intracellular Ca 2+
Original Article Inositol phosphatase INPP4A inhibits the apoptosis of in vitro neurons with characteristic of intractable epilepsy by reducing intracellular Ca 2+ concentration
... Abstract: Epilepsy is a chronic neurological disorder characterized by recurrent seizures. Seizures can be controlled for most epilepsy patients after drug therapy, but at least 20% of patients develop intractable ...
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Phospholipase C inhibits apoptosis of porcine primary granulosa cells cultured in vitro
... lular Ca 2+ ...increase intracellular Ca 2+ [38], which is in line with this study that PLC activator increased the intracellular Ca 2+ con- centration and PLC ...
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The Na+/Ca2+ exchange inhibitor SEA0400 limits intracellular Ca2+ accumulation and improves recovery of ventricular function when added to cardioplegia
... to Ca 2+ influx, hypercontracture, and mitochondrial dam- age is felt to be the primary mechanism responsible for myocardial injury in ischemia-reperfusion ...in intracellular Ca 2+ ...
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Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation
... by Ca +2 “noise” during ...age-associated Ca +2 dysregulation and increases in the ...in intracellular Ca +2 levels that are RyR-dependent ...of Ca +2 , ...
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A review on the effect of sulphur mustard on gene expression alterations, finding the most important molecular functions using gene set functional enrichment analysis
... implicated intracellular Ca 2+ levels in SM toxicity and alterations in Ca 2+ levels are thought to play a role in ...increases intracellular Ca 2+ concentration ...
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β adrenergic receptor/cAMP/PKA signaling contributes to the intracellular Ca2+ release by tentacle extract from the jellyfish Cyanea capillata
... on Ca 2+ influx whilst La 3+ , a non-specific channel and pore blocker, inhibited the Ca 2+ influx, consistent with the presence of a pore- forming toxin existing in the venoms which was ...
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A review of mammalian toxicity of ZnO nanoparticles
... to NP dissolution in medium is still unclear. In vivo airway exposure poses an important hazard. Inhalation or instillation of the NPs results in lung inflammation and systemic toxicity. Reactive oxygen species (ROS) ...
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Polyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue
... monitored intracellular Ca 2+ signals that sensi- tively reflect the activity of both cell ...Astroglial Ca 2+ signals were monitored in the astroglia-rich stratum radiatum area in the ...
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Geranylgeranyl acetone prevents glutamate-induced cell death in HT-22 cells by increasing mitochondrial membrane potential
... Geranylgeranyl acetone (GGA) protects against various types of cell damages by upregulating heat shock proteins. We investigated whether GGA protect neuronal cells from cell death induced by oxidative stress. Glutamate ...
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Mechanisms of anthracycline induced dysfunction of ca2+ handling proteins in the heart
... Several proteins important in intracellular Ca 2+ signalling have been identified as drug binding targets, including the cardiac ryanodine receptor Ca2+ release channel RyR2, the Ca2+ bi[r] ...
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CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca2+ channels upstream of p38 MAPK
... of intracellular Ca 2+ in cerebrocortical neurons ...cellular Ca 2+ resulting in intracellular Ca 2+ overload, downstream activation of p38 MAPK and p53, release of ...
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Extremely low frequency electromagnetic fields promote mesenchymal stem cell migration by increasing intracellular Ca2+ and activating the FAK/Rho GTPases signaling pathways in vitro
... addition, intracellular Ca 2+ levels are implicated in the disassembly of adhesions at the ...for intracellular Ca 2+ are the calcium- regulated phosphatase calcineurin and the ...
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Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
... performed intracellular Ca 2+ imaging experi- ments to determine the effects of 300 μg/ml SiNPs on the response of TRPV1 to its specific agonist capsaicin (1 ...
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Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes
... of Ca 2+ signaling from mitochondria in the regulation of cell ...of intracellular Ca 2+ homeostasis due to ATP depletion and release of Ca 2+ ions from the mitochon- dria ...
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TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition
... The difference between TRO40303 and classic TSPO ligands such as PK11195, chlorodiazepam, or SSR180575 is that TRO40303 binds to the cholesterol site and is potentially a substrate of TSPO, whereas classic TSPO ligands ...
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Calcium homeostasis in rat sympathetic neurones: A primary role for the plasma membrane calcium ATPase
... the Ca^^ current pulse (see figu res 17 and ...averaged Ca^^ transients and therefore the delay observed between the peak o f the Ca^^ current and the peak o f the Ca^^ transient might reflect ...
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Ca(2+)-dependent regulation of the Ca(2+) concentration in the myometrium mitochondria. I. Trifluoperazine effects on mitochondria membranes polarization and [Ca(2+)](m)
... fluorimeter (Photon Technology International) and the fluorescent probe Fluo 4AM (λ exc = 490 nm, λ em = 520 nm). Myometrium mitochondria were loaded with 2 µM Fluo 4AM for 30 min at 37 °C in a medium with ...
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The Calcineurin Pathway Inhibitor Tacrolimus Enhances the In Vitro Activity of Azoles against Mucorales via Apoptosis
... Azoles (PCZ, ICZ) in combination with TCR induce mor- phological changes of apoptosis in R. oryzae, C. bertholletiae, and M. circinelloides. Our results with mitochondrial damage, ROS accumulation, and Ca ...
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Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice
... KRBH containing 2.8 mM glucose. Islets were then divided into groups and stimulated with different com- pounds as indicated in the results section, for one hour. Control group was maintained in basal glucose. Each group ...
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The inhibitory influence of calix[4]arene of C-90 on the activity of Ca(2+),Mg(2+)-ATPases in plasma membrane and sarcoplasmic reticulum in myometrium сells
... confocal microscopy. The SMC suspension (100 µl) was immobilized on a microscope slide treated with poly‑L‑lysine (200 µl) for 2 h at 25 °C. Unattached myocytes were washed with solution B ((mM): 136.9 NaCl, 5.36 ...
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