Intracellular Signaling
Vertical nanowire probes for intracellular signaling of living cells
... for intracellular probing of the electrical activity of single ...an intracellular mode, can be successfully achieved by controlling the diameter, length, and density of the ...that intracellular ...
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Intracellular Signaling by the comRS System in Streptococcus mutans Genetic Competence
... intercellular signaling role for XIP includes the detection by LC-MS/MS of XIP in supernates of ...competence signaling when autolysis releases sufficient concentrations of ComS or ...an intracellular ...
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Atrial specific pathways for control of intracellular signaling and myocyte function
... over intracellular signaling, and defects in local signaling are commonly linked to decreased function and arrhyth- mia in cardiac ...ant signaling domains, most notably the cardiac dyad ...
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The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration
... Research over the past decade has greatly expanded our un- derstanding of the PHR proteins on numerous fronts. 1) Mounting evidence indicates that PHR proteins both posi- tively and negatively regulate multiple ...
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Intracellular Signaling by the Chemokine Receptor US28 during Human Cytomegalovirus Infection
... specific intracellular pathways in response to CC chemokine stimulation, we confirmed that endogenous human CC chemokine receptors were not ex- pressed during CMV ...activate intracellular signaling ...
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Intracellular signaling pathways of ErbB2/HER 2 and family members
... lum, leading to its functional inactivation [19], has proven a useful tool to address this question in more detail. Inducible expression of this single-chain antibody in the ErbB2 over- expressing breast carcinoma cell ...
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Applications of Quantitative Live-cell Microscopy to Study Intracellular Signaling Dynamics.
... the signaling pattern might be related to local changes in cell ...call signaling vector analysis ...PI3K signaling were identified, tracked, and related to the morphodynamics of the cells as they ...
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Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling
... The precise role of erythropoietin receptor–activated (EpoR-activated) Stat5 in the regulation of erythropoiesis remains unclear. In this issue of the JCI, Menon and colleagues present new experimental data that indicate ...
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Intracellular Signaling Mechanisms and Activities of Human Herpesvirus 8 Interleukin-6
... hexameric signaling complex ...tetrameric signaling complexes are induced by vIL-6 in the ER compartment and that only vIL-6 and not hIL-6 can activate gp130 in ...for intracellular retention in ...
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Endothelial activation: intracellular signaling pathways
... its signaling, a series of zinc fingers, and C-terminal TRAF domains shared with other members of the TRAF ...AP-1 signaling independent of TNF, TNFR1, or TRADD, possibly by driving association of adaptor ...
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Sneaking ligands inhibiting NF-kappaB activation selectively in endothelial cells improve experimental arthritides
... and signaling molecules for the development of innovative targeted therapies are ...of intracellular signaling pathways that bases on multi-modular structured recombinant fusion ...
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Adapters in lymphocyte signaling
... Most likely, these phosphorylation patterns are regu- lated not only by the quality of the antigen binding to the immunoreceptor, but also by signals that are trans- mitted via accessory receptors. The ligands for these ...
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Neuroinflammation in Alzheimer’s disease
... MAPK signaling pathways. Both these signaling pathways are associated with the transcrip- tion of inflammatory mediators (see the section “Intracellular signaling ...
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Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models
... The human CRC cell lines SW48 and LIM1215 harbor the wild type (WT) KRAS, NRAS, BRAF, and PIK3CA genes and are considerate an optimal preclinical model of EGFR therapeutic blockade. Since both cell lines have no or ...
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A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury
... FAK signaling, the synergic effect is likely attributed to the potential cross-talk between intracellular signaling mediators associated with FAK and ...
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Genetic and Epigenetic of Medullary Thyroid Cancer
... extracellular signaling molecules [36] ...several signaling pathways, including RAS/extracellular signal-regulated kinase (ERK), phosphatidylinositol 3- kinase (PI3K)/AKT, p38 mitogen-activated protein ...
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Signaling by Non-Canonical Receptor Tyrosine Kinases ERBB3 and RYK
... of intracellular kinase domain, which in turn mediates autophosphorylation and downstream signal ...their intracellular kinase domain, and are thought to be inactive ...non-canonical signaling by ...
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Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling
... cell signaling, we envi- sion oligomolecular interactions among signaling ...given signaling intermediate reacts with a small number of other intermediates to which it binds transiently and ...
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Monocyte NOTCH2 expression predicts IFN-β immunogenicity in multiple sclerosis patients
... The stepwise approach used here was designed to identify DEMs associated with nADA, excluding any marker associated with disease progression (e.g., TIM-3) (52) or response to IFN-β therapy (e.g., CD274, CD123, CD129, ...
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Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes
... tabolism. Intracellular Ca 2+ fluctuation has been sub- stantiated to play a role in the downstream signaling of insulin ...2+ signaling either by treat- ment of calmodulin (CaM) antagonists [8] in ...
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