Intrinsic Apoptosis
Contribution of enhanced intrinsic apoptosis to renal ischemia reperfusion injury in the absence of RIPK3 and Caspase-8 dependent regulated cell death
... target apoptosis, it may be possible to tailor strategies that affect intrinsic apoptosis more than extrinsic ...of intrinsic apoptosis inhibition might be up-regulation of ferroptosis, ...
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Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells
... detected in other gene transcripts (Figure 5G). However, after 48-hour SiNP treatment, a shift toward a proapoptotic transcriptional profile was observed, with significant up- regulation of BAX, PUMA, and NOXA, ...
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Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution
... induced intrinsic apoptosis. The apoptosis rate was significantly decreased in SW480 cells infected with lentivirus carrying short hairpin RNA (shRNA) of PGAM5L, but not of PGAM5S (Figure 3A, ...
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NS 398 induces caspase dependent, mitochondria mediated intrinsic apoptosis of hepatoma cells
... tively, and 0.96 ± 0.15, 1.19 ± 0.18, and 1.30 ± 0.20 (P < 0.05) at 24, 48, and 72 h in case of 200 μM NS-398, re- spectively (Figure 4(b)). In company with this observa- tion, a cytosolic accumulation of cytochrome ...
8
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling
... the apoptosis inducing capacity of single agents and drug combinations should be studied in detail due to the major impact on extrinsic and intrinsic apoptosis sensitivity detected ...
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<p>Evodiamine Selectively Inhibits Multiple Myeloma Cell Growth by Triggering Activation of Intrinsic Apoptosis Pathway</p>
... induced apoptosis is associated with intrinsic apoptosis pathway, we treated U266 and RPMI8226 cells with different concentrations of Evo for 24 h and measured the caspase-3, − 8 and − 9 ...cell ...
9
A polymethoxyflavone from Laggera pterodonta induces apoptosis in imatinib-resistant K562R cells via activation of the intrinsic apoptosis pathway
... inducing apoptosis in K562R cells. There are two main apoptosis pathways: the extrinsic death receptor pathway and the intrinsic mitochondrial pathway ...induce apoptosis via the mitochondrial ...
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
... Mitotic catastrophe is a regulated oncosuppressive mechanism that impedes the proliferation and/or survival of cells that are unable to complete mitosis owing to extensive DNA damage, problems with the mitotic machinery, ...
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Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
... of intrinsic apoptosis as their expression, localization, and binding ...promote apoptosis in colon cancer ...using apoptosis antibody microarray data ...
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Inhibitive effects of 15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis
... induced apoptosis in HCC cell ...the apoptosis assays (Figure ...demonstrated apoptosis-related protein expression, including cytochrome C, Bax, caspase 3, caspase 9, caspase 8, and PARP1, in all HCC ...
9
RMP/URI inhibits both intrinsic and extrinsic apoptosis through different signaling pathways
... evading apoptosis of tumor cells may result in chemotherapy ...drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and ...
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Mechanism of metastasis suppression by luteolin in breast cancer
... Notes: Illustration abridging the involvement of luteolin (green) in purposed apoptotic pathways. Luteolin sensitized the DR, activated caspase 8, and induced caspase 3-mediated apoptosis. Decreased FAS activity ...
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The intrinsic or the extrinsic pathways of apoptosis in the epidermis after cladribine application?
... ing apoptosis after cladribine ...of apoptosis in the rats’ epidermis, induced by cladribine given in the scheme used in the treatment of MS in humans, in- volves caspase 9 ...the intrinsic ...
8
Short telomere syndromes cause a primary T cell immunodeficiency
... Here, we report a primary and potentially fatal T cell immu- nodeficiency in young patients with short telomere syndromes, its overall prevalence, and its association with recurrent patterns of opportunistic infections. ...
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So Cheong Ryong Tang induces apoptosis through activation of the intrinsic and extrinsic apoptosis pathways, and inhibition of the PI3K/Akt signaling pathway in non small cell lung cancer A549 cells
... cell apoptosis in vitro ...the intrinsic apoptosis ...extrinsic apoptosis pathway by increasing both TRAIL and FasL, resulting in the activation of caspase-8 and Bid ...the intrinsic ...
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Activation of the intrinsic and extrinsic pathways in high pressure-induced apoptosis of murine erythroleukemia cells
... One pathway of caspase-3 activation is associated with the release of cytochrome c from the mitochondria [4, 7]. The released cytochrome c binds to Apaf-1 (apoptotic protease activating factor-1). This oligomeric ...
9
TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways
... cyte apoptosis with respect to cardiac remodel- ing, the results of this study provide several new insights into the mechanisms that contribute to programmed cardiomyocyte cell death in ...of apoptosis in ...
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<em>Phyllostachys edulis</em> extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation
... Conclusion: Our results indicated that PEE suppressed the growth of 143B and MG-63 cells but moderately affected MRC-5 cells. PEE-induced apoptosis may attribute to AMPK activation and the following activation of ...
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Hyperammonia induces specific liver injury through an intrinsic Ca2+-independent apoptosis pathway
... primary hepatocytes (24.7 ± 1.71) were significantly greater than those in the control group (3.1 ± 0.71). while The hyperammonia groups of HepG2.2.15 (0 mM 3.73 ± 0.47; 20 mM: 6.60 ± 0.36) and HepG2 cells (0 Mm: 4.07 ± ...
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<em>Kelussia odoratissima</em> Mozaff. activates intrinsic pathway of apoptosis in breast cancer cells associated with S phase cell cycle arrest via involvement of p21/p27 in vitro and in vivo
... Overall, our study results revealed that K. odoratissima has potential anticancer effects against breast cancer cells in vitro and in vivo. Our data proposed that KME can initiate antiproliferative and apoptotic effects ...
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