intracellular ATP
Modulation of intracellular ATP influences seizure activity via the activity dependent release of adenosine
... Figure 5.1. Basal neuronal activity was unaffected by manipulations of intracellular ATP. Stepwise stimulation current increases were applied to slices to generate an input/output curve (A; top panel shows ...
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Intracellular ATP can regulate afferent arteriolar tone via ATP sensitive K+ channels in the rabbit
... mM ATP and in a dose-dependent fashion by glibenclamide (10(-9) M to 10(-6) M), a specific antagonist of KATP ...of ATP, and this effect was also blocked by ...whether intracellular ATP levels ...
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Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells
... depletes intracellular aTP and inhibits in vitro capillary-like structure formation in ...of aTP requirement for in vitro tubulogenesis, hBMec were seeded on top of Matrigel as described in the ...
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Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity dependent activation of adenosine A1 receptors
... of intracellular ATP on extracellular adenosine and neuronal excit- ability has been described recently (Kawamura et ...tissue ATP levels with Rib/Ade may be of value in the post- ischemic ...
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ATP generation in a host cell in early phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag
... Results: In this study, we show that the p2 peptide enhances HIV-1 acute infection by increasing intracellular ATP production via the activation of mitochondrial cytochrome c oxidase (MT-CO) involved in the ...
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Akt Activation Protects Liver Cells from Apoptosis in Rats during Acute Cold Exposure
... cellular ATP level, which lasted about one hour. The ATP level went back to basal level after two hours of cold ...cellular ATP depletion and cell apoptosis. The dynamic change of cellular ATP ...
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Less biomass and intracellular glutamate in anodic biofilms lead to efficient electricity generation by microbial fuel cells
... most intracellular metabo- lites related to the tricarboxylic acid cycle and a higher intracellular ATP/ADP ratio, but a lower intracellular NADH/ NAD + ...of intracellular glutamate, ...
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PubMedCentral-PMC5296605.pdf
... require ATP to function, and a drop in ATP will lead to decreased activity, resulting in drug ...lowering intracellular ATP in a growing population to stationary levels with arsenate treatment ...
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Role of adenosine triphosphate (ATP) and NaK ATPase in the inhibition of proximal tubule transport with intracellular cystine loading
... cystinosis. Intracellular ATP was measured using the luciferin-luciferase ...assay. Intracellular ATP was reduced by 60% in proximal convoluted tubules incubated with ...exogenous ATP ...
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Increased concentrations of haemolymph Mg2+ protect intracellular pH and ATP levels during temperature stress and anoxia in the common shrimp
... °C, ATP levels tended to decrease at high and low temperature, but this decrease was only significant at 20 °C ...5A). ATP concentrations and pHi were positively correlated, as shown in ...caused ...
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The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices : evidence for the rapid depletion of cellular ATP during electrographic seizures
... Inclusion of the K + channel blocker 4-AP in the Mg 2+ -free aCSF resulted in the appearance of bursting epileptiform activity (Avoli and Jefferys 2016). This manipulation pro- voked further adenosine release, which was ...
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Biophysical optima for metabolism of Mycobacterium leprae
... Quantitation of intracellular ATP and the rate of [U-14C]palmitic acid incorporation into phenolic glycolipid I PGL-I were used as metabolic indicators after axenic incubation in modifie[r] ...
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Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate
... on intracellular ATP levels and the proliferation rates of prolonged hypoxic cells, we cultured 143B, HeLa, Hep3B and H9c2 cell lines under indicated ...decreased ATP levels in all the four cell ...
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Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress
... the intracellular ATP level and inhibition of the parasite’s V-type H + -ATPase, causing a loss of pH control in both the parasite cytosol and the internal digestive ...
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ATP regulation in bioproduction
... the ATP supply derived from reactions of the respiratory chain ...on ATP generation by sperm ...on ATP generation by the respiratory chain rather than glycolysis, swim faster compared with those from ...
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ADVANCES IN ANTI-TUBERCULOSIS DRUGS
... of ATP synthase, thereby decreasing intracellular ATP levels 32 Bedaquiline was discovered using phenotypic screening An attractive feature of bedaquiline is its equipotent activity against both ...
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Nicorandil-Induced Hyperkalemia in a Uremic Patient
... flow. After activation, they cause intracellular potassium e ffl ux, which in turn results in membrane hyperpolarization, closure of voltage-gated calcium channels, and, ultimately, vasodilation. Besides, they may ...
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Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity
... or intracellular pH variations could contribute to Fluo-4AM fluorescence variations observed in the current ...abrogate ATP-mediated increase in intracellular calcium signal with P2R antagonist ...by ...
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Glycine N-Methyltransferase Deficiency Affects Niemann-Pick Type C2 Protein Stability and Regulates Hepatic Cholesterol Homeostasis
... for ATP-binding cassette A1 (ABCA1), ATP-binding cassette G1 (ABCG1), scavenger receptor class B type 1 (SR-B1), 3-hydroxy-3-methyl-glutaryl- coenzyme A reductase (HMGCR), Niemann-Pick type C1 protein ...
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Theoretical Study on the ATP Hydrolysis Mechanism of HisP Protein, the ATP Binding Subunit of ABC Transporter
... the ATP molecule through hydrogen bonding ...for ATP hydrolysis, interacts with Asp178 through hydrogen ...of ATP hydrolysis, interacts with Gln100 and Glu179 through hydrogen ...by ATP ...
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