Intranasal immunization
Intranasal Immunization of Ferrets with Commercial Trivalent Influenza Vaccines Formulated in a Nanoemulsion-Based Adjuvant
... single intranasal immunization, the adjuvanted influenza vaccine elicited elevated serum hemagglutination inhibition (HAI) geometric mean titers (GMTs) ranging from 196 to 905 for the three hemagglutinin ...
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Single Intranasal Immunization with Recombinant Adenovirus-Based Vaccine Induces Protective Immunity against Respiratory Syncytial Virus Infection
... single intranasal immunization with rAd/3xG provided potent protection against RSV challenge which lasted for more than 10 ...single intranasal immunization but not by intramuscular or oral ...
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Protective levels of diphtheria neutralizing antibody induced in healthy volunteers by unilateral priming boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a
... of intranasal immunization have demonstrated the trafficking of primed lymphocytes and prim- ing of distant sites, such as the genital tract and gut, as de- scribed above (4, 11, 21, ...intratonsilar ...
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Highly Pathogenic Avian Influenza H5 Hemagglutinin Fused with the A Subunit of Type IIb Escherichia coli Heat Labile Enterotoxin Elicited Protective Immunity and Neutralization by Intranasal Immunization in Mouse and Chicken Models
... The roles played by adjuvant are most critical for the development of mucosal subunit vaccines for both mucosal and systemic immune induction to elicit more effective protective immunity [26,27]. Cholera toxins or heat ...
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Intranasal Immunization with a Formalin-Inactivated Human Influenza A Virus Whole-Virion Vaccine Alone and Intranasal Immunization with a Split-Virion Vaccine with Mucosal Adjuvants Show Similar Levels of Cross-Protection
... cross-protective intranasal vaccine for clinical ...by intranasal immunization with these vaccines is associated with neutralizing antibody production or cell-mediated immune ...
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H9N2 Influenza Whole Inactivated Virus Combined with Polyethyleneimine Strongly Enhances Mucosal and Systemic Immunity after Intranasal Immunization in Mice
... CTB plus H9N2 WIV induced much higher serum antigen-spe- cific IgG (Fig. 3A), IgG1 (Fig. 3B), and IgG2a (Fig. 3C) antibody titers than H9N2 WIV alone (P ⬍ 0.01). The hemagglutination inhibition (HI) titer in the serum ...
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Induction of Heterosubtypic Immunity to Influenza Virus by Intranasal Immunization
... (H1N1) immunization conferred complete protection against high doses of A/PR8 and A/WSN (H1N1) viruses without any clinical signs of dis- ease but did not provide protection against the heterosubtypic strain ...
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Antibody-Dependent and -Independent Protection following Intranasal Immunization of Mice with Rotavirus Particles
... after intranasal immunization with rotavirus particles, either with or without the attenuated Escherichia coli heat-labile enterotoxin LT(R192G) as an adjuvant, was examined in the adult mouse ...for ...
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Intranasal Immunization against Dental Caries with a Streptococcus mutans-Enriched Fimbrial Preparation
... the immunization protocol used was effective in producing a mucosal and systemic immune response against an ...the immunization regimen with CTB and CT is known to result not only in mucosal responses but ...
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Intranasal Immunization of Mice with CpG DNA Induces Strong Systemic and Mucosal Responses That Are Influenced by Other Mucosal Adjuvants and Antigen Distribution
... Intranasal immunization is desirable for mass vaccination, since it is fast and easy to admin- ister, requires minimal training of personnel, and carries no risk of needle stick injury or cross ...IN ...
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Induction of Mucosal B-Cell Memory by Intranasal Immunization of Mice with Respiratory Syncytial Virus
... protection against challenge. These observed differences might be related to our use of either a low challenge dose or a different viral strain than was used by some other investigators. Interest- ingly, we found that ...
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Intranasal immunization of pigs with porcine reproductive and respiratory syndrome virus like particles plus 2′, 3′ cGAMP VacciGrade™ adjuvant exacerbates viremia after virus challenge
... The adjuvant is known to induce type I interferon to enhance the immunogenicity of vaccine candidates. We examined the IFN-α in the serum before and after virus challenge. IFN-α was detected in all groups prior to virus ...
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Antibody-Independent Protection against Rotavirus Infection of Mice Stimulated by Intranasal Immunization with Chimeric VP4 or VP6 Protein
... mucosal immunization signifi- cantly enhanced immune responses and protection (28, 32, ...that immunization of mice with DNA plasmids containing the gene for VP4, VP6, or VP7 stimulated protection against ...
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Intranasal immunization with a helper dependent adenoviral vector expressing the codon optimized fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in BALB/c mice
... Several studies have shown that HDAd vectors are super- ior to FGAd vectors for vaccine development in terms of their ability to produce immune responses against transgenes and are a robust platform for vaccination ...
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Intranasal Immunization of Lambs with Serine/Threonine Phosphatase 2A against Gastrointestinal Nematodes
... mucosal immunization with the adjuvant and the antigen (PP2Ar) and is expressed against two different species of gastrointestinal ...the intranasal route and the possi- bility of heterologous ...
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Intranasal Immunization of Mice with a Bovine Respiratory Syncytial Virus Vaccine Induces Superior Immunity and Protection Compared to Those by Subcutaneous Delivery or Combinations of Intranasal and Subcutaneous Prime-Boost Strategies
... (PP). Intranasal delivery of the FI-BRSV formulation was superior to subcutaneous delivery in terms of antibody, cell-mediated, and mucosal immune responses, as well as reduction in virus replication after BRSV ...
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Development and Preclinical Evaluation of a Trivalent, Formalin-Inactivated Shigella Whole-Cell Vaccine
... oral immunization with a live-attenuated ...oral immunization with SC602 sug- gests that local production of LPS-specific IgA may play a role in vaccine efficacy in the human ...model. Intranasal ...
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An Intranasally Delivered Toll-Like Receptor 7 Agonist Elicits Robust Systemic and Mucosal Responses to Norwalk Virus-Like Particles
... following intranasal immunization with NV virus-like particles (VLPs) codelivered with or without cholera toxin (CT) or Toll-like re- ceptor (TLR) ...
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Chitosan-Based Intranasal Vaccine against Escherichia coli O157:H7
... To achieve the stability of particles suspension and the inhibition of the particles agglomeration, the zeta potential of particles would be in highly negative or positive values (lower than -30 mV or higher than +30 mV) ...
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Recombinant Parainfluenza Virus 5 Vaccine Encoding the Influenza Virus Hemagglutinin Protects against H5N1 Highly Pathogenic Avian Influenza Virus Infection following Intranasal or Intramuscular Vaccination of BALB/c Mice
... nasal immunization with PIV5 expressing the hemagglutinin from influenza virus was protective against influenza virus chal- lenge ...While intranasal immunization is an appealing approach, PIV5 may ...
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