Intratumor heterogeneity
From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity
... GB intratumor heterogeneity [24, 31], our results confirmed that the core is an area of high proliferation and inflammation and that tumor margins are infiltrated brain areas which transcriptome is ...
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Cancer-associated fibroblasts enhance tumor 18F-FDG uptake and contribute to the intratumor heterogeneity of PET-CT
... 2016. Cancer-associated fibroblast (CAF) densities were calculated with the inForm Advanced image analysis software and were comparatively analyzed between patients with high and low maximum SUV (SUVmax-high and ...
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In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics
... tumor heterogeneity is complex with one aspect being the variable content of cancer cells with acquired somatic mutations and genetically normal stromal and inflammatory ...
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Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
... of intratumor heterogeneity and the clonality of driver mutations on prognosis and response to precision medicine has not been studied ...of intratumor heterogeneity and the (sub)clonality of ...
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Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.
... of intratumor heterogeneity at the copy number ...of intratumor heterogeneity based on PDGFRA aberrations in patient sp49; whereas fragments T and T2 show no alterations, focal gain and ...
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New insights from the widening homogeneity perspective to target intratumor heterogeneity
... The second strategy is to block cellular plasticity by preventing the transition between cellular states, which may increase therapeutic efficacy. This strategy includes inhibitors of c-Met [35] and TGF-β [36]. Moreover, ...
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The Impact of Optimal Respiratory Gating and Image Noise on Evaluation of Intratumor Heterogeneity on 18F-FDG PET Imaging of Lung Cancer.
... Although we have studied the influence of important sources of measurement variability on quantification of intra-tumor heterogeneity, several other important sources that can contribute to measurement variability ...
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Therapeutic implications of intratumor heterogeneity for TP53 mutational status in Burkitt lymphoma
... chemoresistance in a 43-year old woman affected by stage IVB Burkitt lymphoma with bulky abdominal masses and peritoneal effusion. The patient, despite a transient initial response to chemotherapy with reduction of the ...
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Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
... Figure 1. Tumor-metagenomes and subclonal genomes in 12 tumor types from TCGA (a) Prevalence of non-silent somatic SNVs per tumor. Percentage of tumor-metagenome affected by (b) single copy gains/amplifications and (c) ...
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Quantitative assessment of the spatial heterogeneity of tumor infiltrating lymphocytes in breast cancer
... high intratumor heterogeneity may yield results that are not representative of the entire ...mor heterogeneity of TIL ...measured intratumor heterogeneity at three levels: ...
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Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity
... Finally, these data support the concept of multiple cancer biopsy protocols to ensure that functional intratumor heterogeneity is well represented in a PDO-driven platform. For example, as shown in Figure ...
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REVIEW The Impact of Tumor Eco-Evolution in Tumor Sampling
... establishing a personalized therapy. Intratumor heterogeneity (ITH) detection relies on the correctness of tumor sampling and this is part of the pathologist’s daily work. International protocols for tumor ...
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Comparison of Two EpCAM-Based Methods for CTC Detection and Molecular Characterization in Advanced Colorectal Cancer
... dynamic heterogeneity of cancer and may eventually serve to take therapeutic ...the intratumor heterogeneity (ITH) explains the tumor sampling bias that can occur when performing solid biopsies, as ...
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The degree of intratumor mutational heterogeneity varies by primary tumor sub-site
... genetic heterogeneity of tumors, as well as the evolution of further genetic alterations is of critical importance to the development of therapies aimed at eradicating all clones to successfully treat ...of ...
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Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management
... including heterogeneity in epidemic models and estimating vaccine effects across disease ...Frequently, heterogeneity in suscep- tibility among hosts is unknown or is incorporated into model structure ...
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BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics
... good biocompatibility, and a lower r 2 :r 1 ratio (1.06). Strong absorption in the visible NIR region of GA-Fe@BSA NPs gave them the potential application as an MRI diagnosis and photothermal therapy tool. Moreover, ...
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Celebrating the Heterogeneity of Enterprise Education: Myths and Realities
... When asked to nominate the most significant influence upon their approach to teaching enterprise education, the reported information was revealing. In all, 97 educators nominated 78 sources of influence (including their ...
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Converting Neuroimaging Big Data to information: Statistical Frameworks for interpretation of Image Driven Biomarkers and Image Driven Disease Subtyping
... this heterogeneity may allow us to build better classifiers for identifying such diseases from individual brain ...this heterogeneity are ...disease heterogeneity using population neuroimaging ...
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rs965513 polymorphism as a common risk marker is associated with papillary thyroid cancer
... Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. With the rapid development of genome-wide association studies (GWAS), many genome variants associated with susceptibility to PTC have been ...
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Procalcitonin guided antibiotic therapy in critically ill adults: a meta analysis
... using the strategy of increasing the antimicrobial spectrum of antibiotics as an intervention in ICU patients may not be appropriate. What deserved to be noticed was that length of hospitalization showed de- crease in ...
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