polymorphisms in interleukin 17A gene and coal workers’ pneumoconiosis risk in a Chinese population
... other IL- 17 producing cells, IL-17 cytokine family consists of six members including IL-17A (IL-17), IL-17B, IL-17C, IL- 17D, IL-17E (also known as ...
8
Efficacy and safety of monoclonal antibodies targeting interleukin-17 pathway for inflammatory arthritis: a meta-analysis of randomized controlled clinical trials
... Database search was performed in PubMed using the keywords “interleukin-17A” and “rheumatoid arthritis”. Eligible studies were selected based on the following criteria: 1) study design: randomized, ...
7
Secukinumab, an Interleukin-17A Inhibitor, in Ankylosing Spondylitis
... Blood samples were collected at baseline and immediately before dose administration at weeks 4, 16, 24, and 52 for assessment of secukinumab immunogenicity with the use of a bridging imm[r] ...
15
Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis
... Multiple studies have demonstrated the immunoregu- latory properties of MSCs. MSCs profoundly affect the immune response through interactions with the cellular components of the innate (natural killer (NK) cells) and ...
14
Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance
... and IL-4 (11B11) were purchase from Bio X Cell, Inc (West Lebanon, USA) and eBioscience (San Diego, CA, ...mouse IL-6 were from ProSpec (New Jersey, USA), recombinant mouse IL-12p70 and recombinant ...
21
Aberrant expression of interleukin 23 regulated miRNAs in T cells from patients with ankylosing spondylitis
... Data are represented as the median and IQR or number (%) as appropriate. Simple and multiple linear regression analyses were used to calculate the correlation coefficients among different clinical parameters and ...
10
<p>Therapeutic Potential of Ixekizumab in the Treatment of Ankylosing Spondylitis: A Review on the Emerging Clinical Data</p>
... mainly IL-23. Here, AS is mostly seen as an autoin fl ammatory disease. IL-23 trigs Th17 response, driv- ing to IL-17 expression, frequently observed in ...regarding IL-12/23 and IL-17 ...
11
Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity
... that IL-10, produced mainly by renal-infiltrated Tregs and tolerogenic dendritic cells, efficiently reduced CDDP-induced AKI and associ- ated inflammation ...tration, IL-10 producing Tregs migrated into ...
14
Long term efficacy and safety of secukinumab 150 mg in ankylosing spondylitis: 5 year results from the phase III MEASURE 1 extension study
... Secukinumab, a fully human monoclonal antibody that directly inhibits interleukin IL-17A, has shown significant and sustained efficacy in the treatment of AS across phase III MEASURE stu[r] ...
8
Original Article Efficiency of IL-17a on neutrophil apoptosis and regulatory mechanisms in septic rats
... Murine IL-17a (Peprotech Com- pany, Rocky Hill, NJ, USA); soluble Fas Elisa Kit (Calvin Biological Technology ...China); IL-17Elisa Kit (Calvin Biological Technology ...
8
Immunohistochemical characterization of feline lymphoplasmacytic anterior uveitis
... identify. IL-17 was used as a biomarker for Th17 cells; however, it is important to note that a variety of innate immune cells also secrete this cytokine ...as IL-6 and IL- 23 could be used in ...
12