interleukin-4
Gene Expression Profile in Interleukin-4-Stimulated Human Vascular Endothelial Cells
... and interleukin-6 (IL-6), were verified by quantitative real-time reverse transcriptase–polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) ...
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Induction of Interleukin-4 and Interleukin-5 Expression in Mast Cells Is Inhibited by Glucocorticoids
... Cellular inflammation in asthma and other allergic diseases is characterized by the influx of leukocytes, especially eosino- phils. Such inflammation is critical in the airway obstruction in asthma, and secreted products ...
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Rescue and evaluation of a recombinant PRRSV expressing porcine Interleukin 4
... antigens. Interleukin-4 (IL-4) is a pleiotropic cytokine and has been used as an adjuvant to enhance immune response of PRRSV vaccines [23, ...porcine Interleukin-4 (pIL-4) gene ...
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Expression of high affinity interleukin 4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin 4
... Previously, Puri et al. (Puri, R. K., M. Ogata, P. Leland, G. M. Feldman, D. Fitzgerald, and I. Pastan. 1991. Cancer Res. 51:3011-3017) have demonstrated that murine sarcoma and colon adenocarcinoma cells express high ...
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Oligoclonal bands and levels of interleukin 4, interleukin 10, and tumor necrosis factor alpha in idiopathic intracranial hypertension Egyptian patients
... it may also show a fluctuating course with “remission and relapses” like that seen in autoimmune disorders. How- ever, the exact pathophysiology of it is still not clear [8, 9]. Interleukin-4, IL-10, and ...
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Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
... In addition to driving the differentiation of T H 0 lymphocytes into the T H 2 phenotype, IL-4 is important in allergic immune responses owing to its ability to prevent apoptosis of T lym- phocytes. Activation of ...
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Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4
... Intracerebroventricular (icv) injections were made as previously described [17]. Briefly, mice were deeply anes- thetized with a subcutaneous injection of a mixture of keta- mine and xylazine (78 and 6 mg/kg, ...
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Anti interleukin 13 and anti interleukin 4 agents versus placebo, anti interleukin 5 or anti immunoglobulin E agents, for children and adults with asthma
... cytokines interleukin-4, -5, and -13 play a central role in the pathophysiology (de Groot ...targeting interleukin-4, -5, and -13, have been developed; the evidence around ...
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Signaling Pathways Activated by Interleukin-2 and Interleukin-4 Receptors Mediate T Lymphocyte Clonal Expansion
... cytokines interleukin-2 (IL-2) and interleukin-4 (IL-4) are key regulators of the adaptive immune system, particularly influencing the clonal expansion and differentiation of T ...
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Interleukin-4 Receptor Expression on AIDS-Associated Kaposi’s Sarcoma Cells and Their Targeting by a Chimeric Protein Comprised of Circularly Permuted Interleukin-4 and Pseudomonas Exotoxin
... Obiri NI, Hillman GG, Haas GP, Sudha S, Puri RK (1993) Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitr[r] ...
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Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4 stimulated human lymphocytes
... immunoglobulin E (IgE) by interleukin 4 (IL-4)-stimulated human lymphocytes. The effect is glucocorticoid specific and is obtained with low concentrations of HC (0.1-10 microM). In both the early and ...
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Intracellular Signaling Networks in the Immune Response: Pathways Activated by Interleukin-2 and Interleukin-4 Receptors and their Roles in T Cell Proliferation
... cytokines interleukin-2 (IL-2) and interleukin-4 (IL-4) are key regulators of the adaptive immune system, particularly influencing the clonal expansion and differentiation of T ...
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Effect of Eight Week Endurance Training on Serum Levels of Interleukin-2 and Interleukin-4 in Sedentary Men
... ABSTRACT: One of the factors that affect the immune system status and function is Physical activity. To find the response of cytokines to exercise, we examined the possible effects of an 8-week endurance training program ...
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Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study
... IL-4 is a Th2 cytokine that plays an essential role in IgE regulation. It triggers isotype switching from IgM to IgE, induces differentiation to Th2 phenotype on T cells and plays a critical role in the induction ...
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Role of interleukin 4 in regulation of age related inflammatory changes in the hippocampus
... One of the arguments advanced to support the idea that increased hippocampal concentration of IL-1  contributes to the age-related deficit in LTP is that IL-1  treatment also inhibits LTP (7); if a decrease in ...
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Interleukin-17-producing decidual CD4+ T cells are not deleterious for human pregnancy when they also produce interleukin-4
... On the basis of the cytokines produced, the human effector CD4+ T helper cells have been classified as T helper (Th)1, (Th)2 and, more recently, as (Th17) cells [3, 4]. Indeed, CD4+ Th1 cells, which produce ...
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Interleukin-4 and 13 concentrations in infants at risk to develop Bronchopulmonary Dysplasia
... The recombinant human cytokines IL-4 and IL-13, mono- clonal and biotinylated monoclonal antibodies to IL-4 and IL-13 were purchased from Endogen (Woburn, MA). Streptavidin-horseradish peroxidase ...
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Interleukin 4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells
... formation by CMMoL cells. On the other hand, none of anti-IL-1-beta, anti-granulocyte-CSF, anti-macrophage-CSF, or anti-tumor necrosis factor-alpha antibodies affected the CMMoL colony formation. In the supernatants from ...
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The involvement of interleukin 1 and interleukin 4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration
... In conclusion, this study has investigated the involve- ment of the cytokines IL-1 and IL-4 in the mechano- transduction pathways of human AF cells derived from nondegenerative and degenerative tissue following ...
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Azbil, Tatiana (2006): Nachweis von Candida-Spezies und Bestimmung der Zytokine Interleukin-1 beta, Interleukin-1ra, Interleukin-4, Interleukin-6, Interleukin-8, Interleukin-10 und Interleukin-12 im Vaginalsekret und im Serum bei Schwangeren in Relation zum Gestationsalter. Dissertation, LMU München: Medizinische Fakultät
... Studiendesign: Diese prospektive longitudinale Beobachtungsstudie wurde in der Klinik und Poliklinik für Geburtshilfe und Frauenheilkunde des Universitätsklinikum Großhadern von März 2002 bis Oktober 2004 durchgeführt. ...
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