Interleukin 4 (IL4)
Anti interleukin 13 and anti interleukin 4 agents versus placebo, anti interleukin 5 or anti immunoglobulin E agents, for children and adults with asthma
... cytokines interleukin-4, -5, and -13 play a central role in the pathophysiology (de Groot ...targeting interleukin-4, -5, and -13, have been developed; the evidence around ...
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Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
... In addition to driving the differentiation of T H 0 lymphocytes into the T H 2 phenotype, IL-4 is important in allergic immune responses owing to its ability to prevent apoptosis of T lym- phocytes. Activation of ...
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Induction of Interleukin-4 and Interleukin-5 Expression in Mast Cells Is Inhibited by Glucocorticoids
... Cellular inflammation in asthma and other allergic diseases is characterized by the influx of leukocytes, especially eosino- phils. Such inflammation is critical in the airway obstruction in asthma, and secreted products ...
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Interleukin 4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3 dependent eosinophilia
... Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopa- thology. Mechanisms of eosinophilia in non-mucosal tissues during infection remain unre- solved. Here we identify a pivotal ...
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Expression of high affinity interleukin 4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin 4
... Previously, Puri et al. (Puri, R. K., M. Ogata, P. Leland, G. M. Feldman, D. Fitzgerald, and I. Pastan. 1991. Cancer Res. 51:3011-3017) have demonstrated that murine sarcoma and colon adenocarcinoma cells express high ...
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Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women.
... Interleukin-4 (IL-4), IL-6, and IL-10 produced by T-helper 2 (Th2) cells plays an important role in the inhibition of cellular immunity and induction of placental growth (Gratacs et al., 1998; ...
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Roles of interferon gamma and interleukin 4 in murine lupus
... of IL4-Fas1 sera did test positive by FANA compared with IL4 1 Fas 1 counterparts (64 versus 20%; P , ...of IL4-lpr sera contained high-titer antinu- clear antibodies compared with IL41lpr ...
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Effects of Interleukin-4 or Interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis
... adenovirus-5 was therapeutic for acute TNBS-induced rat colitis, which was associated with an inhibition of indu- cible nitric oxide expression and a reduction in nitric oxide synthesis. However, the acute DSS-induced ...
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Interleukin-1 Receptor Antagonist ( IL1RA ) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects
... of IL4 VNTR can be ...The IL4 VNTR is considered a rare genetic polymorphism, as the MAF was ...that IL4 VNTR is highly influenced by ethnicity [reviewed in ...with IL4, the allele and ...
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Interleukin-4 (IL4) and Interleukin-4 receptor (IL4RA) polymorphisms in asthma: a case control study
... that IL4 polymorphisms are associated with total IgE levels and potentially with asthma and other allergy related phenotypes has been provided, although ethnical differences have been reported ...of IL4 has ...
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Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4.
... IL-2/4-deficient mice showed greater variability in their im- mune responses than control mice did. This variability in im- mune response may be explained by the fact that these mice are variably susceptible to a ...
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Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer
... IFNGR: Interferon gamma receptor; IFNα: Interferon alpha; IFNβ: Interferon beta; IFNγ: Interferon gamma; IL10: Interleukin-10; IL13: Interleukin-13; IL4: Interleukin-4; IRAK: Interleukin[r] ...
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Signaling Pathways Activated by Interleukin-2 and Interleukin-4 Receptors Mediate T Lymphocyte Clonal Expansion
... Interleukin-2 is a 15.5 kDa pleiotropic cytokine, secreted by activated T cells, that plays an immensely important role in activating the adaptive immune system; due to its capability of serving as both an ...
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Recombinant interleukin 12 suppresses the synthesis of immunoglobulin E by interleukin 4 stimulated human lymphocytes
... gamma, a known inhibitor of IgE synthesis and (b) by a novel mechanism which is IFN- gamma independent. The best evidence for this is from studies on IgE synthesis by IL-4- plus hydrocortisone-stimulated umbilical ...
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Changes in interleukin 2 and interleukin 4 production in asymptomatic, human immunodeficiency virus seropositive individuals
... IL- 4 generated by PBL from HIV-seropositive (HIV+) individuals who did not have AIDS, yet who exhibited different TH functional categories based on their IL-2 production ...
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... as interleukin 1 (IL-1), IL-6, IL-18 and tumor necrosis factor-α (TNFα) have been linked to the development and progression of ...between interleukin-4 (IL4) -590C/T (rs2243250) gene ...
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Assessment of Pro-Inflammatory Cytokines Level in Stored Blood for Transfusion in Port Harcourt, Nigeria
... trend of accumulation of the interleukins of focus (i.e. IL-4, IL-6, and TNF-α). The Elabscience Biotechnology Company Ltd (ELISA, USA) kit, specifically designed for the analysis of IL-4, IL-6, and TNF-α ...
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The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects
... Interleukin-4 a definer of Th-2 subset exerting dominant anti proliferative effects is identified among the critical cyto- kines promoting HIV immunopathology [15]. However, with HAART commencement, ...
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Simvastatin nanoparticles attenuated intestinal ischemia/reperfusion injury by downregulating BMP4/COX-2 pathway in rats
... protein 4 (BMP4)/cyclooxygenase-2 (COX-2) pathway as compared to free simvastatin ...of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis ...
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Increased CD4+ T cell lineage commitment determined by CpG methylation correlates with better prognosis in urinary bladder cancer patients
... Urinary bladder cancer (UBC) is the ninth most frequent cancer disease with 380,000 new cases diagnosed worldwide and about 150,000 deaths yearly [1, 2]. Environmental factors and life style seem to play an important ...
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