Intravenous artesunate
Post treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia
... Parenteral artesunate has been shown to be a superior treatment option compared to parenteral quinine in adults and children with severe ...with artesunate have been reported in European travellers with ...
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Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults
... of intravenous artesunate in Ugandan adults with severe ...of artesunate and dihydroartemisinin measured by solid-phase extraction and liquid chromatography-tandem mass ...maximal artesunate ...
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Assessment of parasite clearance following treatment of severe malaria with intravenous artesunate in Ugandan children enrolled in a randomized controlled clinical trial
... Methods: Parasite clearance data obtained from a clinical trial whose objective was to evaluate the 42‑day para‑ sitological treatment outcomes and safety following treatment of severe malaria with intravenous ...
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Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin Piperaquine
... Background: Treatment for severe malaria must be prompt with effective parenteral antimalarial drugs for at least 24 h to achieve fast parasite clearance, and when the patient can tolerate oral therapy, treatment should ...
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Intravenous Artesunate for Transfusion-Transmitted Plasmodium vivax Malaria in a Preterm Neonate
... travenous artesunate was started at a dose of ...mg artesunate dis- solved in 5 mL normal saline and 5 mL sodium bicarbonate to prepare 6 mg/mL solution), followed by ...as intravenous infusion) ...
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Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study
... (IV) artesunate (AS) has been shown to com- pletely inhibit parasite growth in infected human patients within two to four hours after dosing, and its active me- tabolite, dihydroartemisinin (DHA), is the only ...
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Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium
... All extracted data were entered into a Microsoft Access ® database and reviewed for inconsistencies. Routine statisti- cal analyses were carried out using IBM SPSS Statistics 18 (IBM Inc, Chicago, IL). Descriptive ...
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Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial
... by intravenous QNN compared to intra- venous ...use intravenous AS in preference to intravenous QNN for initial treatment for severe malaria and calls for improved availability and accessibility to ...
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Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria
... Oral MB has already been investigated as a treatment for uncomplicated malaria. Since the bio-availability of MB is approximately 70% [10], the MB regimens of 10– 12 mg/kg twice a day for three days that were used in ...
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Towards optimal design of anti malarial pharmacokinetic studies
... These various problems could be overcome by designing population PK studies using both information regarding the practical constraints of sampling and optimal design methods[15]. Optimal design methods provide designs ...
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Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: Phase 1b study
... of intravenous AS is the absence of a prod- uct that is manufactured under good manufacturing practices ...of intravenous artesunate studied in 40 healthy volunteers ...
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Rapid titrimetric and spectrophotometric methods for the determination of artesunate in bulk and tablet formulations
... malaria. Artesunate being the most widely distributed and used makes it a major candidate for adulteration and counterfeiting just like any other very successful ...counterfeit artesunate in South East Asia ...
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<p>Role of GRP78 inhibiting artesunate-induced ferroptosis in <em>KRAS</em> mutant pancreatic cancer cells</p>
... Figure 1 Artesunate induced ferroptosis in KRAS mutant pancreatic cancer cells in vitro. (A) AsPC-1 and PaTU8988 were treated with DMSO (control), ART (artesunate, 20 µM), ART (20 µM) + Fer-1 ...
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Artemisinin based combinations versus amodiaquine plus sulphadoxine pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali
... AS+AQ, artesunate + amodiaquine; AS+SP, artesunate + sulphadoxine-pyrimethamine; AQ+SP, amodiaquine + sulphadoxine-pyrimethamine ETF, early treatment failure; LCF, late clinical failure;[r] ...
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Evaluation of Artesunate and Praziquantel Combination Ther-apy in Murine Schistosomiasis mansoni
... combined artesunate-PZQ treated group 3w pi showed almost normal hepatic architecture with complete absence of granu- lomas this result was also recorded by several studies on artemether (13, ...25). ...
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HPTLC determination of artesunate as bulk drug and in pharmaceutical formulations
... speed was employed. The mobile phase consisted of toluene: ethyl acetate: acetic acid (2:8:0.2). The chromatogram was developed in a Camag twin trough glass chamber using a linear ascending technique. The chamber ...
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The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data
... Artesunate-amodiaquine (AS-AQ) is currently the first line treatment in 24 countries, mainly in sub-Saharan Africa, and the second most widely used ACT globally after artemether-lumefantrine [2]. AS-AQ is ...
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Effect of artesunate mefloquine fixed dose combination in malaria transmission in amazon basin communities
... Fixed-Dose Artesunate-Based Combination Therapies (FACT) Consortium, created by the Drugs for Neglected Diseases initiative (DNDi) and the Special Programme for Research and Training in Tropical Diseases (TDR), ...
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Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data
... AS: Artesunate; AS- AQ: Artesunate-amodiaquine; ASAQ-coblistered NFDC: Non-fixed dose combination in a co-blister formulation; ASAQ-FDC: Fixed dose combination; ASAQ-loose NFDC: Non-fixed dose combination ...
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Artemisinin-based combination therapy for treating uncomplicated malaria (Review)
... Comparison 1 Dihydroartemisinin-piperaquine vs Artesunate plus mefloquine, Outcome 10 Serious adverse events (including deaths). Comparison 1 Dihydroartemisinin-piperaquine vs Artesunate[r] ...
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