intimal hyperplasia
Analysis of arterial intimal hyperplasia: review and hypothesis
... of intimal hyperplasia, are traditionally founded on the cornerstone question: what causes the pathology? I argue that this question is misplaced because it implies that (a) intimal ...
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Original Article External stents inhibit intimal hyperplasia of rabbit autologous vein grafts via modulation of matrix metalloproteinase-2 expression
... in intimal hyperplasia of vein grafts, exploring its underlying mecha- ...mitigated intimal hyperplasia (P < ...the intimal hyperplasia of vein ...
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Antibodies against transforming growth factor beta 1 suppress intimal hyperplasia in a rat model
... neointimal lesions, but were almost completely absent from the lesions of the anti-TGF-beta 1-treated animals. We conclude that TGF-beta 1 is causally involved in the development of intimal hyperplasia, and ...
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PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a
... Activation of vascular SMC proliferation is a key event in the devel- opment of atherosclerosis and its complications (1). In response to vascular injury, SMCs migrate from the media into the intimal layer of the ...
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The viral anti inflammatory chemokine binding protein M T7 reduces intimal hyperplasia after vascular injury
... The attraction of inflammatory cells to damaged or infected tissues is essential for the host responses to injury and infection. The inflammatory cell response process is controlled by chemokines, chemotactic cytokines ...
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Recombinant platelet derived growth factor B gene expression in porcine arteries induce intimal hyperplasia in vivo
... in intimal to medial ratio was present in PDGF B gene transfected arteries compared with control transfected arteries (P = ...of intimal hyperplasia, which can lead to cardiovascular ...
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Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries
... Basic fibroblast growth factor (bFGF) is mitogenic for smooth muscle cells (SMC) and angiogenic. We examined the in vivo effects of bFGF in balloon denuded carotid arteries of laboratory rats. bFGF was administered ...
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Exosomes derived from human umbilical cord mesenchymal stem cells inhibit vein graft intimal hyperplasia and accelerate reendothelialization by enhancing endothelial function
... membrane dye labelling proved that hucMSC-exosomes can be assimilated into HUVECs. This is similar to the report showing the incorporation of exosomes secreted by adipose-derived MSCs into HUVECs [41]. As it is known ...
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Effects of fenofibrate on lipid profiles, cholesterol ester transfer activity, and in-stent intimal hyperplasia in patients after elective coronary stenting
... neointimal hyperplasia after coronary stenting in a porcine model ...inhibits intimal hyperplasia by inhibiting vascular cell recruitment and smooth muscle cell proliferation ...stent intimal ...
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Cathepsin L Promotes Vascular Intimal Hyperplasia after Arterial Injury
... Figure 1. Cathepsin L drives intimal hyperplasia and macrophage infiltration. (A) Arterial enzyme activity for cathepsin L was measured by a fluorescence-based assay and normalized to tissue extract protein ...
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Accelerated intimal hyperplasia in aortocoronary internal mammary vein grafts in minipigs
... The saphenous vein is still a conduit of choice for coro- nary artery bypass grafting. Following arterializations, vein grafts undergo immediate injury like ischemia and wall stress. The histological changes associated ...
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Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
... intima hyperplasia, platelet- derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) are important regulators of VSMC behavior through their well-defined respective actions as a potent chemoattrac- ...
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The expression and function of G proteins in experimental intimal hyperplasia
... G-proteins are membrane-bound signal transduction proteins which couple extracellular receptor signals to various effectors. This study examines the expression and the function of G-proteins (alpha i, alpha s, alpha q, ...
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INtimal hyPerplasia evAluated by oCT in de novo COROnary lesions treated by drug eluting balloon and bare metal stent (IN PACT CORO): study protocol for a randomized controlled trial
... neointimal hyperplasia after BMS implantation (primary endpoint of this study) and acute coronary syndromes may influence acute stent apposition to the vessel wall (one of the sec- ondary endpoints), we decided to ...
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Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model
... We have used antisense phosphorothioate oligonucleotides to define the role played by proliferating cell nuclear antigen PCNA in neointimal accumulation of smooth muscle cells in a rat c[r] ...
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Nitrite generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague Dawley rats
... neointimal hyperplasia, which is marked by uncontrolled SMC ...neointimal hyperplasia is potentiated secondary to limited availability of the NO synthase substrate arginine, leading to diminished produc- ...
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Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides
... activated after vascular injury, we administered the combination of antisense cdc 2 and cdk 2 ODN in this study. Antisense cdc 2 ODN alone (15 microM) only reduced intimal formation by 40%. Combined antisense ...
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Coronary artery bypass grafting hemodynamics and anastomosis design: a biomedical engineering review
... anastomotic intimal hyperplasia; DOS: Distal outlet segment; EC: Endothelial cell; ETE: End-to-end; ETS: End-to-side; HP: Hemodynamic parameter; IH: Intimal Hyperplasia; IMA: Internal mammary ...
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Transauricular balloon angioplasty in rabbit thoracic aorta: a novel model of experimental restenosis
... Methods: Twenty male New Zealand rabbits were randomly divided into two groups of ten animals, as follows: atherogenic diet plus balloon angioplasty (group A) and atherogenic diet alone (group B). Β alloon angioplasty ...
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Histopathologic changes of the radial artery wall secondary to transradial catheterization
... injured by the introducer sheath when compared to arteries that were never injured. The same findings were observed when the distal ends of the arteries were compared with the more proximal ends, supporting the concept ...
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