intraepithelial lymphocytes
IL 15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease–associated inflammation and lymphomagenesis
... of intraepithelial lymphocytes (IELs) to potent antiapoptotic signals initiated by IL-15, a cytokine overexpressed in the enterocytes of individuals with ...
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Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum
... villi. Intraepithelial lymphocytes expressed low levels of LAR at the tips of the villi with stronger expression extending towards the base of the ...blood lymphocytes expressed less LAR than ...
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Intestinal Intraepithelial Lymphocytes Are Primed for Gamma Interferon and MIP-1β Expression and Display Antiviral Cytotoxic Activity despite Severe CD4+ T-Cell Depletion in Primary Simian Immunodeficiency Virus Infection
... Intraepithelial lymphocytes (IEL) are a critical effector component of the gut-associated lymphoid tissue (GALT) and play an important role in mucosal immunity as well as in the maintenance of the ...
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The Significance of Fas/Fasl Expression in Celiac Disease, Non-Specific Duedonitis and in Duedonum Biopsies Showing Increase in Intraepithelial Lymphocytes
... positive lymphocytes in mucosa was lower in active CD compared to potencially ...blood lymphocytes of CD with untreated and treated patients than the control group ...mucosal lymphocytes on surface ...
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Small intestinal CD8+TCRγδ+NKG2A+ intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac disease
... Intraepithelial lymphocytes (IELs) bearing the gd TCR are more abundant in the small intestinal mucosa of patients with celiac disease (CD) compared with healthy ...
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Direct ex vivo simian immunodeficiency virus (SIV)-specific cytotoxic activity detected from small intestine intraepithelial lymphocytes of SIV-infected macaques at an advanced stage of infection.
... Intestinal intraepithelial lymphocytes (IEL) were isolated, analyzed, and compared to lymphocytes obtained from blood, spleen, and different lymph nodes: IEL were predominantly CD8 1 T ...
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Predominant T-cell receptor Vbeta usage of intraepithelial lymphocytes during the immune response to enteric reovirus infection.
... that intraepithelial lymphocytes (IEL) contain virus-specific cytotoxic T lym- phocytes (CTL) that increase dramatically during the course of virus ...
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Changes in barrier function of a model intestinal epithelium by intraepithelial lymphocytes require new protein synthesis by epithelial cells
... We used transepithelial electrical resistance TER to monitor Gut 1997; 40: 634-640 changes in barrier function over time during Keywords: inflammation, intraepithelial lymphocytes, expos[r] ...
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Fas ligand mediated killing by intestinal intraepithelial lymphocytes Participation in intestinal graft versus host disease
... In vitro studies have demonstrated that intestinal intraepi- thelial lymphocytes (IEL) are constitutively cytotoxic; how- ever, the mechanism and target of their cytotoxicity are un- known. Apoptosis of intestinal ...
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Cytokine secretion induced by superantigens in peripheral blood mononuclear cells, lamina propria lymphocytes, and intraepithelial lymphocytes.
... Superantigens are potent inducers of T-cell proliferation and induce a broad range of cytokines, including tumor necrosis factor (TNF), gamma interferon, and interleukin 2 (IL-2). In the present study, we compared the ...
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Intraepithelial lymphocytes subsets in different forms of celiac disease
... Thus, the enumeration of IELs and the immunophenotyping of IELs subsets (total, cd , and CD3 - IELs) by flow cytometry (FCM), named IEL lymphogram, constitute useful diagnostic tools for[r] ...
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Is There Any Association between Intestinal Lymphoma and Coeliac Like Disease in Prosimians? The Case of the Ring Tailed Lemur (Lemur catta)
... and lymphocytes infiltration in the lamina propria ; impressive vill- ous atrophy and crypt hyperplasia with decreased villous height-to-crypt depth ratio; pronounced increase in the number of ...
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Oral administration of heat killed Tsukamurella inchonensis enhances immune responses and intestinal function in mice
... Intestinal intraepithelial lymphocytes (IELs) are the first in line to come into contact with anti- gens present in the gut (Hershberg and Blumberg 2005; Cheroutre et ...from lymphocytes in the un- ...
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Original Article The Frequency of Lymphocytic and Reflux Esophagitis in Non-Human Primates
... Abstract: We previously reported in humans a novel histologic phenotype of non-gastro-esophageal reflux disease called lymphocytic esophagitis. In this work, the esophagi of 121 non-human primates (103 baboons and 18 ...
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Enterocolitis and colon cancer in interleukin 10 deficient mice are associated with aberrant cytokine production and CD4(+) TH1 like responses
... release intraepithelial lymphocytes (IEL). Lamina propria lymphocytes (LPL) were isolated from the remaining tissue frag- ments by incubation in ...NJ). Lymphocytes were enriched by ...
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Diagnostic challenges in celiac disease
... – intraepithelial lymphocytes; WA – wheat allergy; NGCS – non-celiac gluten sensivity; SNCD – seronegative celiac disease; HLA – human leukocyte antigen; GCD – gluten containing diet; * other causes of ...
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Transmission Electron Microscopic Study of the Microvasculature of the Human Postpartum Fallopian Tube
... Intraepithelial lymphocytes have been demonstrated in the Fallopian tubes (34,63,64). These cells show round to oval nuclei with peripherally condensed chromatin and electron lucent cytoplasm with few ...
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A case of checkpoint inhibitor-induced celiac disease
... She underwent upper endoscopy, which showed bile stasis in the stomach, normal appearing stomach mucosa, and nonbleeding erythematous mucosa in the duodenal bulb (Fig. 1). The second part of the duodenum showed normal ...
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Recovery from chronic rotavirus infection in mice with severe combined immunodeficiency: virus clearance mediated by adoptive transfer of immune CD8+ T lymphocytes.
... Temporary clearance of rotavirus was observed after the transfer of immune CD8+ T cells isolated from the intestinal mucosa intraepithelial lymphocytes [IELs] or the spleens of BALB/c mi[r] ...
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Human papillomavirus type 16 variants in cervical intraepithelial neoplasia and invasive carcinoma in San Luis Potosí City, Mexico
... In this work HPV16 subtypes and variants associated to low-grade intraepithelial lesions (LSIL), high-grade intraepithelial lesions (HSIL) and invasive cervical cancer (ICC) of 38 women [r] ...
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