intestinal tumor
Chemopreventive effects of berberine on intestinal tumor development in Apc min/+mice
... Dysregulation of Wnt signaling pathway has been re- ported to play a major role in intestinal tumorigenesis in humans and Apc min/+ mice [10,14,28]. Truncated APC protein encoded by mutated gene causes cytoplasmic ...
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SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling
... during intestinal tumorigenesis, SOX9 expression is maintained in response to the constitutive activation of the Wnt/ß-catenin signaling pathway [1] and that the occurrence of several events (mutations, MiniSOX9 ...
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A pitfall of bilateral inferior petrosal sinus sampling in cyclic Cushing’s syndrome
... endocrine intestinal tumor of unknown primary, in whom a BIPSS performed during a trough phase was wrongly suggestive of central ACTH ...a tumor, which is cyclically the source of ACTH ...
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Cancer Stem Cell Markers CD44, CD133 in Primary Gastric Adenocarcinoma
... (intestinal), tumor size (4-8 cm), depth of invasion, no lymphatic/vascular invasion and moderate ...(intestinal), tumor size (4-8 cm), depth of invasion and moderate ...
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SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development
... The somatic E76G mutation specifically found in colorectal cancer specimens disrupts the inhibitory intramolecular interaction within the PTP domain and leads to the hyperactivation of SHP-2 [40]. Given the latter, we ...
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Tumor specific apoptosis caused by deletion of the ERBB3 pseudo kinase in mouse intestinal epithelium
... malignant intestinal epithelium have not been ...the intestinal epithelium of mice with intestine- specific genetic ablation of Erbb3 exhibits no cytological abnormalities but does exhibit loss of ...
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Jiang, Longchang (2017): Genetic analysis of miR-34a and miR-34b/c functions in a mouse model of familial adenomatous polyposis. Dissertation, LMU München: Medizinische Fakultät
... during intestinal tumorigenesis ...increased tumor organoid formation rate in miR- 34a/b/c -/- ; Apc Min/+ adenomas as well as an increased accumulation of nuclear ...
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Mebendazole and a non-steroidal anti-inflammatory combine to reduce tumor initiation in a colon cancer preclinical model
... Nonsteroidal anti-inflammatory drugs (NSAIDs), such as sulindac, represent an effective class of compounds for the prevention of colon cancer [16, 17], and a logical starting point for more effective chemo-preventative ...
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Sphingosine kinase 1 expression enhances colon tumor growth
... large intestinal tumors were noted grossly for their location, number and ...each tumor were meas- ured with calipers and tumor volume (V) was calculated using the formula V = L∙W∙D∙π/6 ...of ...
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ABSTRACTS
... We have now demonstrated that the cell surface membranes of human fetal intestinal cells, rat intestinal tumor cells, and normal mitotically active rat intestinal crypt cells appear to h[r] ...
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p120 Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia
... Interestingly, this theme of codependence extends also to obligate haploinsufficiency. Indeed, α-catenin and E-cadherin are known to be haploinsufficient tumor suppressors from pre- vious KO studies in mice (58, ...
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Case Report Malignant small intestinal stromal tumor combined with thoracic intraspinal and posterior mediastinal tumor in a patient with neurofibromatosis-1
... chance, and the patients usually present with gastrointestinal bleeding, which is often chron- ic or intermittent. In addition, they are often found in patients with anemia, constipation or obstruction. The current ...
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Inhibition of CXCR2 profoundly suppresses inflammation driven and spontaneous tumorigenesis
... primary tumor formation, the functional redundancy built into the che- mokine system to ensure robust responses during infection will limit the effect that any single chemokine receptor will have on de novo ...
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Tumor Suppressor Gene p53 status in Upper Gastro Intestinal Malignancies
... ESCC tumor tissues and in other normal looking ...natural tumor cells when they exposed the non-tumor esophageal mutant p53 expressing cells to genotoxic ...
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Peripheral Primitive Neuroectodermal Tumor of Small Bowel Mesentry Presenting as Intestinal Obstruction: A Case Report.
... ovarian tumor and an erect X-ray abdomen ...nodular tumor measuring 10x8x6 cm was seen arising from the mesenteric border of the ...for tumor. resection of the tumor along with segmental ...
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Anti cervical carcinoma effect of Portulaca oleracea L polysaccharides by oral administration on intestinal dendritic cells
... for tumor cells from the immune surveillance sys- ...from intestinal mucosa are more potent in stimulating allogeneic T-cells proliferation rather than DC from spleen ...the intestinal immune system ...
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Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report
... Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report Andrea Marino* ,[r] ...
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Intestinal Hyperplasia Induced by Simian Virus 40 Large Tumor Antigen Requires E2F2
... in intestinal hyperplasia, and that the induction of enterocyte proliferation requires T-antigen binding to Rb ...T-antigen-induced intestinal proliferation is reduced in mice lacking either E2F2 alone or ...
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The role of Hes genes in intestinal development, homeostasis and tumor formation
... the intestinal crypt, and that it represses the expression of the Math1 (Atoh1) and neurogenin 3 (Ngn3 or Neurog3) genes (Jensen et ...of intestinal stem/progenitor cells and inhibits secretory cell ...
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Multiple lesions of gastrointestinal tract invasion by monomorphic epitheliotropic intestinal T-cell lymphoma, accompanied by duodenal and intestinal enteropathy-like lesions and microscopic lymphocytic proctocolitis: a case series
... Microscopic colitis consists of lymphocytic and collag- enous colitis with >20 IELs per 100 surface epithelial cells and no or little architectural distortion of the crypts [10]. While of uncertain etiology, both ...
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