intraflagellar transport
Getting to the heart of intraflagellar transport using Trypanosoma and Chlamydomonas models: the strength is in their differences
... on intraflagellar transport (IFT), the bi-directional movement of ‘ trains ’ composed of protein complexes found between axoneme microtubules and the flagellum ...
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Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects
... comprises laterality defects and chronic pulmonary infections. High speed video microscopy of cultured epithelial cells from an affected individual showed severely dyskinetic cilia, but no obvious ultra-structural ...
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Evidence of Intraflagellar Transport and Apical Complex Formation in a Free-Living Relative of the Apicomplexa
... Since its first description, Chromera velia has attracted keen interest as the closest free-living relative of parasitic Apicomplexa. The life cycle of this unicellular alga is complex and involves a motile biflagellate ...
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Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis
... Hair follicle morphogenesis requires precisely controlled reciprocal communications, including hedgehog (Hh) signaling. Activation of the Hh signaling pathway relies on the primary cilium. Disrupting ciliogenesis results ...
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Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
... Patched (Ptc), allowing the activation of Smoothened (Smo), another transmembrane protein. The principal target of Hh signaling is the transcription factor Cubitus interruptus (Ci). In the absence of Hh signaling, Ci is ...
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Intraflagellar transport is essential for endochondral bone formation
... requires intraflagellar transport (IFT), and mutations disrupting the IFT process result in loss of cilia and mid-gestation lethality with developmental defects that include polydactyly and abnormal neural ...
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Wang, Qianmin (2017): Structural and Biochemical Characterization of Cell Shaping Proteins: 1. Microtubule Binding Protein p150glued and 2. Intraflagellar Transport Protein 172. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... termed intraflagellar transport (IFT) (Rosenbaum & Witman, ...(anterograde transport) in a kinesin-II motor- dependent manner (Kozminski et al, 1993; 1995) although the molecular basis for train ...
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Intraflagellar transport complex structure and cargo interactions
... Twenty years ago, Kozminsky and colleagues first de- scribed intraflagellar transport (IFT) as a motility in the Chlamydomonas flagellum that is distinct from flagellar beating [1]. IFT trains were observed ...
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The Molecular Identities of the Caenorhabditis elegans Intraflagellar Transport Genes dyf-6, daf-10 and osm-1
... The Caenorhabditis elegans genes dyf-6, daf-10, and osm-1 are among the set of genes that affect chemotaxis and the ability of certain sensory neurons to take up fluorescent dyes from the environment. Some genes in this ...
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DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport
... However, RUVBL1 evidently has other direct or indirect roles in these processes because we unexpectedly observed asymmetric left-handed distribution of RUVBL1 both at the embryonic node [r] ...
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Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track binding elements
... We integrate these data and previous studies into a model for dynein-2 regulation, which enables efficient cycles of IFT (Fig. 7). We propose that following its synthesis and dimerization in the cytosol, dynein-2 ...
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TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport
... Intraflagellar transport (IFT), a highly conserved process required for ciliary growth and signalling, is powered by motors attached to IFT complexes A and ...
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The Small GTPase Rsg1 is important for the cytoplasmic localization and axonemal dynamics of intraflagellar transport proteins
... Cilia are small cellular organelles found across the eukaryotic lineage; they are composed of an axoneme, formed by membrane enclosed microtubule doublets growing from the basal body, an anchoring and nucleat- ing ...
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Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport
... ciliary transport machinery mediated by IFT-B and kinesin-2 motors, the biological functions of retrograde transport medi- ated by IFT-A and dynein motors are poorly understood in vertebrate ...opsin ...
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Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins
... Studies in C. elegans have shown that the homodimeric kine- sin 2, osm-3, plays a major role in ciliogenesis. In this model organism, the amphid channel cilia require kif17 homolog osm-3 for the formation of distal ...
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Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport
... chromosomal clone (BAC) (Fig. 2a). One of four transcribed regions on this BAC encodes ABCC4 (Mrp4), a subfamily ‘ C’ member of the ATP-binding cassette (ABC) superfamily of transport proteins (Fig. 2a, b) 15–17 . ...
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Cilia, Wnt signaling, and the cytoskeleton
... More recently, the primary ciliary membrane has been shown to be rich in various channels and receptors [4,5], suggesting that the cilium may serve as the signal- ing antenna for the cell. In this capacity, cilia might ...
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Intraflagellar Protein 88 Interactome Analysis: A Bioinformatics Approach Highlights Its Role in Testis and Sperm Function
... Intraflagellar transport (IFT) is essential for cilium and flagellar ...IFT88, intraflagellar protein 88, is a core element of IFT complex ...
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Mechanistic insights into Bardet Biedl syndrome, a model ciliopathy
... Nonstandard abbreviations used: ARPKD, autosomal recessive PKD; BBS, BardetBiedl syndrome; CC, connecting cilium; IFT, intraflagellar transport: IS, inner segment; GLI, glioma; JBTS, Jou[r] ...
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Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice
... The mutations that cause Leber congenital amaurosis (LCA) lead to photoreceptor cell death at an early age, causing childhood blindness. To unravel the molecular basis of LCA, we analyzed how mutations in LCA5 affect the ...
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