intratracheal instillation
Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats
... an intratracheal instillation of straight MWCNTs in rats using a different test system — the Pig-a gene mutation assay — that can reflect the genotoxicity occurring in the bone ...upon intratracheal ...
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Intratracheal instillation of ethyl pyruvate nanoparticles prevents the development of shunt-flow-induced pulmonary arterial hypertension in a rat model
... received instillation of FITC, FITC-NP, and NPs ...single intratracheal instillation of FITC-NPs into rats that had undergone shunt flow, in order to assess FITC ...
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Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation
... material as pristine as possible for better comparison to the uncoated, pristine material used for inhalation; and, 5) in a pilot study, we determined that pretreatments with coating or sonication can modify the ...
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Biodistribution and toxicity of radio-labeled few layer graphene in mice after intratracheal instillation
... Twenty-five mice were randomly divided into five groups of five mice each. Mice were anesthetized with 10 % chloral hydrate (280 to 350 mg/kg body weight). Fifty μL of 14 C labeled FLG suspension (0.1 mg/mL, 1.3 × 10 5 ...
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Airport emission particles: exposure characterization and toxicity following intratracheal instillation in mice
... [70]. Intratracheal instillation proced- ure: A syringe was prepared with correct instillation dose in 50 μl vehicle located at the top and 200 μl air lo- cated after the instillation volume, ...
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Intratracheal instillation of keratinocyte growth factor decreases hyperoxia induced mortality in rats
... animals. Intratracheal instillation of 5 mg/kg rhKGF stimulated a marked, time-dependent increase in the alveolar type II cell specific labeling index to a maximum level of 33 +/- 3% 48 h after rhKGF ...
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Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats
... that intratracheal instillation of CeO 2 nanoparticles (Figure 1) results in increased liver ceria levels (Figure 2), and that these changes in liver ceria are associated with evidence of liver pathology ...
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Early Intratracheal Instillation of Budesonide Using Surfactant as a Vehicle to Prevent Chronic Lung Disease in Preterm Infants: A Pilot Study
... PATIENTS AND METHODS. We conducted a prospective, randomized blind trial in 116 very low birth weight infants ( ⬍ 1500 g) who had severe radiographic respiratory distress syndrome and required mechanical ventilation with ...
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Macrophages participate in local and systemic inflammation induced by amorphous silica nanoparticles through intratracheal instillation
... Female Balb/c mice (8 weeks old, 20–22 g in body weight) were purchased from Weitong-Lihua Experimental Animal Center (Beijing, People’s Republic of China) and raised in specific pathogen free (SPF)-class animal room ...
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Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area
... Background: The production and use of nanoparticles is growing rapidly due to the unique physical and chemical properties associated with their nano size and large surface area. Since nanoparticles have unique ...
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Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies
... cheal instillation and inhalation exposure studies in order to examine the involvement of alveolar epithelial cell injury in lung injury by nano ...the intratracheal instillation of full- erenes and ...
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The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice
... into the ambient air, resulting in exposure to humans by inhalation. Recent studies have reported the development of lung toxicity after pulmonary exposure to CeO 2 NPs. However, little is known about the possible ...
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Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation
... however, that they used rats, not mice, in their study. Also they exposed animals via inhalation, not instillation. We found that gold could be traced in macrophages in the lungs in all 6 mice 1 hour after they ...
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Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin
... Based on lung proteome analysis, ANXV, which is a cal- cium- and phospholipid-binding protein, had the second greatest increase (>27-fold change at 24 hours) and the Graphs of protein[r] ...
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Original Article Mannose prevents acute lung injury through mannose receptor pathway and contributes to regulate PPARγ and TGF-β1 level
... In this study, we used a mouse endotoxemic model induced by intratracheal instillation of LPS, which may mimic sepsis-associated ALI in humans, and the RAW264.7 murine macro- phage cell line, to study the ...
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Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition
... of intratracheal instillation of the respirable frac- tion of six different types of composite epoxy dust (5 mg/200 g) in rats followed by an evaluation of end- points 1 month after ...
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Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response
... received intratracheal instillation of CpG-ODN (10 μM); 6 h or 1, 2, 7, or 14 days later, BAL fluid was obtained and used to perform a differential cell ...CpG-ODN instillation induced a significant ...
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ASSESSMENT OF EXTRAPULMONARY TOXICITY INDUCED BY CARBON NANOMATERIALS FOLLOWING INTRA TRACHEAL INSTILLATION IN RATS
... Some of the reported the pulmonary toxicities induced by different CNMs such as single wall carbon nanotubes, MWCNTs and CNFs following intratracheal instillation in rats after 1 day, 1 week, 1 month, and 3 ...
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Effects of nitric oxide synthase inhibitor ω-Nitro-L-Arginine Methyl Ester, on silica-induced inflammatory reaction and apoptosis
... [20], intratracheal instillation of silica (100 mg/kg BW)caused overproduction of both superoxide and nitric oxide 24 hours ...after intratracheal instillation of silica or saline and intra- ...
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Inhibition of poly (adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats
... The intratracheal instillation of LPS induced metabolic acidosis and hypotension, decreased arterial oxygenation, and increased the lung wet/dry ratio and mRNA expres- sions of TNF-α, IL-1β and IL-6 in the ...
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