Intranasal vaccination
Vaginal Memory T Cells Induced by Intranasal Vaccination Are Critical for Protective T Cell Recruitment and Prevention of Genital HSV-2 Disease
... tract. Intranasal immu- nization with a thymidine kinase-deficient (TK ⴚ ) mutant of HSV-2 effectively induces HSV-2-specific gamma interferon (IFN- ␥ )-secreting memory T cell production and protective immunity ...
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Intranasal Vaccination with Chitosan-DNA Nanoparticles Expressing Pneumococcal Surface Antigen A Protects Mice against Nasopharyngeal Colonization by Streptococcus pneumoniae
... Thus, intranasal vaccination may be an alternative approach to current immunization strategies, and effective delivery systems to mucosal organism are ...following intranasal challenge with ATCC 6303 ...
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Intranasal Vaccination with Recombinant Adeno-Associated Virus Type 5 against Human Papillomavirus Type 16 L1
... systemic vaccination does not usually increase the mucosal antibody levels ...of vaccination in humans would be the oral and nasal application ...routes. Intranasal vaccination has emerged as ...
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Ocular Immune Responses in Steers following Intranasal Vaccination with Recombinant Moraxella bovis Cytotoxin Adjuvanted with Polyacrylic Acid
... following intranasal (i.n.) vaccination with a recombinant ...i.n. vaccination of cattle with recombinant ...parenteral vaccination of cattle for immunoprophylaxis against ...
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Intranasal vaccination with extracellular serine proteases of Leishmania amazonensis confers protective immunity to BALB/c mice against infection
... i.n. vaccination with LaSP-Ex and LaSP-Sol were evaluated in ...booster. Vaccination with LaSP-Sol did not sig- nificantly alter the course of infection as compared with controls (Figure ...
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SARS CORONAVIRUS: AN OVERVIEW
... al. Intranasal vaccination of recombinant adeno- associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune ...
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Responses of primary human nasal epithelial cells to EDIII DENV stimulation: the first step to intranasal dengue vaccination
... of vaccination, such as intranasal, oral, topical, vaginal and rectal route, is gaining attention for the vaccine ...global vaccination may be re- quired. It is clear that intranasal ...
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SARS CORONAVIRUS: AN OVERVIEW
... al. Intranasal vaccination of recombinant adeno- associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune ...
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Enhancement of Serum and Mucosal Immune Responses to a Haemophilus influenzae Type B Vaccine by Intranasal Delivery
... (i.n.) vaccination is potentially the most direct method for conveying upper respiratory and mucosal immunity to respiratory ...i.n. vaccination in a mouse immune-re- sponse model with a commonly used ...
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AuNP-M2e + sCpG vaccination of juvenile mice generates lifelong protective immunity to influenza A virus infection
... sCpG vaccination seems particularly promising because it is easy and inexpensive to produce, has a short manufacturing time, is egg-free, and can be lyophilized so that it is stable long term at room temperature ...
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Dose Response of Attenuated Bordetella pertussis BPZE1-Induced Protection in Mice
... Despite the availability of efficacious vaccines, the incidence of whooping cough is still high in many countries and is even increasing in countries with high vaccine coverage. Most severe and life-threatening pertussis ...
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Case of Advanced Recurrent Glioblastoma Successfully Treated with Monoterpene Perillyl Alcohol by Intranasal Administration
... the intranasal route provides a practical, noninvasive method for transportation of lipophilic and apolar drugs straight to the central nervous system ...by intranasal route in patients with recurrent GBM ...
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Randomised, crossover clinical trial, in healthy volunteers, to compare the systemic availability of two topical intranasal budesonide formulations
... The systemic bioavailability of nasal corticosteroids is greatly influenced both by the vehicle and by the device characteristics (determining the particle size and the per- centage of deposition) [8,9], and therefore, a ...
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The analgesic effect of combined treatment with intranasal S-ketamine and intranasal midazolam compared with morphine patient-controlled analgesia in spinal surgery patients: a pilot study
... S-ketamine intranasal spray in the ...S-ketamine intranasal spray could be considered as an alternative, completely noninvasive analgesic procedure in a postoperative outpatient ...
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A Comparative Evaluation of Intranasal Dexmedetomidine and Intranasal Midazolam for Premedication in Children
... The intranasal route was used in our study as it is non- invasive, unlike intravenous and intramuscular routes, and Produces a more rapid onset of action than the oral ...
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NANOCARRIER FOR INTRANASAL ADMINISTRATION
... structure. Intranasal administration is a promising approach for rapid- onset and delivery of medication to the CNS bypassing the ...BBB. Intranasal drug delivery is one of the major delivery options for ...
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Intranasal administration of poly gamma glutamate induced antiviral activity and protective immune responses against H1N1 influenza A virus infection
... Influenza A virus is an important human pathogen that continues to affect global health and cause pan- demics sporadically, including the 2009 H1N1 influ- enza outbreak. Vaccination is the most economic and ...
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Aerosolized adenovirus-vectored vaccine as an alternative vaccine delivery method
... that intranasal delivery or vaccination in the respiratory tract with recombinant viral vectors can enhance immunogenicity and protection against respiratory diseases such as influenza and tuberculosis, and ...
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Intranasal administration of cationic liposomes enhanced granulocyte–macrophage colony stimulating factor expression and this expression is dispensable for mucosal adjuvant activity
... Furthermore, intranasal co-administration of antigens with a GM-CSF-expressing plasmid has been shown to increase OVA-specific mucosal IgA and serum IgG titers, suggesting that GM-CSF plays an essential role in ...
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Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study
... parameters as shown in Table 1. DTP (%) represents the percentage of drug directly transported to the brain via the olfactory pathway and the trigeminal neural pathway. The TQ-NP1 showed significantly high (P . 0.001) ...
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