Intracerebroventricular injection
Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats
... bral cortex of asthmatic rats are significantly higher than those of control rats [12]. All these findings indicate that the changes of these proinflammatory mediators in the CNS may have pathophysiologic effects in ...
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A Survey on Electrocardiographic Parameters in Broiler Chickens Following the Intracerebroventricular Injection of Melatonin
... the intracerebroventricular injection of melatonin are depicted in Table 1 and Figures 1 and ...the injection of melatonin with doses of 200 nmol, the heart rate of these chickens (294 beats/min) ...
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Homocysteine intracerebroventricular injection induces apoptosis in the Substantia Nigra cells and Parkinson like behavior in rat
... The effects of Hcy on the rats’ behavior were studied by an open-field apparatus. All experiments were carried out 5 days after Hcy (intracerebroventricular) injection in rats. The measurement was started 3 ...
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Regulation of Feeding and Mechanisms of Intracerebroventricular Injection of Nesfatin-1 in Obese Rats
... nesfatin-1. Intracerebroventricular injection of the melanocortin receptor agonist MTII reduced food intake by reducing food intake per meal without affecting the frequency of feeding, similar to that ...
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Neurotoxic effects of gadopentetate dimeglumine: behavioral disturbance and morphology after intracerebroventricular injection in rats
... dian lethal dose value of 529 m mol/kg (approx- imately 50 m mol/g brain) was reported by Ad- ams et al (14). These workers also found impaired grip strength, incoordination, and per- sistent hind limb paresis at 150 m ...
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Intracerebroventricular Injection of Lipopolysaccharide Increases Gene Expression of Connexin32 Gap Junction in Rat Hippocampus
... Ketamine (Rotex Medica, Germany), Xylazine (Chanelle, Ireland), LPS (Escherichia coli serotype 026:B6, Sigma, UK), RNX-Plus Reagent, Agarose, Acrylamide (CinnaGene, Iran) Quantitect Reverse Tran- scriptase kit (Qiagen, ...
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Effects of intracerebroventricular injection of vitamin B12 on formalin-induced muscle pain in rats: Role of cyclooxygenase pathway and opioid receptors
... performed using a 5-μL Hamilton syringe over a period of 30 sec with a constant volume of 2.00 μL per rat. After completion of each ICV injection, the injection needle was left in place for further 30 sec ...
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Leukotriene B4, administered via intracerebroventricular injection, attenuates the antigen-induced asthmatic response in sensitized guinea pigs
... After 10% chloral hydrate (3 ml/kg i.p) anesthesia, the animal ’ s head was fixed in a stereotaxic apparatus (SR- 6N, Narishige, Japan). The procedure of i.c.v. injection was as described with minor improvement ...
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Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats
... single injection of ...RFRP-3 injection significantly inhib- ited the release of LH, in an estradiol-dependent manner, in prepubertal female mice ...
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Evaluating the olfactory dysfunction and cognitive deficits induced by intracerebroventricular injection of Amyloid beta (1–42) in female C57BL/6 mice
... i.c.v injection using a stereotaxic apparatus (Steolting, USA) consisting of a 28-gauge stainless-steel needle of ...(i.p.) injection of xylazine (20 mg/kg) and Ketamine (80 mg/kg) cocktail and placed in a ...
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Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice
... icv injection of TLQP-21 exerted a catabolic effect in the Siberian hamster which was asso- ciated with decreased body and WAT weight and was dependent on reduced food intake but not on increased energy ...
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The molecular regulatory effect of intracerebroventricular thymulin on endotoxin mediated NF kB nuclear translocation and activation in vivo
... stereotaxic intracerebroventricular injection of endotoxin (ET/LPS) differentially upregulates the expression of various NF-B subunits, including RelA (p65), the major transactivating member of Rel family, ...
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Autoregulation of Inducible Nitric Oxide Synthase Expression by RNA Interference Provides Neuroprotection in Neonatal Rats
... The staining was performed as we have de- scribed before [16]. Briefly, rats were sacrificed by deep isoflurane anesthesia and transcardially per- fused with 4% paraformaldehyde at 24 h after the brain HI or 4 days ...
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Food intake in free feeding and energy deprived lean rats is mediated by the neuropeptide Y5 receptor
... transients. CGP 71683A was given intraperitoneally (dose range 1–100 mg/kg) to a series of animal models of high hy- pothalamic NPY levels. In lean satiated rats CGP 71683A significantly antagonized the increase in food ...
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Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia
... An important marker in neurodegenerative Alzheimer’s disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory ...
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The role of 5-hydroxytryptamine receptors in central cardiovascular regulation in rats and cats
... microinjection (20 //I over 1 min) of saline. After a 10 min control period a dose of test compound or saline control was given i.c.v. Cumulative dose-response curves were constructed for 5-HT (10, 4 0 , 160 nmol kg-i), ...
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The effect of genistein on intracerebroventricular streptozotocin-induced cognitive deficits in male rat
... ICV injection of STZ is characterized by a progressive deterioration of learn- ing, memory, and cerebral glucose and energy metabo- lism and this may provide an appropriate and relevant experimental model of SAD ...
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MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
... Materials: Streptozotocin was purchased from Sigma–Aldrich, USA. Minocycline was used in the form of marketed preparation (Minoz, Ranbaxy, India). All other chemicals used in the study were of analytical grade. Solutions ...
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Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors
... Treatments were administered at the onset of the dark cycle. ICV injections were administered using a 10 μl gas-tight syringe attached to internal injector cannulas (Plastics One) that extended 1 mm beyond the tip of the ...
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Original Article Knockdown of NF-κB-inducing kinase prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns
... with intracerebroventricular injections of siRNA targeting NIK significantly attenuated acute LPS-sensitized HIbrain injury by inhibiting the non-canonical NF-κB pathway, associated pro-inflammatory cytokine ...
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