intracellular trafficking
Distinct Intracellular Trafficking of Hepatitis C Virus in Myeloid and Plasmacytoid Dendritic Cells
... virus to recycling endosomes. Thus, it is very likely that HCV- derived antigens are targeted to recycling endosomal compart- ments to ensure a rapid activation of the HCV-specific CD8 ⫹ T-cell response by utilizing a ...
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Modulation of G Protein-Coupled Receptor Intracellular Trafficking and Signal Transduction
... the intracellular trafficking and recycling of GPCRs by directly interacting with these vesicular cargo proteins, but Rab GTPases also indirectly influence the trafficking of receptors between ...
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Eps15: a multifunctional adaptor protein regulating intracellular trafficking
... to intracellular trafficking. In trafficking, Eps15 acts as an ubiquitin- or Ubl-binding adaptor protein, a function mediated by the two UIMs in the C-terminal part of the ...for trafficking, ...
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Hepatitis B Virus Subviral Envelope Particle Morphogenesis and Intracellular Trafficking
... probably corresponded to the ERGIC compartment. Unfortu- nately, it was technically difficult to confirm this hypothesis by immunogold labeling with an anti-ERGIC antibody. The use of Epon resin and standard EM ...
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Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Growth
... Host posttranslational modifications are heavily targeted by viruses for their own benefit. We and others previously reported that influenza A virus interacts extensively with the host sumoylation system. However, the ...
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The conserved dileucine and tyrosine based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking
... the trafficking of transmembrane and soluble proteins along the secretory ...the intracellular trafficking of envelope glycoproteins should then bring some under- standing as to how they encounter ...
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Intracellular Trafficking Network of Protein Nanocapsules: Endocytosis, Exocytosis and Autophagy
... the intracellular trafficking pathway of nanoparticles in cells have been poorly ...the intracellular trafficking pathway of protein nanocapsules using more than 30 Rab proteins as markers of ...
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Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide
... The trafficking of molecules within cells is partly depend- ent on the mechanism of internalisation, thus, molecules that are ingested via clathrin-dependent endocytosis traf- fic via endosomes into degradative ...
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Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates
... The trafficking studies of these drugs are still ...processing, trafficking mechanism, internalization rate, proteolytic degradation, and binding mechanism of trastuzumab–maytansinoid ...
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Notch1 Augments Intracellular Trafficking of Adeno-Associated Virus Type 2
... mediating intracellular trafficking and nuclear transport of ...after intracellular process- ing of the full-length protein ...the intracellular domain of Notch and allowing trans- location to ...
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Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
... thermore, intracellular trafficking and fate of NPs is a vital process to the success of NPs considering that these car- riers are aimed to target specific sub-cellular compartment and deliver specific ...
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Role of Ubiquitin and SUMO in Intracellular Trafficking
... regulate intracellular trafficking events of existing proteins in ...cells. Trafficking of multiple proteins is controlled reversibly by ubiquitin and/or SUMO directly or indirectly via regulation of ...
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Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups
... desired intracellular compartment (wherein the drug will be liberated), and to remain in the cell for a time period sufficient to allow adequate diagnostic and therapeutic ...and intracellular ...
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The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile
... materials possess when downsized to the nanoscale. One such type of NM are quantum dots (QDs), which are small colloidal semiconductor nanoparticles (NPs) that possess remarkable photophysical properties, includ- ing ...
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Intracellular trafficking of factor VIII to von Willebrand factor storage granules
... The strong interaction between vWf and FVIII is estab- lished clearly in the extracellular environment and has been characterized extensively in plasma (for reviews see references 14 and 21). In fact, if patients with ...
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Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways
... the trafficking of labelled SLTx and its B chain (lacking the toxic A chain) showed a delay in its accumulation at a peri-nuclear location, confirmed to be the Golgi by examination of SLTx B chain metabolically ...
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Intracellular trafficking, and function of receptor tyrosine kinases in mammary gland development
... adaptor complex been im plicated in this process (Folsch et al., 1999; Ohno et al., 1999). ^IB shows 79% homology to the previously identified m edium subunit of A PI (now term ed /ilA). /xlA and (ilB complex w ith API ...
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Intracellular Trafficking Governs the Processing of the Amyloid Precursor Protein and the Secretion of Beta-Amyloid
... lysosomal enzyme function could inhibit both secretase cleavage and nonspecific degradation of βAPP, which would result in paGFP fluorescence accumulation at the lysosome membrane. Therefore, we followed the extinction ...
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Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB
... FIG 3 Evaluation of the role of the autophagosome-lysosome system in A. baumannii intracellular trafficking. (A) The lysosomes in A549 cells were incubated with A. baumannii ATCC 17978 for 2 h, immunostained, and ...
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Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells
... mechanisms underlying cell death are not clear. Imaging molecules of interest in living cells can elucidate how molecules enter cells, traverse intracellular compartments, and interact with sites of activity. ...
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