Intrinsic apoptotic pathway
Original Article Exogenous SARI interacts with c-JUN and triggers the intrinsic apoptotic pathway in MG-63 osteosarcoma cells
... the intrinsic apoptotic ...the intrinsic apoptotic proteins by repression of Bcl-2, up-regulation of Bax, as well as activa- tion of the caspase cascades, hinting that SARI re-expression in ...
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Original Article Exogenous WWOX enhances apoptosis and weakens metastasis in CNE2 nasopharyngeal carcinoma cells through the intrinsic apoptotic pathway
... the intrinsic apop- totic pathways [7, 13, 14, ...signaling pathway. Bcl-2 is one of the criti- cal regulators of the apoptotic process and regulates apoptosis by controlling the mito- chondrial ...
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Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line
... spectrophotometry revealed dissipation of mitochondrial membrane potential and an increase in superoxide levels in the ESE-16-treated cells when compared to the relevant controls. Both initiator caspase 9 and effector ...
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Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway
... Results: Both TP and andrographolide showed an antiproliferative effect in a dose-dependent manner when applied on U937 cells separately; however, pretreating the cells with androgra- pholide before applying TP exhibited ...
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miR-342 overexpression results in a synthetic lethal phenotype in BRCA1 -mutant HCC1937 breast cancer cells
... encodes the IAP family member Apollon/BRUCE [16, 17]. We previously showed that Apollon/BRUCE silencing in BCa cells promoted apoptosis through the activation of caspase-3 and -9 in a p53 wild-type background [21]. In ...
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Reovirus Infection or Ectopic Expression of Outer Capsid Protein μ1 Induces Apoptosis Independently of the Cellular Proapoptotic Proteins Bax and Bak
... the intrinsic apoptotic ...the intrinsic apoptotic pathway was activated by 1 expression, we assessed the release of cytochrome c ...
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The Proapoptotic Bcl-2 Protein Bax Plays an Important Role in the Pathogenesis of Reovirus Encephalitis
... receptor pathway (4, 13), the role of the intrinsic pathway in reovirus-induced apoptosis in vivo has not been well ...extrinsic pathway initiator caspase 8 and links activation of the ...
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The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells
... apoptotic gene with highest expression in this cell line and the mRNA expression of Mcl-1 was reduced in a dose- dependent manner after PRL-3 inhibition (Figure 5A). The INA-6-WT cells had almost no Bcl-2 ...
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Manumycin induces apoptosis in prostate cancer cells
... In summary, in these prostate cancer cell lines, manumycin activated the intrinsic apoptotic pathway, with involvement of the Bcl-2 family as a signaling mediator. Our findings may help to elucidate ...
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Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
... independent of p53. This effect of Artonin E was in addition to its significant upregulation of pro-apoptotic proteins with the downregulation of inhibitors of apoptosis. Interestingly, Artonin E inhibited livin, ...
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Breast cancer: Small molecules targeting apoptosis, a prospective approach to safe scientific success
... mitochondrial pathway of apoptosis is the major mechanism of physiological cell death in ...this pathway, proapoptotic members of the Bcl-2 family (contain only a BH3 domain) cause mitochondrial outer ...
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“The Patterns of Apoptosis – A Review” by M.A.Fazeelath Banu, India.
... two apoptotic pathways, namely the perturbation of mitochondria (intrinsic pathway) or the triggering of cell surface death receptors (the extrinsic pathway) 78, 79 ...the intrinsic ...
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BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway
... Carotenoids and their metabolites are widespread and exert key biological functions in living organisms. In vertebrates, the carotenoid oxygenase BCMO1 converts carotenoids such as , -carotene to retinoids, which are ...
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Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
... has been associated with mitochondrial dysfunction, leakage of cytochrome c, and downstream apoptotic activation [22, 32, 37–39]. Emodin’s ability to modulate both anti- and pro-apoptotic Bcl-2 family ...
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Effects of rhodiola crenulata on mice hearts under severe sleep apnea
... mitochondria-dependent apoptotic pathways are the two major pathways triggering cardiac apoptosis ...receptor-dependent apoptotic (Type I) pathway is a key pathway triggering cardiac apoptosis ...
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Plasmacytoid dendritic cells promote HIV 1–induced group 3 innate lymphoid cell depletion
... The role of ILC3s, espe- cially tissue-resident ILC3s, during HIV-1 disease pro- gression is poorly defined due to a lack of relevant models and limited access to the tissues in humans. Humanized mouse mod- els have been ...
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Original Article MPTP related mitochondrial pathway in oroxylin A induced-apoptosis in HepG2 cancer cells
... Abstract: Oroxylin A is a flavonoid extracted from the root of Scutellaria baicalensis Georgi. Our previous work dem- onstrated that oroxylin A induced cell apoptosis via the mitochondrial pathway in cancer cells. ...
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Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway
... the apoptotic pathway has been considered an intriguing strategy for cancer ...apoptosis pathway-related targets have been extensively studied and defined to be ...the apoptotic signaling ...
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Apoptotic cells trigger a membrane initiated pathway to increase ABCA1
... of apoptotic cells daily and, during this process, take up large quantities of ...the apoptotic cell clearance process is linked to macrophage ABCA1 expression is not ...signaling pathway that drives ...
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Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
... mechanotransduction pathway involving Rho/Rho kinase (Rho/ROCK), actin cytoskeletal remod- eling, and a mechanosensitive transcription factor, megakaryoblastic leukemia 1 (MKL1), that coordinately regulate ...
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