Intracellular zinc
Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression
... of zinc in the normal function of the prostate and in the development and/or progression of prostate cancer, we investigated the effects of extracellu- lar zinc on zinc accumulation and on mRNA and ...
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Intracellular Zinc Activates KCNQ Channels by Reducing their Dependence on Phosphatidylinositol 4,5-bisphosphate
... other zinc ionophores, DEDTC, DIQ and -tocopherol on KCNQ2 channels. Zinc ionophore activity of -tocopherol is not well documented, but the lack of effect of DEDTC and DIQ is perplexing as in our hands ...
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Intracellular zinc modulates cardiac ryanodine receptor mediated calcium release
... FIGURE 8. Elevated extracellular zinc levels result in an increase in the concentration of intracellular zinc. A, example whole cell recording show- ing the development of an inward current on ...
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Intracellular Zinc Release, 12-Lipoxygenase Activation and MAPK Dependent Neuronal and Oligodendroglial Death
... seven zinc ions, and thus provide strong buffering capacity for intracellular ...which zinc can be re- leased, typically in response to thiol oxi- dization ...all zinc ions ...release ...
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Mild Acidosis Enhances AMPA Receptor-Mediated Intracellular Zinc Mobilization in Cortical Neurons
... Cortical neurons were loaded with the Ca 2+ - (and Zn 2+ -) sensi- tive ratiometric fluorescent probe fura-2 and fluorescence changes evaluated both during a 1 min exposure to 300 µ M k[r] ...
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Depletion of Intracellular Zinc Inhibits the Ubiquitin Ligase Activity of Viral Regulatory Protein ICP0 and Restricts Herpes Simplex Virus 1 Replication in Cell Culture
... tion upon the requirement for ICP0 during infection, we com- pared the PFE of wt HSV-1 and ICP0 null mutant viruses in HF and U2OS cells pretreated with TPEN. Depletion of intracellular Zn 2⫹ inhibited the ...
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Saccharomyces cerevisiae Vacuole in Zinc Storage and Intracellular Zinc Distribution
... of zinc and other elements in both physiological ...of zinc; the same effects were also observed in zrc1 ⌬ cot1 ⌬ mu- tants, in which vacuolar zinc levels are very ...that zinc status affects ...
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Key words
... regulating zinc efflux from cells and its intracellular distribution (mainly with regard to the amount and activity of ZnT-1, but also ZnT-5), a slow process of intracellular zinc accumulation ...
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Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation
... of zinc ion availability in G? carriers after zinc supplementation, suggests a prompt response of cells exposed to increased oxidative stress condition at the baseline, in incorporating zinc which ...
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Relationship between Serum Zinc Level and Microvascular Complications in Patients with Type 2 Diabetes
... pancreas Zinc accumulates under low and high glucose conditions through both Ca channels and other Zinc transporting mechanisms, and the intracellular Zinc inhibits glucagon secretion ...in ...
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The role of metallothionein in zinc homeostasis
... ‘sense’ zinc levels significantly changed the understanding of zinc ...These zinc-sensing proteins are transcription factors that can alter the expression of zinc transporters and storage ...
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Csr1/Zap1 Maintains Zinc Homeostasis and Influences Virulence in Candida dubliniensis but Is Not Coupled to Morphogenesis
... accessible zinc and other metals to inhibit pathogen growth and ...oppose zinc deprivation, pathogenic bacteria and fungi evolved special- ized uptake mechanisms to obtain zinc (8, ...affinity ...
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Leaching Recovery of Zinc, Cobalt and Manganese from Zinc Purification Residue
... 2.2. Experimental Procedure Leaching was carried out in a 0.5-L batch glass reactor. A mechanical mixer agitated the liquor at a speed of 300 rpm and ambient temperature. A water bath was used to control the temperature. ...
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The role of metals in particulate matter-induced toxicity : cardiovascular effects of zinc
... and zinc, vanadium is actually not as toxic to the ...of zinc in the well studied EHC-93 particle as a guide, and found that vanadium did not induce any significant increases in lung injury or inflammatory ...
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Clioquinol-Zinc Chelate: A Candidate Causative Agent of Subacute Myelo-Optic Neuropathy
... clioquinol-zinc chelate, and clioquinol-zinc chelate is a mitochondrial toxin, clioquinol- zinc chelate is a likely cause of SMON.. Materials and Methods.[r] ...
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Zinc Review of Its Present Role in HIV-Infection
... serum zinc levels, 7-9 others have documented declining plasma and serum levels as the disease progresses, and have found lower zinc levels in more advanced stages of the ...blood zinc levels in ...
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Zinc Deficiency Symptoms of Beans
... The effect of added zinc on dry weight, zinc concentration in the foliage and the uptake of zinc by 10 bean varieties grown in the greenhouse.. Variety No Zn Dry weight Zn Zinc concentr[r] ...
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Influence of the Deposition Temperature on the Electrodeposition Mechanism of Zn-Co-Fe Alloy
... The effect of the temperature on the percentages of Co, Fe and Zn in the Zn-Co-Fe alloy from the sulfate bath is shown in Table (1). At low temperatures, the zinc content in the alloy is relatively high, due to ...
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Zinc transporters in Alzheimer’s disease
... by zinc transporters that transport zinc through the membrane to the cyto- plasm or organelles and maintain zinc homeostasis both at the cellular and systemic ...levels. Zinc transporters are ...
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Balancing and Predicting Reactions
... Metallic zinc combines with elemental sulfur to form zinc sulfide... Balance these reactions.[r] ...
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