Interleukin (IL)-6
Targeting interleukin-6 for noninfectious uveitis
... Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious ...Keywords: ...
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The involvement of proinflammatory cytokines in diabetic nephropathy: Focus on interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α) signaling mechanism
... About 20-40% of type 2 diabetic patients may develop diabetic nephropathy (DN) as its complication. The pathogenesis of DN is complex. Classically, metabolic and hemodynamic impairment are considered as its pathogenesis. ...
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The ubiquitous interleukin-6: a time for reappraisal
... Interleukin-6 (IL-6) is a multifunctional cytokine regulating humoral and cellular responses and playing a central role in inflammation and tissue injury. Its effects are mediated through interaction ...
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Targeting interleukin-6 in rheumatoid arthritis
... lack head-to-head success in regards to superiority of the biologics given as monotherapy against methotrexate [3-5]. Even when a TNF-inhibitor is given in combination with DMARDs, the rate of inadequate response has ...
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Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin 6 as a Potential Susceptibility Locus
... In this report, we used a bioinformatic strategy to identify polymorphisms that may account for the increased risk of blastomycosis among the WI Hmong and functionally validated our findings with in vitro studies of human ...
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The efficacy and safety of anti-interleukin-6 receptor monoclonal blockade in a renal transplant patient with Castleman disease: early post-transplant outcome
... Background: Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disease characterized by systemic inflammatory reactions associated with the dysregulated production of interleukin-6 ...
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Reactive Hyperemia and Interleukin 6, Interleukin 8, and Tumor Necrosis Factor-α in the Diagnosis of Early-Onset Neonatal Sepsis
... Blood samples for cytokine and CRP determinations were cen- trifuged within 30 minutes of collection, and sera were transferred to plastic tubes. Sera then were stored at ⫺70°C pending simul- taneous assay at the end of ...
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Kaposi's Sarcoma Associated Herpesvirus Interleukin 6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration
... vIL-6 and elevated hIL-6 are detectable in all KSHV-associated malignancies (14, 61–63), and these two cytokines likely work in a synergistic manner to create a proinflammatory environment that promotes ...
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Interleukin 6 and rheumatic diseases
... Apart from controlling the signs and symptoms of inflam- matory arthritis, blockade of IL-6R signalling also exerted a positive effect on a number of other manifestations of these conditions. For example, in chronic ...
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Association of 174 G>C interleukin 6 gene polymorphism with interleukin 6 and c reactive protein levels and obesity: A case–control study among people/residents of Western Indonesia
... In the obese group in this study, the C carriers had lower levels of IL-6, but higher levels of CRP than G carriers. These results were consistent with the role of IL-6 as an anti- inflammatory, ...
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ZNF580 – a brake on Interleukin-6
... Specific primers used for amplification of ZNF580, glyc- eraldehyde 3-phosphate dehydrogenase (GAPDH) and IL-6 are shown in table 1and were purchased from Euro- fins, Hamburg, Germany. Real-time PCR was performed ...
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A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes
... To our knowledge, this is the first evidence on gene- air pollution interaction in adult diabetes. Until now, gene-air pollution interaction studies focused on respira- tory and cardiovascular outcomes, exploring diverse ...
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Interleukin 6 and chronic inflammation
... [22,23] (Figure 2). IL-6 signalling through sIL-6R α controls leucocyte infiltration. In vitro studies confirm that sIL-6R α mediated events regulate both chemokine and adhesion molecule expression. As a result, ...
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Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia.
... habitual abortion or complications of pregnancy may result (Kamali-Sarvestani et al., 2005; Choi and Kwak-Kim, 2008). IL-10 is a Th2 cytokine able to promote placental cell growth and differentiation, inhibit lymphocyte ...
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The effect of glycogen depletion on responses of interleukin-1beta, interleukin-6, and interleukin-10 to maximal exercise
... greatest stimulus may have been in the last few stages when intensity was highest. This is similar to how catecholamines respond to progressive exercise, in comparison to steady-state exercise, as they work to make more ...
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Interleukin 6: discovery of a pleiotropic cytokine
... cloned and found to be identical to B cell stimulatory factor-2. Later, a hybridoma/plasmacytoma growth factor and a hepatocyte stimulating factor were also proven to be the same molecule as B cell stimulatory factor-2. ...
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Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus
... that interleukin-1 beta (IL-1β) could initiate and aggravate seizure activity in epileptic experimental animal models [11, ...IL- 6 protein showed a transient increase in glial cells which was prominent ...
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Immunotherapy of brain metastases: breaking a “dogma”
... IL: Interleukin; IL-10: Interleukin-10; IL-1 β : Interleukin-1 β ; IL- 23: Interleukin-23; IL-6: Interleukin-6; IL-8: Interleukin-8; Ir: Immune-related; iRANO: ...
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Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury
... cytokines interleukin-1 β (IL-1 β ) and interleukin-6 (IL-6) and degrading enzyme matrix metalloproteinase 13 (MMP-13), all indicative of cartilage degeneration and osteoarthritis development ...
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Original Article Effects of glutamine on alveolar epithelial barrier function after cardiopulmonary bypass
... (RI), interleukin-6 (IL-6), interleukin-10 (IL-10), tumornecrosisfactor-α (TNF-α), lipopolysaccharide (LPS), matrix metalloprotein-9 (MMP-9), extravascular lung water (EVLW), malonic ...
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