Interleukin 6
The involvement of proinflammatory cytokines in diabetic nephropathy: Focus on interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α) signaling mechanism
... About 20-40% of type 2 diabetic patients may develop diabetic nephropathy (DN) as its complication. The pathogenesis of DN is complex. Classically, metabolic and hemodynamic impairment are considered as its pathogenesis. ...
8
Targeting interleukin-6 for noninfectious uveitis
... Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious ...Keywords: ...
6
The ubiquitous interleukin-6: a time for reappraisal
... Interleukin-6 (IL-6) is a multifunctional cytokine regulating humoral and cellular responses and playing a central role in inflammation and tissue injury. Its effects are mediated through interaction ...
6
Targeting interleukin-6 in rheumatoid arthritis
... lack head-to-head success in regards to superiority of the biologics given as monotherapy against methotrexate [3-5]. Even when a TNF-inhibitor is given in combination with DMARDs, the rate of inadequate response has ...
47
The efficacy and safety of anti-interleukin-6 receptor monoclonal blockade in a renal transplant patient with Castleman disease: early post-transplant outcome
... Background: Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disease characterized by systemic inflammatory reactions associated with the dysregulated production of interleukin-6 ...
5
Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin 6 as a Potential Susceptibility Locus
... In this report, we used a bioinformatic strategy to identify polymorphisms that may account for the increased risk of blastomycosis among the WI Hmong and functionally validated our findings with in vitro studies of human ...
12
Interleukin 6 and rheumatic diseases
... Genetically manipulated mice have been useful in identifying the role of specific cytokines in models of human disease. In most circumstances, ablation of a single cytokine is compatible with normal life [7], affording ...
5
Interleukin 6 and chronic inflammation
... IL-6 elicits not only acute phase reactions but also the development of specific cellular and humoral immune responses, including end-stage B cell differentiation, immunoglobulin secretion and T cell activation. ...
6
Reactive Hyperemia and Interleukin 6, Interleukin 8, and Tumor Necrosis Factor-α in the Diagnosis of Early-Onset Neonatal Sepsis
... The ideal cutoff point for IL-6, IL-8, and TNF-␣ serum concentrations is the point that allows detec- tion of as many true-positive findings as possible (high sensitivity) and with few false-positive results (high ...
8
Kaposi's Sarcoma Associated Herpesvirus Interleukin 6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration
... vIL-6 and elevated hIL-6 are detectable in all KSHV-associated malignancies (14, 61–63), and these two cytokines likely work in a synergistic manner to create a proinflammatory environment that promotes ...
12
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes
... IL6 gene plays an important role in the regulation of sys- temic inflammatory pathways. Some common single nu- cleotide polymorphisms (SNPs), including IL6 -572G > C and IL6 -174G > C have been shown to influence ...
11
ZNF580 – a brake on Interleukin-6
... Specific primers used for amplification of ZNF580, glyc- eraldehyde 3-phosphate dehydrogenase (GAPDH) and IL-6 are shown in table 1and were purchased from Euro- fins, Hamburg, Germany. Real-time PCR was performed ...
10
Association of 174 G>C interleukin 6 gene polymorphism with interleukin 6 and c reactive protein levels and obesity: A case–control study among people/residents of Western Indonesia
... In the obese group in this study, the C carriers had lower levels of IL-6, but higher levels of CRP than G carriers. These results were consistent with the role of IL-6 as an anti- inflammatory, ...
5
Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia.
... Previous investigations have tested the association between IL-10 gene polymorphisms and preeclampsia development, but with conflicting results (Stonek et al., 2008; Vural et al., 2010; Valencia Villalvazo et al., 2012; ...
8
The effect of glycogen depletion on responses of interleukin-1beta, interleukin-6, and interleukin-10 to maximal exercise
... result of intensity/duration manipulation must linger into recovery. As mentioned in the opening of this chapter, IL-1β and IL-6 are known to stimulate the adrenal pituitary axis to ultimately cause cortisol ...
55
Interleukin 6: discovery of a pleiotropic cytokine
... receptor system has an unusual organization. It consists of two polypeptide chains [21]: an 80 kDa IL-6 receptor and a 130 kDa signal transducer (gp130). The 80 kDa receptor exists in two forms, namely the ...
6
Immunotherapy of brain metastases: breaking a “dogma”
... IL: Interleukin; IL-10: Interleukin-10; IL-1 β : Interleukin-1 β ; IL- 23: Interleukin-23; IL-6: Interleukin-6; IL-8: Interleukin-8; Ir: Immune-related; iRANO: ...
10
Original Article Effects of glutamine on alveolar epithelial barrier function after cardiopulmonary bypass
... (RI), interleukin-6 (IL-6), interleukin-10 (IL-10), tumornecrosisfactor-α (TNF-α), lipopolysaccharide (LPS), matrix metalloprotein-9 (MMP-9), extravascular lung water (EVLW), malonic ...
11
Toll like receptors in the endangered Tasmanian devil and devil facial tumour disease
... cytokines interleukin-1α (IL1α), interleukin- 6 (IL6), interleukin-12A (IL12A) and interferon-β (IFNβ), and the costimulatory molecule ...
314
Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus
... that interleukin-1 beta (IL-1β) could initiate and aggravate seizure activity in epileptic experimental animal models [11, ...IL- 6 protein showed a transient increase in glial cells which was prominent ...
11